Fast and opposite temperature responsivity in release behavior of cocontinuous hydrogel composites

Kim, Soyun; Kim, Junseok; Lee, Jonghwi

doi:10.1016/j.jiec.2021.09.002

Cited by 5 publications

(2 citation statements)

References 31 publications

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“…The swelling‐shrinking transition often occurs at the UCST or LCST in temperature‐responsive hydrogels. That is, the reaction mechanism of temperature‐responsive hydrogels is mainly manifested in the phase change and size of the hydrogel (Kim et al., 2021; Y. Xu et al., 2022). Within a specific range of temperature changes, temperature‐sensitive peptide hydrogels can undergo a sol–gel transition (Drozdov & Christiansen, 2021; Yoshida, 2022).…”

Section: Properties Of Peptide Hydrogelsmentioning

confidence: 99%

Peptide hydrogels: Synthesis, properties, and applications in food science

Sheng

Huang

Shen³

et al. 2023

Comp Rev Food Sci Food Safe

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Due to the unique and excellent biological, physical, and chemical properties of peptide hydrogels, their application in the biomedical field is extremely wide. The applications of peptide hydrogels are closely related to their unique responsiveness and excellent properties. However, its defects in mechanical properties, stability, and toxicity limit its application in the food field. In this review, we focus on the fabrication methods of peptide hydrogels through the physical, chemical, and biological stimulations. In addition, the functional design of peptide hydrogels by the incorporation with materials is discussed. Meanwhile, the excellent properties of peptide hydrogels such as the stimulus responsiveness, biocompatibility, antimicrobial properties, rheology, and stability are reviewed. Finally, the application of peptide hydrogel in the food field is summarized and prospected.

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Section: Properties Of Peptide Hydrogelsmentioning

confidence: 99%

Peptide hydrogels: Synthesis, properties, and applications in food science

Sheng

Huang

Shen³

et al. 2023

Comp Rev Food Sci Food Safe

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“…However, the researchers used a relaxation process, which is not exactly directional crystallization. Lee et al used nanopores for confined crystallization of drugs, which showed only a limited degree of directionality. ,− …”

Section: Introductionmentioning

confidence: 99%

Ordered Submicrometer Structures Developed by Directional Evaporative Crystallization of Acetaminophen in the Presence of Polymers

Seo

Lee

2022

Crystal Growth & Design

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Crystallization engineering is crucial for the preparation of drug delivery systems with precise release behavior and improved stability. Although evaporation has been commonly used to prepare pharmaceutical film formulations, controlled evaporative crystallization to achieve uniform crystal size and shape has rarely been investigated. In this study, ordered submicrometer composite structures of acetaminophen (ACM) and polymers were prepared via directional evaporative crystallization controlled by a temperature gradient. The ACM crystals had submicrometer sizes while retaining the original crystal polymorph and were aligned along the direction of the temperature gradient, resulting in line structures having branches with uniform and oriented crystal structures. Although the use of a polymer did not affect conventional oven-crystallized films, it significantly decreased the melting point and heat of fusion of directionally crystallized films. The formation of ordered submicrometer composite structures must rely more on kinetic parameters than thermodynamic parameters since no significant intrinsic molecular interactions were discovered. A wide range of sustained-release characteristics could be obtained depending on the polymer types. This unique fast directional crystallization method could offer a new opportunity for future film delivery systems.

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Tailoring the Swelling‐Shrinkable Behavior of Hydrogels for Biomedical Applications

Feng

Wang

2023

Advanced Science

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Hydrogels with tailor‐made swelling‐shrinkable properties have aroused considerable interest in numerous biomedical domains. For example, as swelling is a key issue for blood and wound extrudates absorption, the transference of nutrients and metabolites, as well as drug diffusion and release, hydrogels with high swelling capacity have been widely applicated in full‐thickness skin wound healing and tissue regeneration, and drug delivery. Nevertheless, in the fields of tissue adhesives and internal soft‐tissue wound healing, and bioelectronics, non‐swelling hydrogels play very important functions owing to their stable macroscopic dimension and physical performance in physiological environment. Moreover, the negative swelling behavior (i.e., shrinkage) of hydrogels can be exploited to drive noninvasive wound closure, and achieve resolution enhancement of hydrogel scaffolds. In addition, it can help push out the entrapped drugs, thus promote drug release. However, there still has not been a general review of the constructions and biomedical applications of hydrogels from the viewpoint of swelling‐shrinkable properties. Therefore, this review summarizes the tactics employed so far in tailoring the swelling‐shrinkable properties of hydrogels and their biomedical applications. And a relatively comprehensive understanding of the current progress and future challenge of the hydrogels with different swelling‐shrinkable features is provided for potential clinical translations.

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Fast and opposite temperature responsivity in release behavior of cocontinuous hydrogel composites

Cited by 5 publications

References 31 publications

Peptide hydrogels: Synthesis, properties, and applications in food science

Peptide hydrogels: Synthesis, properties, and applications in food science

Ordered Submicrometer Structures Developed by Directional Evaporative Crystallization of Acetaminophen in the Presence of Polymers

Tailoring the Swelling‐Shrinkable Behavior of Hydrogels for Biomedical Applications

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