Farnesol brain transcriptomics in CNS inflammatory demyelination

Doyle, William J.; Walters, Dana; Shi, Xutong; Hoffman, Kristina; Magori, Krisztian; Roullet, Jean-Baptiste; Ochoa-Repáraz, Javier

doi:10.1016/j.clim.2023.109752

Cited by 5 publications

(1 citation statement)

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“…The miscellaneous effects of farnesol have been primarily reported in animal studies. The topical or oral administration of farnesol as a dietary supplement was reported to exert beneficial effects on microbial infection, tumor growth, oxidative stress, and inflammation in rodent models [13][14][15]. Moreover, farnesol produced by candida albicans was previously reported to induce the expression of inflammatory cytokines in a transformed murine macrophage line [16].…”

Section: Introductionmentioning

confidence: 99%

Farnesol Inhibits PI3 Kinase Signaling and Inflammatory Gene Expression in Primary Human Renal Epithelial Cells

Müller,

Lozoya,

Chen

et al. 2023

Biomedicines

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Chronic inflammation and elevated cytokine levels are closely associated with the progression of chronic kidney disease (CKD), which is responsible for the manifestation of numerous complications and mortality. In addition to conventional CKD therapies, the possibility of using natural compounds with anti-inflammatory potential has attracted widespread attention in scientific research. This study aimed to study the potential anti-inflammatory effects of a natural oil compound, farnesol, in primary human renal proximal tubule epithelial cell (RPTEC) culture. Farnesol was encapsulated in lipid-based small unilamellar vesicles (SUVs) to overcome its insolubility in cell culture medium. The cell attachment of empty vesicles (SUVs) and farnesol-loaded vesicles (farnesol-SUVs) was examined using BODIPY, a fluorescent dye with hydrophobic properties. Next, we used multiple protein, RNA, and protein phosphorylation arrays to investigate the impact of farnesol on inflammatory signaling in RPTECs. The results indicated that farnesol inhibits TNF-α/IL-1β-induced phosphorylation of the PI3 kinase p85 subunit and subsequent transcriptional activation of the inflammatory genes TNFRSF9, CD27, TNFRSF8, DR6, FAS, IL-7, and CCL2. Therefore, farnesol may be a promising natural compound for treating CKD.

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