Far-infrared radiation effect on the structure and properties of proteins

Govorun, Vadim M.; Tretiakov, V. E.; Tulyakov, N. N.; Fleurov, Vladimir B.; Demin, A. I.; Volkov, A. Yu.; Batanov, V. A.; Капитанов, А. Б.

doi:10.1007/bf01883879

Cited by 21 publications

(9 citation statements)

References 6 publications

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“…In 1991, Govurun et al performed a set of experiments to examine the effect that THz radiation has on several biomolecules, including albumin, alcohol dehydrogenase, peroxidase, and trypsin [180]. The authors exposed biomolecules to irradiation using a FIR THz source with the following operating conditions: 3.33 THz, 5 mJ per pulse, 40-600 pulses, and a total energy of 0.2 to 3 J.…”

Section: Enzyme Activitymentioning

confidence: 99%

Invited Review Article: Current State of Research on Biological Effects of Terahertz Radiation

Wilmink

Grundt

2011

J Infrared Milli Terahz Waves

277

186

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In recent years, terahertz radiation sources are increasingly being exploited in military and civil applications. However, only a few studies have so far been conducted to examine the biological effects associated with terahertz radiation. In this study, we evaluated the cellular response of mesenchymal mouse stem cells exposed to THz radiation. We apply low-power radiation from both a pulsed broad-band (centered at 10 THz) source and from a CW laser (2.52 THz) source. Modeling, empirical characterization, and monitoring techniques were applied to minimize the impact of radiation-induced increases in temperature. qRT-PCR was used to evaluate changes in the transcriptional activity of selected hyperthermic genes. We found that temperature increases were minimal, and that the differential expression of the investigated heat shock proteins (HSP105, HSP90, and CPR) was unaffected, while the expression of certain other genes (Adiponectin, GLUT4, and PPARG) showed clear effects of the THz irradiation after prolonged, broad-band exposure.

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Section: Enzyme Activitymentioning

confidence: 99%

Invited Review Article: Current State of Research on Biological Effects of Terahertz Radiation

Wilmink

Grundt

2011

J Infrared Milli Terahz Waves

277

186

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“…Studies have reported that terahertz wave radiation alters the activity and expression of proteins, which is closely associated with radiation intensity [ 38 ]. Titova et al [ 39 ] found that the levels of tumor suppressor proteins, cell cycle regulatory proteins, and damage repair proteins were upregulated in artificial human skin tissues after exposure to terahertz waves with a strong pulse of (0.1–1.0) μJ.…”

Section: Effects Of Terahertz Wave On Biomacromoleculesmentioning

confidence: 99%

Research progress in the effects of terahertz waves on biomacromolecules

2021

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With the rapid development of terahertz technologies, basic research and applications of terahertz waves in biomedicine have attracted increasing attention. The rotation and vibrational energy levels of biomacromolecules fall in the energy range of terahertz waves; thus, terahertz waves might interact with biomacromolecules. Therefore, terahertz waves have been widely applied to explore features of the terahertz spectrum of biomacromolecules. However, the effects of terahertz waves on biomacromolecules are largely unexplored. Although some progress has been reported, there are still numerous technical barriers to clarifying the relation between terahertz waves and biomacromolecules and to realizing the accurate regulation of biological macromolecules by terahertz waves. Therefore, further investigations should be conducted in the future. In this paper, we reviewed terahertz waves and their biomedical research advantages, applications of terahertz waves on biomacromolecules and the effects of terahertz waves on biomacromolecules. These findings will provide novel ideas and methods for the research and application of terahertz waves in the biomedical field.

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“…a dose-dependent change in the activity of alcohol dehydrogenase from yeast, horseradish peroxidase, and BSA. 216 …”

Section: Terahertz Exposure Of Biological Objects With Different Levels Of Organizationmentioning

confidence: 99%

Cellular effects of terahertz waves

et al. 2021

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. Significance: An increasing interest in the area of biological effects at exposure of tissues and cells to the terahertz (THz) radiation is driven by a rapid progress in THz biophotonics, observed during the past decades. Despite the attractiveness of THz technology for medical diagnosis and therapy, there is still quite limited knowledge about safe limits of THz exposure. Different modes of THz exposure of tissues and cells, including continuous-wave versus pulsed radiation, various powers, and number and duration of exposure cycles, ought to be systematically studied. Aim: We provide an overview of recent research results in the area of biological effects at exposure of tissues and cells to THz waves. Approach: We start with a brief overview of general features of the THz-wave–tissue interactions, as well as modern THz emitters, with an emphasis on those that are reliable for studying the biological effects of THz waves. Then, we consider three levels of biological system organization, at which the exposure effects are considered: (i) solutions of biological molecules; (ii) cultures of cells, individual cells, and cell structures; and (iii) entire organs or organisms; special attention is devoted to the cellular level. We distinguish thermal and nonthermal mechanisms of THz-wave–cell interactions and discuss a problem of adequate estimation of the THz biological effects’ specificity. The problem of experimental data reproducibility, caused by rareness of the THz experimental setups and an absence of unitary protocols, is also considered. Results: The summarized data demonstrate the current stage of the research activity and knowledge about the THz exposure on living objects. Conclusions: This review helps the biomedical optics community to summarize up-to-date knowledge in the area of cell exposure to THz radiation, and paves the ways for the development of THz safety standards and THz therapeutic applications.

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Far-infrared radiation effect on the structure and properties of proteins

Cited by 21 publications

References 6 publications

Invited Review Article: Current State of Research on Biological Effects of Terahertz Radiation

Invited Review Article: Current State of Research on Biological Effects of Terahertz Radiation

Research progress in the effects of terahertz waves on biomacromolecules

Cellular effects of terahertz waves

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