Familial Intestinal Polyposis

Dukes, Cuthbert E.

doi:10.1111/j.1469-1809.1953.tb02531.x

Cited by 68 publications

(21 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with PAF were asymptomatic within the pediatric age group, with only rare symptomatic cases before the second decade of life (10,11) , when the main manifestation appears as intermittent rectal bleeding, followed by abdominal pain, anemia, and diarrhea, which is similar to that found in the present case series. Benign extracolonic manifestations, such as congenital hypertrophy of the retina, epidermoid cysts, and osteomas, may also be present (15,35) , a fact also proven in the present case series.…”

Section: Discussionsupporting

confidence: 87%

Clinical, Epidemiologic, and Endoscopic Profile in Children and Adolescents With Colonic Polyps in Two Reference Centers

Andrade

Ferreira

Bittencourt

et al. 2015

Arq. Gastroenterol.

View full text Add to dashboard Cite

-Background -The main goal of this paper is to investigate the frequency, clinical profile, and endoscopic findings of children and teenagers submitted to colonoscopies. Methods -Patients of below 18 years of age, diagnosed with polyps by means of colonoscopies at two reference centers of pediatric endoscopy were followed-up between 2002 and 2012. The clinical variables evaluated in this study included: gender, recommendation of colonoscopy, associated signs and symptoms, age of onset of symptoms, age at identification of the polyp, interval of time between the onset of symptoms and the endoscopic diagnosis of colonic polyps, and family history of intestinal polyposis and/or colorectal cancer. The characteristics of the polyps also included: number, morphological type, histology, and distribution. Polyposis syndromes were also investigated. Results -From the 233 patients submitted to colonoscopies, polyps were found in 74 (31.7%) patients, with a median age of 6.6 years, of which 61% were male. Juvenile polyps were identified in 55 (74%) patients, with 7 (9%) characterized within the criteria for juvenile polyposis. Patients with intestinal polyposis syndromes were diagnosed in 35% of the patients. The most frequent clinical presentation was hematochezia. Abdominal pain with acute episodes of intestinal partial obstruction or intussusception with emergency laparotomy was observed in the majority of Peutz-Jeghers syndrome patients leading to an increased morbidity. Conclusions -Even though juvenile colonic polyps are the most frequent type of diagnosed polyps, the present study identified a significant level of children with polyposis syndromes (35%), associated with a higher morbidity of these individuals.

show abstract

Section: Discussionsupporting

confidence: 87%

Clinical, Epidemiologic, and Endoscopic Profile in Children and Adolescents With Colonic Polyps in Two Reference Centers

Andrade

Ferreira

Bittencourt

et al. 2015

Arq. Gastroenterol.

View full text Add to dashboard Cite

show abstract

“…Familial polyposis is an unusual but thoroughly described genetically determined cancer syndrome [4,6,7,10,. Maintaining an awareness of this problem will reduce potential hazards for untreated relatives.…”

Section: Introductionmentioning

confidence: 99%

Villous adenomatosis and carcinoma in a 66‐year‐old man with familial polyposis

Roseman

Clausen

Minton

1982

Journal of Surgical Oncology

View full text Add to dashboard Cite

A patient evaluated and treated for carcinoma of the colon and multiple polyps and the patient's family represent a new pattern of clinical and pathologic manifestations of familial polyposis. The lack of antecedent family history of polyposis, the presence of diffuse villous degeneration, and the occurrence of cancer at age 66 years are departure from the usual character of this syndrome. Subsequent generations continued the expression of familial polyposis with prominent villous changes. New insight into a possible relationship among the various types of polyps as well as between them and cancer is suggested by this family.

show abstract

“…This fact seems to have escaped the attention of many writers on the subject, and although Dukes (1952) recorded two instances of "skipping" he did not comment upon it. In one of these the maternal grandfather of two polyposis patients died from cancer of the colon (according to the testimony of relatives) whereas the mother died at the age of 42 from pneumonia.…”

mentioning

confidence: 99%

“…VEALE features. Dukes (1952) described fully the course of the disease and recorded details of 22 families in which there was more than one member affected. In addition there were eight families in which the details were incomplete and 11 families in which there was only one affected member.…”

mentioning

confidence: 99%

Clinical and Genetic Problems in Familial Intestinal Polyposis

Veale¹

1960

Gut

View full text Add to dashboard Cite

Familial Intestinal Polyposis

Cited by 68 publications

References 35 publications

Clinical, Epidemiologic, and Endoscopic Profile in Children and Adolescents With Colonic Polyps in Two Reference Centers

Clinical, Epidemiologic, and Endoscopic Profile in Children and Adolescents With Colonic Polyps in Two Reference Centers

Villous adenomatosis and carcinoma in a 66‐year‐old man with familial polyposis

Clinical and Genetic Problems in Familial Intestinal Polyposis

Contact Info

Product

Resources

About