Fast Curing Multifunctional Tissue Adhesives of Sericin-Based Polyurethane-Acrylates for Sternal Closure

Abstract

The use of wire cerclage after sternal closure is the standard method because of its rigidity and strength. Despite this, they have many disadvantages such as tissue trauma, operator-induced failures, and the risk of infection. To avoid complications during sternotomy and promote tissue regeneration, tissue adhesives should be used in post-surgical treatment. Here, we report a highly biocompatible, biomimetic, biodegradable, antibacterial, and UV-curable polyurethane-acrylate (PU-A) tissue adhesive for sternal closure as a supportive to wire cerclage. In the study, PU-As were synthesized with variable biocompatible monomers, such as silk sericin, polyethylene glycol, dopamine, and an aliphatic isocyanate 4,4′-methylenebis­(cyclohexyl isocyanate). The highest adhesion strength was found to be 4322 kPa, and the ex vivo compressive test result was determined as 715 kPa. The adhesive was determined to be highly biocompatible (on L-929 cells), biodegradable, and antibacterial (on Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus bacteria). Finally, after opening the sternum of rats, the adhesive was applied to bond the bones and cured with UV for 5 min. According to the results, there was no visible inflammation in the adhesive groups, while some animals had high inflammation in the cyanoacrylate and wire cerclage groups. These results indicate that the adhesive may be suitable for sternal fixation by preventing the disadvantages of the steel wires and promoting tissue healing.

Degradable Nanohydroxyapatite-Reinforced Superglue for Rapid Bone Fixation and Promoted Osteogenesis

“…2 For instance, median sternotomy, commonly used in cardiothoracic surgery, often involves wire cerclage for post-treatment. 40 However, sternal displacement frequently occurs and leads to serious complications, such as sternal fracture and nonunion. Our results show that O-BDSG can effectively seal the sternum in an ex vivo sternal model (Figure 3G).…”

“…The most important property for orthopedic clinical use of bone adhesives is their adequate adhesion strength to fractured bone fragments . For instance, median sternotomy, commonly used in cardiothoracic surgery, often involves wire cerclage for post-treatment . However, sternal displacement frequently occurs and leads to serious complications, such as sternal fracture and nonunion.…”

Waste to Wealth: Exploring the Versatile Prospects of Discarded Silk Sericin

“…The adhesive potential of sericin also makes it suitable for a range of other applications including wound healing and hemostasis. Sevgi et al 213 devised sericin-based polyurethane-acrylates tissue adhesives for sternal closure to prevent problems during sternotomy and encourage tissue regeneration. The glue was used to bind the bones after the sternums of the rats were opened.…”

Bioadhesives with Antimicrobial Properties

“…[ 43 ] Sometimes bioadhesives fail due to a cohesive failure instead of insufficient adhesion. [ 44 ] Therefore, bioadhesives can only function when their adhesion and cohesion characteristics meet the requirements of target application. In the following sections, chemistry of the adhesion process with regard to cohesive properties of bioadhesives will be discussed.…”