False-Negative FDG PET Imaging in a Patient With Metastatic Melanoma and Ileal Intussusception

Alibazoglu, Haluk; Alibazoglu, Buket; Aamar, Ali; G, La Monica

doi:10.1097/00003072-199902000-00015

Cited by 5 publications

(3 citation statements)

References 3 publications

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“…The usefulness of FDG-PET in recurrent tumors other than these primary tumors of the esophagus, stomach, and intestine has also reported [15,16], encouraging expectations that FDG-PET will also be useful for the detection of metastatic tumors of the gastrointestinal tract. A few studies have reported metastatic tumors of the gastrointestinal tract and the use of FDG-PET in gastrointestinal metastases [17,18]. Studies have reported on 124 patients with gastrointestinal metastasis from lung cancer, 106 of whom were diagnosed on the occasion of serious complications such as perforation [3,19].…”

Section: Casementioning

confidence: 99%

Metastasis of the gastrointestinal tract: FDG-PET imaging

et al. 2007

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We assess the usefulness of F-18-fluoro-deoxyglucose (FDG) positron emission tomography (PET) in the evaluation of gastrointestinal metastases. Four cases (five lesions) in which metastases from three lung cancers and one malignant fibrous histiocytoma (MFH) of the femur were found in the gastrointestinal tract were reviewed (men/women 3 : 1, age 63-78 years, mean 72 years). The five lesions were duodenal, jejunal metastasis, and two stomach metastases from lung carcinoma, and rectal metastasis from MFH of the femur. FDG-PET was unable to detect small masses, but it was able to detect unforeseen lesions such as gastrointestinal metastases because FDG-PET is a whole-body scan in a single-operation examination. FDG-PET imaging provided valuable information for the diagnosis of gastrointestinal metastasis.

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Section: Casementioning

confidence: 99%

Metastasis of the gastrointestinal tract: FDG-PET imaging

et al. 2007

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“…However, epigastric pain, chronic bleeding, nausea and vomiting, melena and weight loss are commonly reported and constipation, abdominal satiety and hematemesis also occur. Common complications include perforation, obstruction and ulceration due to disease progression (45,46). In patients at extensive-stages of the disease, chemotherapy is the preferred therapeutic option to attenuate symptoms and prolong survival in patients; however, long-term survival is rare (9).…”

Section: Discussionmentioning

confidence: 99%

Pathological diagnosis and treatment outcome of gastric metastases from small cell lung cancer: A case report

et al. 2019

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Small cell lung cancer (SCLC) is a type of lung cancer characterized by a rapid disease progression and poor prognosis. Its diagnosis is often accompanied by distant metastasis. A literature review revealed that metastases to the stomach from breast, lung and esophageal cancer are frequently reported. While SCLC is a common pathological subtype of lung cancer, literature on SCLC with gastric metastases is sporadic. The present study reviewed the literature using databases, including PubMed, WanFang Data and China National Knowledge Infrastructure, to analyze the clinicopathological features and outcome of patients with gastric metastases from SCLC. A total of 11 case reports and 6 retrospective studies comprising of 19 cases were compared and analyzed. In addition to the aforementioned studies, a case study describing a patient who survived for 10 months following a diagnosis of SCLC with gastric metastases is presented. The aim of the present study was to increase the understanding regarding the diagnosis and treatment of SCLC gastric metastasis.

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“…There are reports of PET-negative cases of melanoma metastasis in the literature which are noteworthy. Thus and in regard of the before-mentioned highly suspicious FNA specimen, our local tumor board did not advise conducting a PET/CT, since it would have had no significant clinical impact on management decisions [ 30 – 32 ]. Image-guided FNA can be useful in the process of diagnostic evaluation and averting splenectomy but carries the risk of bleeding, non-diagnostic biopsies, and needle tract seeding in cases of malignoma.…”

Section: Discussionmentioning

confidence: 99%

Sclerosing angiomatoid nodular transformation of the spleen mimicking metastasis of melanoma: a case report and review of the literature

et al. 2017

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BackgroundSclerosing angiomatoid nodular transformation is a benign disorder of splenic tissue and is often mistaken as a potentially malignant entity in the diagnostic process. To the best of our knowledge, this is the first report of sclerosing angiomatoid nodular transformation mimicking metastasis of melanoma in the literature.Case presentationA 43-year-old white man presented with a newly found splenic mass 4 years ago to our Department of Gastroenterology. He was diagnosed as having a superficial spreading malignant melanoma localized at his left instep 7 years ago and was successfully treated with radical local resection. Several diagnostic procedures were conducted. Ultrasound showed a hypoechoic lesion in the inferior pole of his spleen with a diameter of 2 cm, blurred boundaries, and inhomogeneous interior pattern. Contrast-enhanced ultrasound was inconclusive and showed only discrete contrast enhancement of the lesion with accentuated nodule-like enrichment of the boundaries in the arterial phase. Computed tomography and magnetic resonance imaging scans showed two splenic lesions which were highly suspicious of metastasis. Magnetic resonance imaging of his head was inconspicuous. Bone scintigraphy showed no abnormal results. Fine-needle aspiration indicated metastasis of the above-mentioned malignant melanoma. We conducted a laparoscopic splenectomy. His intraoperative and postoperative course were uneventful. In contrast to the result of the fine-needle aspiration, the presence of metastasis of melanoma could not be confirmed. Histological analysis revealed nodule-like arrangement of fibroblasts with low cell density and a predominance of dilated capillaries, indicating sclerosing angiomatoid nodular transformation of the spleen.ConclusionsThere are no preoperative diagnostic imaging procedures which can definitely differentiate sclerosing angiomatoid nodular transformation from malignancies in cases of morphological and immunophenotypic variations of the specimen. Morphological and immunophenotypic variations of the specimen represent a diagnostic challenge and can mimic malignoma. As reported in our case, the specimen obtained by ultrasound-guided fine-needle aspiration led to the diagnosis of metastasis of melanoma. Splenectomy is often conducted due to a splenic mass suspicious of malignoma as described in our case or with unknown valency in different diagnostic imaging procedures.

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False-Negative FDG PET Imaging in a Patient With Metastatic Melanoma and Ileal Intussusception

Cited by 5 publications

References 3 publications

Metastasis of the gastrointestinal tract: FDG-PET imaging

Metastasis of the gastrointestinal tract: FDG-PET imaging

Pathological diagnosis and treatment outcome of gastric metastases from small cell lung cancer: A case report

Sclerosing angiomatoid nodular transformation of the spleen mimicking metastasis of melanoma: a case report and review of the literature

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