Fascin‑1 is associated with recurrence in solitary fibrous tumor/hemangiopericytoma

Abstract

Fascin-1, an actin-bundling protein, is associated with poor prognosis in patients with various types of human carcinoma. However, research is limited on the role of fascin-1 in sarcoma. Solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) are rare sarcomas derived from the mesenchyme. Although the prognosis of SFT/HPC is generally favorable, fatalities are possible with repeated recurrence and distant metastasis. The current study included a total of 20 Japanese patients, who were diagnosed with SFT/HPC and underwent surgery at Kochi University Hospital from January 2000 to December 2019. The statistical relationship between recurrence and the following variables were examined: Sex, age of onset, tumor origin, tumor size, necrosis, mitosis ≥1/10 high power field (HPF; magnification, x400), Ki-67 >5% and Fascin-1. A significant association was determined between recurrence and necrosis, mitosis ≥1/10 HPF (magnification, x400), Ki-67 >5%, and Fascin-1 ≥'strongly positive' (P<0.05). The results demonstrated that Fascin-1 immunostaining may be a highly effective and useful evaluation factor for predicting poor prognosis in patients with SFT/HPC, a fatal sarcoma of humans.

Evaluation of Clinical and Immunohistochemical Factors Relating to Melanoma Metastasis: Potential Roles of Nestin and Fascin in Melanoma

“…Fascin also exists in different tissues of the human body, such as mesenchyme and nervous tissue, however, it is not present in most normal epithelia. Its correlation to malignancy has also been reported in various carcinomas and sarcomas [ 23 , 24 , 25 , 26 , 27 ]. Although, unlike Nestin, there is no commonly accepted role of Fascin regarding melanoma malignancy [ 7 , 8 , 9 , 10 , 11 ].…”

“…Nestin expression is observed in various embryonic cells and tissues, and a correlation of Nestin expression to clinical malignancy has been reported in melanoma and other tumors, such as breast cancer, ovarian cancer, and osteosarcoma [ 13 , 14 , 18 , 21 , 22 ]. Fascin, an actin-bundling protein, plays an important role in the regulation of cell adhesion, migration and invasion [ 23 , 24 , 25 , 26 , 27 ]. Fascin also exists in different tissues of the human body, such as mesenchyme and nervous tissue, however, it is not present in most normal epithelia.…”

“…However, there are few studies regarding the relationship between Nestin and Fascin. The authors have also accomplished several studies on Nestin and Fascin [ 23 , 24 , 28 ], and, in this study, one of our aims was to reveal the relationship between Nestin and Fascin and the reason why there are contradicting opinions concerning Fascin expression in melanoma malignancy. As shown in Figure 7 , tumor cells with Nestin and Fascin double-positive expression were detected in the double immunofluorescence staining of Nestin and Fascin.…”

Liver Metastasis From Intracranial Hemangiopericytoma 8 Years After Initial Resection: Case Report

“…8 Immunostaining of Fascin-1, a protein involved in cell migration and invasion, has also shown great potential in predicting patient prognosis. In a study performed by Yamamoto et al, 11 Fascin-1 has a strong association with tumor recurrence ( P < .05). Metastasis of SFT/HPC can occur several years after the initial diagnosis, even after total gross resection of the tumor, with a mean time of 7.5 years.…”

Solitary fibrous tumor of the buccal mucosa: A case report

“…These results showed that SFTs occurring in the oral region have a low risk of recurrence. However, it has been reported that recurrence is more likely to occur when the Ki-67 positivity rate in SFT tumor cells exceeds 5％ 8 . In our case, although no evidence of necrosis was observed in the tumor cells, the Ki-67 positivity rate was 5％, suggesting that careful follow-up was necessary.…”