Familial Brain Tumors

Tijssen, Cornelis C.; Halprin, Michael R.; Endtz, L.J.

doi:10.1007/978-94-009-7600-9

Cited by 12 publications

(2 citation statements)

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“…Using these figures, the odds of three siblings developing astrocytomas as random events have been estimated to be about 1 in 2 million [11]. In our series three of 32 patients with astrocytomas had first degree relatives with astrocytomas.…”

Section: Discussionmentioning

confidence: 95%

“…Although all of the affected members of this family lived temporarily in one household, their malignancies did not occur in close temporal proximity, and no specific environmental causes were identified. Tijssen et al has compiled provocative histories of families with brain tumors and suggests that genetic factors may be related to the genesis of high grade astrocytomas [11].…”

Section: Discussionmentioning

confidence: 99%

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Familial clustering of malignant astrocytomas

Lossignol¹,

Grossman²,

Sheidler³

et al. 1990

J Neuro-Oncol

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Three of 32 consecutive patients with astrocytomas enrolled in an experimental chemotherapy protocol had at least one first degree relative with an astrocytoma. These patients did not have family members with an excess of malignancies, known exposure to a specific environmental factor, or a recognized neurocutaneous syndrome. In all three families, the illnesses temporally overlapped and the age of the patients affected in the second generation was less than those in the first generation. An estimation of the probability of developing astrocytomas in families with one affected individual strongly suggests a familial effect. Our observations, coupled with other cases reported in the literature, suggest that familial astrocytomas occur more frequently than is currently recognized. Identification and careful study of such families may provide important clues to the etiology of these malignancies.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Familial clustering of malignant astrocytomas

Lossignol¹,

Grossman²,

Sheidler³

et al. 1990

J Neuro-Oncol

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Familial factors associated with malignant gliomas

1990

Genetic Epidemiology

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Family histories of male patients with histologically confirmed malignant gliomas were compared to family histories of controls (wives). Included were 77 case families with 892 relatives and 77 control families with 719 relatives. Cases had significantly more siblings than controls (P = 0.02), although cases were not preferentially the oldest or the youngest sibs. Odds ratios of two or more were found for mental retardation, Parkinson's disease, and meningitis for the relatives of cases versus controls, but none were statistically significant. The excesses of Parkinson's disease and meningitis were explained by the family of one particularly interesting case containing three relatives with meningitis and two relatives with Parkinson's disease. Noteworthy age-adjusted odds ratios for cancer among relatives of cases compared to relatives of controls were 1.6 (95% confidence interval (CI) = 1.0-2.3) for cancer of any site, 2.4 (95% CI = 0.8-6.1) for breast cancer, and 4.0 (95% CI = 0.6-10.7) for lung cancer. Only the odds ratio for cancer of any site was statistically significant. Overall, 6 of 77 (8%) of cases came from families that included two or more relatives with breast or lung cancer in addition to the proband with malignant glioma. These three cancer sites may form familial clusters worthy of further evaluation in future studies by pedigree and genetic linkage analyses.

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Medulloblastoma, Primitive Neuroectodermal Tumors, and Pineal Tumors

Sandberg¹,

Stone²

The Genetics and Molecular Biology of Neural Tumors

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Familial Brain Tumors

Cited by 12 publications

References 0 publications

Familial clustering of malignant astrocytomas

Familial clustering of malignant astrocytomas

Familial factors associated with malignant gliomas

Medulloblastoma, Primitive Neuroectodermal Tumors, and Pineal Tumors

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