FAR Ratio as Prognostic Biomarker in AMI

Abstract

Acute mesenteric ischemia (AMI) is a vascular emergency resulting from decreased blood flow caused by the occlusion of the mesenteric vessels, hypoperfusion, or vasospasm. This study aimed to investigate the prognostic value of the fibrinogen-to-albumin (FAR) ratio in patients with acute mesenteric ischemia. A total of 91 patients were enrolled in the study. Patients’ demographics such as age and gender, pre- and postoperative hemoglobin, CRP, white blood cell (WBC), neutrophils, preoperative lymphocyte, alanine transaminase (ALT), aspartate transaminase (AST), thrombocytes, and postoperative D-dimer values were recorded. In addition, pre- and postoperative fibrinogen and albumin levels were recorded, and FAR was calculated. Patients were divided into two groups, survivors and non-survivors. The mean pre- and postoperative fibrinogen levels were statistically significantly higher in the non-survivor group than in the survivor group ( p < 0.001). The mean pre- and postoperative albumin levels were significantly lower in the non-survivors than in the survivors ( p = 0.059, p < 0.001; respectively). The mean pre- and postoperative FAR ratios were considerably higher in the non-survivor than in the survivor groups ( p < 0.001). The change between pre- and postoperative fibrinogen, albumin, and FAR values was statistically significant between the non-survivors and the survivors (for all, p < 0.05). The preoperative and postoperative fibrinogen levels were significantly lower, and albumin levels were significantly higher in the survivor compared to the non-survivor patients with AMI. Furthermore, the preoperative and postoperative FAR ratio was significantly higher in the non-survivors. The FAR ratio may be a valuable prognostic biomarker for patients with AMI.

The Efficiency of Serum Biomarkers in Predicting the Clinical Outcome of Patients with Mesenteric Ischemia during Follow-Up: A Systematic Review

“…According to Muhtaro glu et al, postoperative CRP levels were statistically significantly higher in the nonsurvivor group (p < 0.05). Preoperative CRP levels were not statistically significantly higher in the non-survivor group [28]. On the other hand, in a previous study by Destek et al, CRP levels were used efficiently in the operative period to diagnose AMI and characterize its subtype and clinical course.…”

“…The non-survivor group's preoperative WBC and neutrophil count were statistically significantly higher. Additionally, the non-survivor group had statistically higher postoperative CRP and D-dimer levels [28].…”

“…Muhtaro glu et al investigated the prognostic value of FAR for the first time in patients with AMI and concluded that it may be a valuable prognostic biomarker. In the logistic regression analysis, the postoperative FAR value affected survival, while preoperative FAR did not [28]. The mean pre-and postoperative values of other variables were also examined.…”