Fast &amp; fluorinated – Development and validation of a rapid benchtop NMR approach and other routine screening methods for the detection and quantification of synthesized fluorofentanyl derivatives

Gilbert, Nicolas; Mewis, Ryan E.; Sutcliffe, Oliver B.

doi:10.1016/j.forc.2021.100321

Cited by 11 publications

(5 citation statements)

References 40 publications

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“…Their work showed the ability to use IR spectroscopy alongside 1D and 2D NMR on a small subset of compounds to obtain elucidation. Other recent work has looked at the use of fluorine NMR for analysis of fluorinated drugs like synthetic cannabinoids and fluorofentanyls (Gilbert et al, 2021).…”

Section: Low-field or Benchtop Nmr Spectroscopymentioning

confidence: 99%

Forensic seized drug analysis: Current challenges and emerging analytical solutions

Sisco

2023

WIREs Forensic Science

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Over the past decade, new challenges in seized drug analysis have pushed the limits of existing instrumentation and workflows. These challenges include increasing caseloads, complex samples containing previously unidentified substances, and evolving legal requirements. Traditional approaches to seized drug analysis—such as gas chromatography mass spectrometry, color tests, and Fourier transform infrared spectroscopy—can be insufficient for current challenges, motivating the community to explore new instrumentation or data analysis solutions. However, the road to validation, implementation, and adoption of new technologies and solutions can be arduous. In this overview, we discuss the major challenges facing the seized drug community that can be addressed by advances in analytical approaches and highlight some emerging techniques that have been or could be adopted by laboratories in the near‐term. We also discuss specific hurdles limiting the implementation and adoption of new techniques, and approaches to lower these barriers.This article is categorized under: Forensic Chemistry and Trace Evidence > Controlled and Emerging Drug Compounds Forensic Chemistry and Trace Evidence > Emerging Technologies and Methods Forensic Chemistry and Trace Evidence > Presentation and Evaluation of Forensic Science Output

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Section: Low-field or Benchtop Nmr Spectroscopymentioning

confidence: 99%

Forensic seized drug analysis: Current challenges and emerging analytical solutions

Sisco

2023

WIREs Forensic Science

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“…However, as high-field NMR Studies to overcome the disadvantage of low resolution in benchtop NMR spectroscopy for drug analysis have been conducted in a manner similar to that used for food analyses. The traditional method is to use other NMR-active nuclides such as 19 F or 31 P together with 1 H [42][43][44]. In particular, as the heteronuclear NMR spectra are very simple, unlike 1 H spectra, in which overlap often occurs, they may be useful for the identification of certain molecules containing the corresponding nuclides.…”

Section: Polymer Materialsmentioning

confidence: 99%

“…19 F is a very useful nuclide for benchtop NMR spectroscopy, as its relatively high sensitivity and a resonant frequency similar to that of to 1 H allow signals to be measured in the same coil. Low-field 19 F NMR spectroscopy has been used for pharmaceutical and drug identification [43,44], reaction monitoring [121], and organic compound analysis [122,123]. 19 F NMR spectroscopy can also be used as an auxiliary method for 1 H NMR spectral analysis, especially in cases of severe signal overlap [10].…”

Section: Heteroatom Nmr Spectroscopymentioning

confidence: 99%

Recent Applications of Benchtop Nuclear Magnetic Resonance Spectroscopy

Myoung

Ahn

2021

Magnetochemistry

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Benchtop nuclear magnetic resonance (NMR) spectroscopy uses small permanent magnets to generate magnetic fields and therefore offers the advantages of operational simplicity and reasonable cost, presenting a viable alternative to high-field NMR spectroscopy. In particular, the use of benchtop NMR spectroscopy for rapid in-field analysis, e.g., for quality control or forensic science purposes, has attracted considerable attention. As benchtop NMR spectrometers are sufficiently compact to be operated in a fume hood, they can be efficiently used for real-time reaction and process monitoring. This review introduces the recent applications of benchtop NMR spectroscopy in diverse fields, including food science, pharmaceuticals, process and reaction monitoring, metabolomics, and polymer materials.

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“…Low-field (LF) benchtop NMR spectrometers have gained attention in the recent years for education, 3,4 forensic, 5,6 and environmental 7,8 sectors. Particularly, keen interest has developed in the application of these spectrometers as a reaction monitoring tool.…”

Section: Introductionmentioning

confidence: 99%

Quantitative and convenient real-time reaction monitoring using stopped-flow benchtop NMR

2022

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Fast & fluorinated – Development and validation of a rapid benchtop NMR approach and other routine screening methods for the detection and quantification of synthesized fluorofentanyl derivatives

Cited by 11 publications

References 40 publications

Forensic seized drug analysis: Current challenges and emerging analytical solutions

Forensic seized drug analysis: Current challenges and emerging analytical solutions

Recent Applications of Benchtop Nuclear Magnetic Resonance Spectroscopy

Quantitative and convenient real-time reaction monitoring using stopped-flow benchtop NMR

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