FAS-670A/G polymorphism: A biomarker for the metastasis of nasopharyngeal carcinoma in a Chinese population

Zhu, Qingyao; Wang, Tao; Ren, Jinghua; Hu, Kai; Liu, Wei; Wu, Gang

doi:10.1016/j.cca.2009.10.024

Cited by 14 publications

(4 citation statements)

References 31 publications

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“…The distribution of TNM staging in the present study was mostly comparable to that of a number of studies from different populations. The only exception was that the proportion of NPC cases diagnosed with T1 staging was higher in the present study compared studies done elsewhere [ 58 – 60 ].…”

Section: Discussioncontrasting

confidence: 93%

Association of hOGG1 Ser326Cys, ITGA2 C807T, TNF-A -308G>A and XPD Lys751Gln polymorphisms with the survival of Malaysian NPC patients

et al. 2018

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BackgroundNasopharyngeal carcinoma is a rare form of cancer across the world except in certain areas such as Southern China, Hong Kong and Malaysia. NPC is considered a relatively radiosensitive tumor and patients diagnosed at early stages tend to survive longer compared to those with advanced disease. Given that early symptoms of NPC are non-specific and that the nasopharynx is relatively inaccessible, less invasive screening methods such as biomarker screening might be the key to improve NPC survival and management. A number of genes with their respective polymorphisms have been shown in past studies to be associated with survival of various cancers. hOGG1 and XPD genes encode for a DNA glycosylase and a DNA helicase respectively; both are proteins that are involved in DNA repair. ITGA2 is the alpha subunit of the transmembrane receptor integrin and is mainly responsible for cell-cell and cell-extracellular matrix interaction. TNF-α is a cytokine that is released by immune cells during inflammation.MethodsRestriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) was used to genotype all the aforementioned gene polymorphisms. Kaplan-Meier survival function, log-rank test and Cox regression were used to investigate the effect of gene polymorphisms on the all-cause survival of NPC.ResultsNPC cases carrying T/T genotype of ITGA2 C807T have poorer all-cause survival compared to those with C/C genotypes, with an adjusted HR of 2.06 (95% CI = 1.14–3.72) in individual model. The 5-year survival rate of C/C carriers was 55% compared to those with C/T and T/T where the survival rates were 50% and 43%, respectively.ConclusionThe finding from the present study showed that ITGA2 C807T polymorphism could be potentially useful as a prognostic biomarker for NPC. However, the prognostic value of ITGA2 C807T polymorphism has to be validated by well-designed further studies with larger patient numbers.

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Section: Discussioncontrasting

confidence: 93%

Association of hOGG1 Ser326Cys, ITGA2 C807T, TNF-A -308G>A and XPD Lys751Gln polymorphisms with the survival of Malaysian NPC patients

et al. 2018

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“…Some studies before had shown that there was an association between Fas rs180082 and some cancers, including nasopharyngeal carcinoma [36], lung cancer [37,38], gastric cancer [39] and leukemia [40]. Otherwise, some studies draw a different conclusion [41].…”

Section: Discussionmentioning

confidence: 99%

Lack of association between Fas rs180082polymorphism and risk of cervical cancer: an update by meta-analysis

Chen

Peng

et al. 2013

BMC Med Genet

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BackgroundThe Fas rs180082 polymorphism has been reported to be associated with cervical cancer susceptibility, yet the results of these previous results have been inconsistent or controversial. The objective of this study was to explore whether the Fas rs180082 polymorphism confers susceptibility to cervical cancer.MethodsThe relevant studies were identified through a search of PubMed, Excerpta Medica Database (Embase), Elsevier Science Direct and Chinese Biomedical Literature Database (CBM) until July 2012. The association between the Fas rs180082 polymorphism and cervical cancer risk was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs).ResultsA total of 7 case–control studies were eventually identified. We found no association between Fas rs180082 polymorphism and cervical cancer susceptibility in overall population (G versus A: OR = 1.03, 95% CI = 0.99-1.07, P = 0.197; AG + GG versus AA: OR = 1.04, 95% CI = 0.98-1.09, P = 0.176; GG versus AA + AG: OR = 1.04, 95% CI = 0.84–1.31, P = 0.701). In subgroup analysis, similar results were found in Asian (G versus A: OR = 1.06, 95% CI = 0.97–1.15, P = 0.195; AG + GG versus AA: OR = 1.08, 95% CI = 0.98–1.19, P = 0.176; GG versus AA + AG: OR = 0.97, 95% CI = 0.51–1.84, P = 0.935) and African (G versus A: OR = 1.01, 95% CI = 0.97-1.15, P = 0.195; AG + GG versus AA: OR = 0.99, 95% CI = 0.91–1.07, P = 0.739; GG versus AA + AG: OR = 1.09, 95% CI = 0.94–1.25, P = 0.745).ConclusionThis meta-analysis has shown that there is a lack of association of the Fas rs180082 polymorphisms with cervical cancer susceptibility. However, larger scale primary studies with the consideration of gene–gene and gene–environment interactions are still required to further evaluate the interaction of Fas rs180082 polymorphism with cervical cancer susceptibility.

