Fast and Slow Release: Synthesis of Gelatin Casted-Film Based Drug Delivery System

Laha, Anindita; Bhutani, Utkarsh; Mitra, Kishalay; Majumdar, Saptarshi

doi:10.1080/10426914.2015.1070422

Cited by 15 publications

(15 citation statements)

References 18 publications

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“…Pure GA showed the bands at 1662 cm −1 relative to the vibration of the amide carbonyl group; at 1543 cm −1 it was associated with stretching of the free amino groups [ 4 , 15 , 57 ]. The peak at 1243 cm −1 corresponds to CN stretching, NH in-plane bending, and CH 2 wagging vibrations [ 58 , 59 ].…”

Section: Resultsmentioning

confidence: 99%

“…The peak at 1243 cm −1 corresponds to CN stretching, NH in-plane bending, and CH 2 wagging vibrations [ 58 , 59 ]. The broad absorption band at 3320 cm −1 is assigned to the OH stretching and internal hydrogen bonds, which overlap with N−H stretching [ 57 ].…”

Section: Resultsmentioning

confidence: 99%

“…The release of the drug from the buccal film is determined by drug/polymer properties. It also depends on the drug solubility, the drug diffusion from the film, the swelling, and degradation of the polymer matrix [ 42 , 57 , 86 , 87 ]. Although propranolol hydrochloride solubility is not expected to be the rate-limiting step for its dissolution and absorption [ 52 ], a dissolution study was performed under pH conditions that correspond to the physiological pH in the oral cavity (pH of the deionized water was 6.8).…”

Section: Resultsmentioning

confidence: 99%

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Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties

et al. 2021

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This study processes and characterizes propranolol hydrochloride/gelatin mucoadhesive buccal films. Two types of gelatin are used: Gelatin from porcine skin, type A (GA), and gelatin from bovine skin (GB). The influence of gelatin type on mechanical, mucoadhesive, and biopharmaceutical characteristics of buccal films is evaluated. Fourier-Transfer infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) analysis show that GA with propranolol hydrochloride (PRH) in the film (GAP) formed a physical mixture, whereas GB with PRH (GBP) form a compound-complex. Results of mechanical testing (tensile test, hardness) revealed that GAP films exhibit higher elastic modulus, tensile strength, and hardness. A mucoahesion test shows that GBP has higher adhesion strength, while GAP shows higher work of adhesion. Both in vitro release study and in silico simulation indicated that processed films can provide effective drug transport through the buccal mucosa. In silico simulation shows improved bioavailability from buccal films, in comparison to the immediate-release tablets—indicating that the therapeutic drug dose can be markedly reduced.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties

et al. 2021

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“…In recent years, CS and GE were generally selected as primary components of wound dressings . Being one of the most abundant natural polysaccharides, CS promotes tissue growth and wound healing .…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization, antibacterial properties, and hemostatic evaluation of ibuprofen‐loaded chitosan/gelatin composite films

Cheng

Shu-zhen

et al. 2017

J of Applied Polymer Sci

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Ibuprofen-loaded chitosan/gelatin (CS/GE) composite films were fabricated in this work. The morphology of the composite film was investigated using scanning electron microscopy. The functional groups of the composite film before and after crosslinking were characterized using Fourier transform infrared spectroscopy. Meanwhile, the mechanical properties, antibacterial performance, cytocompatibility, and hemostatic activity of the composite films were investigated. The results show that the amount of CS affected the mechanical properties and liquid uptake capacities of the composite films. The composite film showed better bactericidal activity against Staphylococcus aureus than Escherichia coli. In vitro drug-release evaluations showed that crosslinking could control the drug-release rate and period in wound healing. Both types of CS/GE and drug-loaded CS/GE composite films also showed excellent cytocompatibility in cytotoxicity assays. The hemostatic evaluation indicated that the composite film crosslinked by glutaraldehyde in rabbit livers had a dramatic hemostatic efficacy. Therefore, ibuprofen-loaded CS/GE composite films are potentially applicable as a wound dressing material.

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“…Polymer based DDS has received considerable attention because of its therapeutic efficacy and lower side effect. Researcher has fused polymer science and technologies in order to develop different DDS for biomedical and pharmaceutical applications [2][3][4][5][6]. One such development is in the area of using polymeric nanofiber as DDS due to their large surface area and porosity [7][8].…”

Section: Introductionmentioning

confidence: 99%

Controlled Drug Release Formulation by Sequential Crosslinking of Multilayered Electrospun Gelatin Nanofiber Mat

2016

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The major aim of the present study is to develop and explore the potential of large surface area electrospun polymer nanofabric as a carrier for controlled and sustained release, in particular for hydrophobic drugs. Gelatin (type A), FDA approved natural polymer was electrospun in a mixture of solvent (20% acetic acid in water) to yield long, continuous and uniform fibers with average diameter ∼ 200 nm. Piperine was chosen as a model hydrophobic drug in this study. As gelatin is highly soluble in aqueous medium, we crosslinked electrospun gelatin nanofibers using saturated GTA vapor to increase the water resistive properties. For controlled release over a period of 12 h, we devised several strategies to vary the crosslinking conditions and accordingly understand their effect on drug release mechanism. One of such successful efforts was based on deposition of multiple layers of electrospun fabric by sandwiching between drug loaded gelatin nanofibers and without drug gelatin nanofibers from both sides. Not only the layer by layer deposition, we also crosslinked the different layer in the same sequential way. Sequential crosslinking using GTA vapor in different layers of the fabric, helped in uniform crosslinking throughout the thickness compared to crosslinking after final deposition in the form of a single layer. Effect of different crosslinking strategies was investigated in terms of surface morphology and drug stability. Finally,in-vitrorelease study was performed maintaining the physiological conditions mimicking GI tract to analyze the effect of crosslinking on the drug release profile. Thein-vitrostudies concluded that the controlled drug release can be achieved by tuning the thickness of individual fabric layer followed by their sequential crosslinking, which finally affects the diffusional barrier for drug release. Interestingly, we also found that only 6 min exposure to saturated GTA vapor is sufficient to provide the required drug release in contrast to up to 24 h as reported in literature. This finding also addresses the toxicity problem associated with the use of GTA as a cross-linker.

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Fast and Slow Release: Synthesis of Gelatin Casted-Film Based Drug Delivery System

Cited by 15 publications

References 18 publications

Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties

Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties

Preparation, characterization, antibacterial properties, and hemostatic evaluation of ibuprofen‐loaded chitosan/gelatin composite films

Controlled Drug Release Formulation by Sequential Crosslinking of Multilayered Electrospun Gelatin Nanofiber Mat

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