FAS and ErbB2 expression in early local recurrent oral cancer

Pinto, Lucielma Salmito Soares; Aguiar, Francisco; Kowalski, Luiz Paulo; Graner, Edgard; Lopes, Márcio Ajudarte

doi:10.1111/j.1600-0714.2009.00822.x

Cited by 13 publications

(19 citation statements)

References 31 publications

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“…Higher values failed to present many of these associations. PINTO et al 23 have also reported the same value as a better cutoff point for the Anneroth system, which was also related to survival rates (OS and DFS). In the same way, the Bryne score was classified according to the median value (10) and higher values until 12 points were attained.…”

Section: [ ( ) T D $ F I G ]mentioning

confidence: 81%

“…Although biomarkers have been widely studied to better evaluate prognosis in oral cancer 8,14,16,19,23,28,33,36 , there is no routine clinical application of them. Some studies have presented controversial results regarding the same biomarkers 8,16 , compromising the universal acceptance for evaluating prognosis.…”

Section: [ ( ) T D $ F I G ]mentioning

confidence: 99%

“…Using grading systems for oral cancer analysis has numerous advantages [4][5][6]18,23,30 . Nevertheless, there are some major points that impair their routine use, including the additional time required to analyze a specimen, the lack of clinical comprehension of the results of the score and the lack of treatment protocols based on the score.…”

Section: [ ( ) T D $ F I G ]mentioning

confidence: 99%

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Clinicopathological features and proliferation markers in tongue squamous cell carcinomas

Gueiros

Coletta

Kowalski

et al. 2011

International Journal of Oral and Maxillofacial Surgery

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Section: [ ( ) T D $ F I G ]mentioning

confidence: 81%

Section: [ ( ) T D $ F I G ]mentioning

confidence: 99%

Section: [ ( ) T D $ F I G ]mentioning

confidence: 99%

See 1 more Smart Citation

Clinicopathological features and proliferation markers in tongue squamous cell carcinomas

Gueiros

Coletta

Kowalski

et al. 2011

International Journal of Oral and Maxillofacial Surgery

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“…This scenario was also observed and reported in oral dysplastic premalignant disorder (Hou et al, 1992). Thus, it was suggested as a marker for oral cancer (Li et al, 1992;Xia et al, 1997;Werkmeister et al, 1999;Fong et al, 2008) and also as a prognostic marker (Pinto et al, 2010;Stoicanescu et al, 2013) for monitoring disease progression. However, there is also evidence stating that low/absence of HER2/neu expression in oral cancer (Khan et al, 2002;Schartinger et al, 2004;Henning Hanken et al, 2014).…”

Section: Discussionmentioning

confidence: 54%

Salivary Her2/neu Levels in Differentiation of Oral Premalignant Disorders and Oral Squamous Cell Carcinomas

Varun¹,

Dineshkumar²,

Jayant³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Oral squamous cell carcinoma (OSCC) is thought to develop from precancerous dysplastic lesions through multistep processes of carcinogenesis involving activation of oncogenes and loss of tumor suppressor genes. The human epidermal growth factor receptor 2 (Her-2/neu [erbB-2]), a cell membrane glycoprotein, is a growth factor receptor that has receptor tyrosine kinase activity. Her2/neu activation plays a central role in cell proliferation and survival. It has been shown that overexpression of Her2/neu increases the rate of cell division and growth, leading to precancerous changes. The aim of the present study was to compare the serum and salivary Her2/neu levels between cases with premalignant and malignant oral lesions. Materials and Methods: Fasting blood samples and unstimulated saliva by passive drooling were collected from three groups of healthy control (n=20), premalignant disorder (PMD) (n=20) and OSCC (n=25) subjects. The HER2 extracellular domain (HER2 ECD) levels were measured using ELISA. Results: The levels of serum Her2/neu showed no significant differences between any of the groups but on the other hand salivary Her2/neu levels were found to be significantly (p<0.05) higher when compared between control (median 68.7 pg/ml, range: 21.5 -75.8) and OSCC (median 145.6 pg/ml, range: 45.1-191.1). A similar trend was observed when comparing between PMD (median 43.3, range: 22.1 -94.7) and OSCC with a statistical significance of p<0.05. Conclusions: Our study provided evidence of increased salivary Her2/neu in OSCC when compared to PMD and control which was not the case for serum levels. This suggests that probably Her2/neu is not highly amplified as in breast cancer so as to be reflected in serum. Since saliva is in local vicinity of the OSCC, even a mild increase might be mirrored. On the whole, this study proposes Her2/neu as marker for distinguishing premalignant and malignant conditions.

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“…Among those bioactive molecules are the cytokines, molecules involved at the immunomodu--lizing local tissue ASCs through environmental modulation. It means that, even if the graft of transplanted stem cells bioactive molecules that are able to accelerate the healing of injured site (Zhao et al, 2004;; Kamiya et al, 2005 Santos et al, 2008;; Pinto et al, 2009). In the mean time, the biggest advantage of iPSCs is the fact they can be originated from any cell of the body as, for example, dermal epithelial cells.…”

Section: Introductionmentioning

confidence: 99%

The current need to continue researching with embryonic stem cell

Carvalho¹,

Sene²,

Carvalho³

et al. 2013

JBRA Assisted Reproduction

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Embryonic stem cells are pluripotent and able to generate all cell types of the body, being the most promising cells to the study for regenerative medicine. Following the differentiation path, there are adult stem cells, which are on their application. On the extreme opposite of embryonic stem cells there are the induced pluripotent stem cells, originated from a somatic cell after genetic reprogramming. Induced pluripotent stem cells are a recent science discovery and may substitute the use of embryonic stem cells in future research. But with nowadays knowledge, the use of adult stem cells and induced pluripotent stem cells are limited due to high expenses and long time process demand. Moreover, the development achieved on all kinds of stem cells study are, in some part, due to the study of embryonic stem cells, what makes the study of these cell type still mandatory.Keywords: stem cells, cell differentiation, cell dedifferentiation. RESUMOCélulas-tronco embrionárias são pluripotentes e com potencial de se diferenciar em todos os tipos celulares do corpo, sendo, por isso, as células mais promissoras para pesquisa em medicina regenerativa. Seguindo o processo de diferenciação há as células-tronco adultas, que já estão cria limitações ao seu uso. No extremo oposto das células--tronco embrionárias têm-se as células-tronco pluripotentes induzidas, originadas a partir de uma célula somática após reprogramação genética. As células-tronco pluripotentes induzidas são uma recente descoberta da ciência em pesquisa celular e um dia podem substituir as células-tronco embrionárias na aplicação em pesquisa. Mas com o conhecimento atual a utilização de células-tronco pluripotentes induzidas é limitada pelos altos custos e longo processo. Além do mais, o desenvolvimento alcançado com os demais tipos de células-tronco se deve, em parte, ao estudo com células-tronco embrionárias, o que de certa forma ainda obriga a continuidade de investigação com esse tipo celular.Palavras-chave: células-tronco, diferenciação celular, desdiferenciação celular.

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FAS and ErbB2 expression in early local recurrent oral cancer

Abstract: Histopathological characteristics and the expression of FAS and ErbB2 carry prognosis importance in local recurrence and overall survival in OSCC.

Cited by 13 publications

References 31 publications

Clinicopathological features and proliferation markers in tongue squamous cell carcinomas

Clinicopathological features and proliferation markers in tongue squamous cell carcinomas

Salivary Her2/neu Levels in Differentiation of Oral Premalignant Disorders and Oral Squamous Cell Carcinomas

The current need to continue researching with embryonic stem cell

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