Familial Elevated Factor VIII in Children With Symptomatic Venous Thrombosis and Post-Thrombotic Syndrome

Kreuz, W.; Stoll, Monika; Junker, Ralf; Heinecke, Achim; Schobeß, R.; Kurnik, Karin; Kelsch, Reinhard; Nowak‐Göttl, Ulrike

doi:10.1161/01.atv.0000227510.36653.ed

Cited by 71 publications

(86 citation statements)

References 42 publications

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“…164 Among a total of 977 patients with UEDVT/lower-extremity DVT, the weighted mean frequency of PTS was 26% (95% CI, [23][24][25][26][27][28]. When restricted to the 9 prospective analyses, [165][166][167][168][169][170][171][172][173] this frequency was 17% (95% CI, [14][15][16][17][18][19][20]. Only 1 prospective study has subsequently been published, in which the cumulative incidence of PTS was 23% after a follow-up period ranging from 1 to 5 years.…”

Section: Pediatric Ptsmentioning

confidence: 99%

The Postthrombotic Syndrome: Evidence-Based Prevention, Diagnosis, and Treatment Strategies

Kahn¹,

Comerota²,

Cushman³

et al. 2014

Circulation

499

410

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Section: Pediatric Ptsmentioning

confidence: 99%

The Postthrombotic Syndrome: Evidence-Based Prevention, Diagnosis, and Treatment Strategies

Kahn¹,

Comerota²,

Cushman³

et al. 2014

Circulation

499

410

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“…A flow chart of search results and their distribution by category of publication is provided in Figure 1, showing both included [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] and excluded reports. Nineteen original reports met eligibility criteria (Table 1); no systematic reviews were identified.…”

Section: Overall Search Resultsmentioning

confidence: 99%

“…In evaluating PTS, five studies 8,13,14,18,20 used a pediatric modification 8 of the Villalta scoring system for PTS in adults, 73 two studies 11,16 Reviews/commentaries (n=16) Not pediatric (n=13) Not VTE (n=8) Not followed for PTS (n=4) Single case reports (n=3) Cases selected due to PTS (n=2)…”

Section: Overall Search Resultsmentioning

confidence: 99%

Post-thrombotic syndrome in children: a systematic review of frequency of occurrence, validity of outcome measures, and prognostic factors

Goldenberg¹,

Donadini²,

Kahn³

et al. 2010

Haematologica

181

149

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BackgroundPost-thrombotic syndrome is a manifestation of chronic venous insufficiency following deep venous thrombosis. This systematic review was conducted to critically evaluate pediatric evidence on frequency of occurrence, validity of outcome measures, and prognostic indicators of post-thrombotic syndrome. Design and MethodsA comprehensive literature search of original reports revealed 19 eligible studies, totaling 977 patients with upper/lower extremity deep venous thrombosis. Calculated weighted mean frequency of post-thrombotic syndrome was 26% (95% confidence interval: 23-28%) overall, and differed significantly by prospective/non-prospective analysis and use/non-use of a standardized outcome measure. ResultsStandardized post-thrombotic syndrome outcome measures included an adaptation of the Villalta scale, the Clinical-Etiologic-Anatomic-Pathologic classification, and the Manco-Johnson instrument. Data on validity were reported only for the Manco-Johnson instrument. No publications on post-thrombotic syndrome-related quality of life outcomes were identified. Candidate prognostic factors for post-thrombotic syndrome in prospective studies included use/non-use of thrombolysis and plasma levels of factor VIII activity and D-dimer. ConclusionsGiven that affected children must endure chronic sequelae for many decades, it is imperative that future collaborative pediatric prospective cohort studies and trials assess as key objectives and outcomes the incidence, severity, prognostic indicators, and health impact of post-thrombotic syndrome, using validated measures.

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“…Other pediatric reports describing the occurrence of PTS following LE-DVT reported a frequency ranging from 8.5% to 78%. It must be pointed out that these studies include either patients with VTE affecting different territories (ie, including organs), 2,[18][19][20] patients with UE and LE-DVT, 13,21 or patients with LE-DVT only. 8,22 Besides the difference in the studied populations, these reports also differ in their PTS assessment approach, and usually combine LR and Non-LR events.…”

Section: Org Frommentioning

confidence: 99%

Postthrombotic syndrome and other outcomes of lower extremity deep vein thrombosis in children

Avila¹,

Pullenayegum

Williams³

et al. 2016

Blood

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Key Points• The frequency of PTS, PE, and DVT recurrence was higher in children with Non-LR DVT than in children with LR DVT.• Thrombus resolution, DVT triggering event, and sex were predictors of LE PTS in children.Pediatric lower extremity deep vein thrombosis (LE-DVT) can lead to postthrombotic syndrome (PTS) and other adverse events. We investigated the outcomes of LE-DVT in children. Three groups were compared: non-line-related (Non-LR) DVT, LR DVT in neonates (LR neonates ), and LR DVT in non-neonates (LR non-neonates ). A total of 339 children were included (Non-LR, n 5 56; LR neonates , n 5 95; and LR non-neonates , n 5 188). We found a statistically significant difference in the frequency of PTS (P 5 .04; 62.5%, 40.0%, and 46.3% in Non-LR, LR neonates , and LR non-neonates, respectively), of recurrent LE-DVT (P 5 .001; 10.7% and 2.0% in Non-LR and LR non-neonates, respectively), and pulmonary embolism (PE) (P < .001; 19.6% and 3.2% in Non-LR and LR non-neonates, respectively) among groups. There was no difference in DVT resolution (P 5 .41). Multivariable analysis showed that DVT resolution, triggering event, and sex predicted Modified Villalta Scale (MVS; for pediatric PTS) scores >1; there was an interaction between DVT triggering event and sex. The time to reach an MVS >1 was significantly different when comparing groups (log-rank test, P < .001). Moreover, we found a significant difference in baseline MVS scores among groups, but the difference did not appear to change over time. In conclusion, LR LE-DVT had more benign outcomes than Non-LR DVT. Sex, DVT triggering event, and DVT resolution predicted

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Familial Elevated Factor VIII in Children With Symptomatic Venous Thrombosis and Post-Thrombotic Syndrome

Cited by 71 publications

References 42 publications

The Postthrombotic Syndrome: Evidence-Based Prevention, Diagnosis, and Treatment Strategies

The Postthrombotic Syndrome: Evidence-Based Prevention, Diagnosis, and Treatment Strategies

Post-thrombotic syndrome in children: a systematic review of frequency of occurrence, validity of outcome measures, and prognostic factors

Postthrombotic syndrome and other outcomes of lower extremity deep vein thrombosis in children

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