Fall in Human Herpesvirus 6 Seropositivity With Age

Brown, Nathaniel; Sumaya, Ciro V.; Liu, Chun Ren; Ench, Yasmin; Kovács, Andrea; Coronesi, Maria; Kaplan, Mark H.

doi:10.1016/s0140-6736(88)92864-4

Cited by 111 publications

(45 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4 -6 HHV-6-specific IgG can be detected in almost all newborns, but the prevalence declines to less than 10% by 4 to 5 months of age, presumably as maternal antibody wanes. 4 The seroprevalence increases to 65% by 1 year of age 6 and to greater than 90% by 13 to 36 months of age. 4,6,7 Accumulating clinical and laboratory evidence suggests that HHV-6, like all other herpesviruses, may have neurotropic properties.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Case-Control Study of Primary Human Herpesvirus 6 Infection in Children With Febrile Seizures

Hukin

Farrell²,

MacWilliam

et al. 1998

PEDIATRICS

View full text Add to dashboard Cite

ABSTRACT. Rationale. Human herpesvirus 6 (HHV-6) has been demonstrated to be the causative agent in roseola infantum. It has been suggested that HHV-6 may have neurotropic properties and be involved in the pathogenesis of febrile seizures in infants. We describe a case-control study to examine the hypothesis that acute HHV-6 infection occurs more commonly in children with febrile seizures than in controls.Methods. Patients presenting with a first or second febrile seizure between 6 months and 2 years of age were entered in the study. Control patients did not have a seizure but had similar inclusion and exclusion criteria. Specimens were obtained for HHV-6 viral serology and polymerase chain reaction in the acute stage and approximately 2 weeks later. A diagnosis of HHV-6 infection was based on HHV-6-specific IgM and IgG serology and HHV-6 polymerase chain reaction of peripheral blood mononuclear cells and saliva.Results. Eighty-six patients (45 with febrile seizures; 41 controls) were enrolled. The HHV-6 infection status could be determined in only 68 patients (35 with febrile seizures; 33 controls). Acute HHV-6 infection was identified in 15 of 35 febrile seizure patients and in 15 of 33 controls. Evidence of past HHV-6 infection was demonstrated in 13 febrile seizure patients and in 8 controls.Conclusions. The incidence of primary HHV-6 infection is similar in patients with febrile seizures and agematched controls. HHV-6 does not seem to be a major factor in the pathogenesis of first and second febrile seizures. Pediatrics 1998;101(2). URL: http://www. pediatrics.org/cgi/content/full/101/2/e3; human herpesvirus 6, febrile seizures, case-control.ABBREVIATIONS. HHV-6, human herpesvirus 6; RI, roseola infantum; CSF, cerebrospinal fluid; PCR, polymerase chain reaction; PBMN, peripheral blood mononuclear cells; HSV, herpes simplex virus; CMV, cytomegalovirus; EBV, Epstein-Barr virus; ELISA, enzyme-linked immunosorbent assay; IFA, immunofluorescent assay. H uman herpesvirus 6 (HHV-6), a lymphotropic virus, is the causative agent of roseola infantum (RI).1,2 HHV-6 infection is more often associated with a nonspecific febrile illness between 6 months and 2 years of life.3 Seroprevalence studies in Japan, England, and the United States demonstrate that infection with HHV-6 is common.4 -6 HHV-6-specific IgG can be detected in almost all newborns, but the prevalence declines to less than 10% by 4 to 5 months of age, presumably as maternal antibody wanes. 4 The seroprevalence increases to 65% by 1 year of age 6 and to greater than 90% by 13 to 36 months of age. 4,6,7 Accumulating clinical and laboratory evidence suggests that HHV-6, like all other herpesviruses, may have neurotropic properties. RI may be complicated by seizures, encephalopathy, aseptic meningitis, meningoencephalitis, and hemiplegia. Febrile seizures are the commonest cause of seizures in early childhood and present before 3 years of age in more than 80% of patients. 21,22 A family history of seizures, usually febrile seizures, is observed in 30% to 50% o...

show abstract

mentioning

confidence: 99%

“…4 The seroprevalence increases to 65% by 1 year of age 6 and to greater than 90% by 13 to 36 months of age. 4,6,7 Accumulating clinical and laboratory evidence suggests that HHV-6, like all other herpesviruses, may have neurotropic properties. RI may be complicated by seizures, encephalopathy, aseptic meningitis, meningoencephalitis, and hemiplegia.…”

mentioning

confidence: 99%

Case-Control Study of Primary Human Herpesvirus 6 Infection in Children With Febrile Seizures

