2020
DOI: 10.1186/s12974-020-01838-w
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Farnesoid X receptor knockout protects brain against ischemic injury through reducing neuronal apoptosis in mice

Abstract: Background Farnesoid X receptor (FXR) is a nuclear receptor that plays a critical role in controlling cell apoptosis in diverse diseases. Previous studies have shown that knocking out FXR improved cardiac function by reducing cardiomyocyte apoptosis in myocardial ischemic mice. However, the role of FXR after cerebral ischemia remains unknown. In this study, we explored the effects and mechanisms of FXR knockout (KO) on the functional recovery of mice post cerebral ischemia-reperfusion. … Show more

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Cited by 31 publications
(19 citation statements)
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“…Subsequently, the samples were cut into 30 μm sections from the anterior commissure to the hippocampus and stained with 1% cresyl violet. The atrophy area ΔS was calculated as the contralateral area minus the ipsilateral area, and the atrophy volume was calculated as: V = h / 3 [ ΔSn + + ΔSn+1], where “h” represents the thickness between the two sections 23 .…”
Section: Methodsmentioning
confidence: 99%
“…Subsequently, the samples were cut into 30 μm sections from the anterior commissure to the hippocampus and stained with 1% cresyl violet. The atrophy area ΔS was calculated as the contralateral area minus the ipsilateral area, and the atrophy volume was calculated as: V = h / 3 [ ΔSn + + ΔSn+1], where “h” represents the thickness between the two sections 23 .…”
Section: Methodsmentioning
confidence: 99%
“…where V indicates volume, h indicates the distance between the two adjacent sections, contralateral area subtracts normal area of the ipsilateral hemisphere was calculated as the infarct area ΔS, andΔ ;Sn and Δ Sn+1 indicates the different area between the two adjacent sections [ 77 ].…”
Section: Methodsmentioning
confidence: 99%
“…The tMCAO model was induced by endovascular occlusion of the right middle cerebral artery using a monofilament (Doccol Corporation, Sharon, MA, USA) for 90 min and was performed under the control of magnetic resonance imaging (MRI), as described previously [22]. Ninety-minute tMCAO in rodents is an adequate duration of occlusion and has been used in numerous studies of the molecular mechanisms of ischemia-reperfusion (IR) damage and the effects of neuroprotective agents on the infarct area [47][48][49][50].…”
Section: The Tmcao Model and Semax Administrationmentioning
confidence: 99%