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“…In accordance with the eligibility criteria, 78 studies were excluded in the first step of duplicate screening, 164 studies were subsequently removed for title and abstract review, and 10 studies were removed because they were not case–control studies, molecular biology research, or without available data and not focused on specific loci. Eventually, 9 publications (20 independent case–control studies) involving 3179 patients and 4217 controls were selected, [ 24 , 32 – 39 ] including 7 case–control studies investigating Fas -670A>G, [ 24 , 32 , 34 , 35 , 37 – 39 ] 7 case–control studies investigating Fas -1377G>A, [ 32 , 33 , 35 – 39 ] and 6 case–control studies investigating FasL -844C>T, [ 32 , 35 – 39 ] respectively. Furthermore, 6 publications involved Asian populations, [ 34 – 39 ] and 3 studies involved Caucasian populations.…”

Section: Resultsmentioning

confidence: 99%

“…Eventually, 9 publications (20 independent case–control studies) involving 3179 patients and 4217 controls were selected, [ 24 , 32 – 39 ] including 7 case–control studies investigating Fas -670A>G, [ 24 , 32 , 34 , 35 , 37 – 39 ] 7 case–control studies investigating Fas -1377G>A, [ 32 , 33 , 35 – 39 ] and 6 case–control studies investigating FasL -844C>T, [ 32 , 35 – 39 ] respectively. Furthermore, 6 publications involved Asian populations, [ 34 – 39 ] and 3 studies involved Caucasian populations. [ 24 , 32 , 33 ] Regarding the HWE in controls, 1 case–control study deviated the HWE for the Fas -670A>G polymorphism [ 35 ] and Fas -1377G>A polymorphism, [ 37 ] and 2 case–control studies for the FasL -844C>T polymorphism.…”

Section: Resultsmentioning

confidence: 99%

Quantitative assessment of the relationship between Fas/FasL genes polymorphisms and head and neck cancer risk

Zhang¹,

Jiang

Qin

et al. 2018

Medicine

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Background:Molecular epidemiological studies have demonstrated a closer association between Fas/FasL polymorphisms and head and neck cancer (HNC) risk, and the results of these published studies were inconsistent. We therefore performed this meta-analysis to explore the associations between Fas/FasL polymorphisms and HNC risk.Methods:Four online databases (PubMed, Embase, CNKI, and Wanfang) were searched. Odds ratios (ORs) with 95% confidence interval (95% CIs) were calculated to assess the association between Fas -670A>G, Fas -1377G>A, and FasL -844C>T polymorphisms and HNC risk. In addition, heterogeneity, accumulative/sensitivity analysis, and publication bias were conducted to check the statistical power.Results:Overall, 9 related publications (20 independent case–control studies) involving 3179 patients and 4217 controls were identified. Significant association of protective effects was observed between FasL -844C>T polymorphism and HNC risk in codominant and dominant model models (CT vs CC: OR = 0.89, 95% CI = 0.79–1.00, P = .05, I2 = 38.3%, CT+TT vs CC: OR = 0.88, 95% CI = 0.79–0.98, P = .02, I2 = 35.8%). Furthermore, the similar protective effects were observed the subgroup analysis of in Asian population and population-based controls group.Conclusion:Our meta-analysis indicated that FasL -844C>T polymorphism plays a protective role against HNC development, but the Fas -670A>G and Fas -1377G>A polymorphisms maybe not associated with HNC risk.

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FAS-670A/G polymorphism: A biomarker for the metastasis of nasopharyngeal carcinoma in a Chinese population

Cited by 14 publications

References 31 publications

Association of hOGG1 Ser326Cys, ITGA2 C807T, TNF-A -308G>A and XPD Lys751Gln polymorphisms with the survival of Malaysian NPC patients

Association of hOGG1 Ser326Cys, ITGA2 C807T, TNF-A -308G>A and XPD Lys751Gln polymorphisms with the survival of Malaysian NPC patients

Lack of association between Fas rs180082polymorphism and risk of cervical cancer: an update by meta-analysis

Quantitative assessment of the relationship between Fas/FasL genes polymorphisms and head and neck cancer risk

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