Hukin

Farrell²,

MacWilliam

et al. 1998

PEDIATRICS

View full text Add to dashboard Cite

show abstract

“…Epidemiologic studies in normal children have shown that the vast majority of primary HHV-6 infections occur within the ®rst year of life Farr et al, 1990). Human herpesvirus-6 IgG can be detected in more than 90% of neonates (Knowles and Gardner, 1988;Leach et al, 1992), re¯ecting both the high seroprevalence of HHV-6 among adults (Brown et al, 1988b;Ranger et al, 1991;Leach et al, 1992) and the active transport of HHV-6 IgG across the placenta . The prevalence of HHV-6 IgG drops signi®cantly by 4 ± 6 months of life as maternal antibodies decline, then increases through the third year of life and remains high into adulthood Farr et al, 1990).…”

Section: Epidemiologymentioning

confidence: 99%

Human Herpesvirus-6: Neurologic Implications of a Newly-Described Viral Pathogen

Kimberlin

Whitley

1998

J Neurovirol

View full text Add to dashboard Cite

Discovered only 12 years ago, human herpesvirus-6 (HHV-6) has been associated with central nervous system (CNS) ®ndings such as febrile seizures, encephalitis, meningitis, and possibly multiple sclerosis. These manifestations have been reported in both immunocompetent and immunocompromised individuals. The applications of such sophisticated laboratory tools as polymerase chain reaction, in situ hybridization, immunohistochemical staining, and representational difference analysis have expanded knowledge of the spectrum of CNS disease attributable to HHV-6 while delineating pathogenic mechanisms of both primary HHV-6 infection and reactivation from latency. This article reviews existing knowledge of the CNS manifestations of HHV-6, focusing on both clinical aspects of HHV-6 infection and its pathogenesis on neurologic diseases.

show abstract

“…Most people experience primary HHV-6 infection by the age of 3 years (5,29). Reactivation of or reinfection with the virus may cause opportunistic diseases in immunocompromised hosts (9,27,42).…”

mentioning

confidence: 99%

Human Herpesvirus 6 Infection of CD4⁺ T‐Cell Subsets

Otani

Okuno

2007

Microbiology and Immunology

View full text Add to dashboard Cite

The immune system includes CD4+ regulatory T (Treg) cells that play a role in self‐tolerance and demonstrate functional variations that govern immune responses. HHV‐6 is an important immunosuppressive virus that completely replicates in vivo and in vitro in only CD4+ T cells. However, there have been no reports of the specific T‐cell subpopulation that permits the replication of this virus. Here, we evaluated the infectivity of HHV‐6 to specific T‐cell populations such as CD4+CD25high, which includes the majority of Treg cells, and CD4+CD25–. These cells were isolated from peripheral blood and then expanded. The expanded cell fractions were then infected with the HHV‐6 variant B strain, and the spreads of infected cells were evaluated by immunofluorescence. Viral growth was also quantified by real‐time PCR. The effects of virus infection on cytokine production from these T‐cell subsets were examined using ELISA. Our results revealed that both these fractions permitted complete HHV‐6 replication. Virus infection enhanced the production of both Th1‐ and Th2‐type cytokines from CD4+CD25– T cells; however, only Th2‐type cytokine release was augmented from viral‐infected CD4+CD25high T cells. Further, while virus‐infected CD4+CD25high T cells shift their antiviral immunity toward Th2 dominance by producing IL‐10, the role of virus‐infected CD4+CD25– T cells remains obscure.

show abstract

Fall in Human Herpesvirus 6 Seropositivity With Age

Cited by 111 publications

References 6 publications

Case-Control Study of Primary Human Herpesvirus 6 Infection in Children With Febrile Seizures

Case-Control Study of Primary Human Herpesvirus 6 Infection in Children With Febrile Seizures

Human Herpesvirus-6: Neurologic Implications of a Newly-Described Viral Pathogen

Human Herpesvirus 6 Infection of CD4⁺ T‐Cell Subsets

Contact Info

Product

Resources

About

Fall in Human Herpesvirus 6 Seropositivity With Age

Cited by 111 publications

References 6 publications

Case-Control Study of Primary Human Herpesvirus 6 Infection in Children With Febrile Seizures

Case-Control Study of Primary Human Herpesvirus 6 Infection in Children With Febrile Seizures

Human Herpesvirus-6: Neurologic Implications of a Newly-Described Viral Pathogen

Human Herpesvirus 6 Infection of CD4+ T‐Cell Subsets

Contact Info

Product

Resources

About

Human Herpesvirus 6 Infection of CD4⁺ T‐Cell Subsets