Faktor risiko yang mempengaruhi length of stay pasien kanker solid dengan febrile neutropenia pasca kemoterapi neoadjuvant/terapeutik di Ruang Isolasi RSUP Sanglah, Bali

Abstract

Background: Febrile neutropenia is a common complication in patient undergoing chemotherapy. Length Of Stay (LOS) is an important marker for disease severity and use of medical resources in febrile neutropenia. This study was done to find the risk factor affecting length of stay in solid cancer patients with febrile neutropenia post neoadjuvant/therapeutic chemotherapy. Method: This is a case control study without matching. Age ≥ 60 years, (Absolute Neutrofil Count) ANC level < 1,5 μL , comorbid, Hb level <10 gr/dl, and albumin < 3 gr/dl, were related to LOS (≤ 5 days and > 5 days). Univariate (chi square) and multivariate Latar Belakang: Febrile neutropenia merupakan komplikasi yang cukup sering didapat pada pasien yang sedang menjalani kemoterapi. Length Of Stay (LOS) merupakan penanda penting untuk derajat keparahan penyakit dan pengeluaran biaya kesehatan pada febrile neutropenia. Penelitian ini dilakukan untuk mencari faktor risiko yang dapat mempengaruhi lama hari perawatan pada pasien kanker solid dengan febrile neutropenia pasca kemoterapi neoadjuvant/terapeutik. Metode: Penelitian ini merupakan studi kasus kontrol tanpa matching. Usia ≥ 60 tahun, Nilai Absolute Neutrofil Count (ANC) < 1,5 μL , komorbid, Hb<10 gr/dl, dan albumin < 3 gr/dl (logistic regression) were used to analyse the statistic. Results: Forty six patients met inclusion-exclusion criteria were included in this study. ANC level in all patients were < 1,5 μL (100%). Hb level <10 gr/dl is statistically significant (P<0.05), whereas age ≥ 60 years, and comorbid, albumin level < 3 gr/dl were not is statistically significant (P>0.05). Conclusion: Hb level < 10 gr/dl is the risk factor for LOS > 5 days in solid cancer patients with febrile neutropenia post neoadjuvant/ therapeutic chemotherapy. dihubungkan dengan lamanya LOS (LOS ≤ 5 hari dan > 5 hari). Analisis penelitian menggunakan analisis univariat (chi square) dan multivariat (regresi logistik) dengan SPSS versi 16. Hasil: Sejumlah 46 pasien memenuhi kriteria inklusi-eksklusi pada studi ini. Nilai ANC pada seluruh sampel penelitian <1,5 μL (100%). Kadar Hb<10 gr/dl bermakna signifikan secara statistik (P<0,05), sedangkan faktor usia ≥ 60 tahun, komorbid, dan albumin < 3 gr/ dl tidak berbeda bermakna (P>0,05). Kesimpulan: Kadar Hb < 10 gr/dl merupakan faktor risiko lamanya LOS > 5 hari pada pasien kanker solid dengan febrile neutropenia paska kemoterapi neoadjuvant/terapeutik.

Psychological and sexual problems of cancer survivors

“…For example, patients with breast cancer who receive an initial treatment with receptor therapy followed by maintenance therapy have a recurrence rate of 5% to 9% (31). For cancer patients, the World Health Organization has created evaluation criteria for classifying clinical recurrence and remission in solid tumors called the Response Evaluation Criteria in Solid Tumors, which consists of several definitions including complete response, partial remission, progressive disease, and stable disease (32). The definitions are used to assess the extent of the response obtained by cancer patients who have received different modalities of treatment such as chemotherapy, radiation, and surgery.…”