Fast environment-friendly ball mill-assisted deep eutectic solvent-based extraction of natural products

Wang, Man; Wang, Jiaqin; Zhang, Yue; Xia, Qiang; Bi, Wentao; Yang, Xiaodi; Chen, David D. Y.

doi:10.1016/j.chroma.2016.03.061

Cited by 91 publications

(37 citation statements)

References 30 publications

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“…With these characteristics, DESs have been widely utilized in many fields,33, 34, 35, 36, 37 such as metal processing33 and synthesis media or templates 34, 35. DESs also have effects on delignification and can be used in the extraction of bioactives38, 39 and biomass refinery 40, 41, 42, 43, 44, 45, 46, 47. Francisco et al.…”

Section: Introductionmentioning

confidence: 99%

“…With these characteristics, DESs have been widely utilized in many fields, [33][34][35][36][37] such as metal processing [33] and synthesis media or templates. [34,35] DESs also have effects on delignification and can be used in the extraction of bioactives [38,39] and biomass refinery. [40][41][42][43][44][45][46][47] Francisco et al reported that aD ES was promising for wheat straw processing because lignin was partially dissolved.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Efficient Cleavage of Lignin–Carbohydrate Complexes and Ultrafast Extraction of Lignin Oligomers from Wood Biomass by Microwave‐Assisted Treatment with Deep Eutectic Solvent

et al. 2017

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Lignocellulosic biomass is an abundant and renewable resource for the production of biobased value‐added fuels, chemicals, and materials, but its effective exploitation by an energy‐efficient and environmentally friendly strategy remains a challenge. Herein, a facile approach for efficiently cleaving lignin–carbohydrate complexes and ultrafast fractionation of components from wood by microwave‐assisted treatment with deep eutectic solvent is reported. The solvent was composed of sustainable choline chloride and oxalic acid dihydrate, and showed a hydrogen‐bond acidity of 1.31. Efficient fractionation of lignocellulose with the solvent was realized by heating at 80 °C under 800 W microwave irradiation for 3 min. The extracted lignin showed a low molecular weight of 913, a low polydispersity of 1.25, and consisted of lignin oligomers with high purity (ca. 96 %), and thus shows potential in downstream production of aromatic chemicals. The other dissolved matter mainly comprised glucose, xylose, and hydroxymethylfurfural. The undissolved material was cellulose with crystal I structure and a crystallinity of approximately 75 %, which can be used for fabricating nanocellulose. Therefore, this work promotes an ultrafast lignin‐first biorefinery approach while simultaneously keeping the undissolved cellulose available for further utilization. This work is expected to contribute to improving the economics of overall biorefining of lignocellulosic biomass.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficient Cleavage of Lignin–Carbohydrate Complexes and Ultrafast Extraction of Lignin Oligomers from Wood Biomass by Microwave‐Assisted Treatment with Deep Eutectic Solvent

et al. 2017

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“…Wang et al. used a ball mill‐assisted DES‐based extraction method to extract cryptotanshinone, tanshinones I, and tanshinone II from Salvia miltiorrhiza Bunge . Bakirtzi et al.…”

Section: Application Of Deep Eutectic Solvents In Separation and Extrmentioning

confidence: 99%

Development of deep eutectic solvents applied in extraction and separation

Row

2016

J of Separation Science

380

158

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Deep eutectic solvents, as an alternative to ionic liquids, have greener credentials than ionic liquids, and have attracted considerable attention in related chemical research. Deep eutectic solvents have attracted increasing attention in chemistry for the extraction and separation of various target compounds from natural products. This review highlights the preparation of deep eutectic solvents, unique properties of deep eutectic solvents, and synthesis of deep-eutectic-solvent-based materials. On the other hand, application in the extraction and separation of deep eutectic solvents is also included in this report. In this paper, the available data and references in this field are reviewed to summarize the applications and developments of deep eutectic solvents. Based on the development of deep eutectic solvents, an exploitation of new deep eutectic solvents and deep eutectic solvents-based materials is expected to diversify into extraction and separation.

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“…[6][7][8][9][10][11][12] Currently, DESs, as another emerging solvent replacing traditional organic solvents, are being used to extract bioactive compounds, such as flavonoids, phenolic acids, polyphenols, tanshinones, rosiglitazones, saponins, and anthraquinones from various types of natural sources. [13][14][15][16][17][18][19] The conventional extraction solvents, such as methanol, ethyl acetate, ethanol and so on, are hazardous and flammable, and there is inadequate disposal for the solvents, while DESs can solve these problems effectively.…”

mentioning

confidence: 99%

Deep eutectic solvent as a green solvent for enhanced extraction of narirutin, naringin, hesperidin and neohesperidin from Aurantii Fructus

Liu

Zhang

et al. 2018

Phytochemical Analysis

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Introduction In the present study, a green and efficient extraction method using deep eutectic solvents as extraction solvent was developed for extracting the four major active compounds narirutin, naringin, hesperidin and neohesperidin from Aurantii Fructus. Methodology A series of tunable deep eutectic solvents were prepared and investigated by mixing choline chloride or betaine to different hydrogen‐bond donors, and betaine/ethanediol was found to be the most suitable extraction solvent. To achieve the best extraction yield, the primary factors affecting the extraction efficiency, such as hydrogen‐bond acceptor/hydrogen‐bond donor ratio, water content in deep eutectic solvents, extraction temperature, solid/liquid ratio and extraction time, were investigated. Results The optimal extraction conditions were 40% of water in betaine/ethanediol (1:4) at 60°C for heated extraction of 30 min and solid/liquid ratio 1:100 g/mL. Under the optimum extraction condition, the extraction yields of narirutin, naringin, hesperidin, and neohesperidin were 8.39 ± 0.61, 83.98 ± 1.92, 3.03 ± 0.35 and 35.94 ± 0.63 mg/g, respectively, which were much higher than those of methanol as extraction solvent (5.5 ± 0.48, 64.23 ± 1.51, 2.16 ± 0.15 and 30.14 ± 0.62 mg/g). Conclusion The present results showed that deep eutectic solvents could be promising green and efficient solvents for extraction of the bioactive ingredients from traditional Chinese medicine.

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Fast environment-friendly ball mill-assisted deep eutectic solvent-based extraction of natural products

Cited by 91 publications

References 30 publications

Efficient Cleavage of Lignin–Carbohydrate Complexes and Ultrafast Extraction of Lignin Oligomers from Wood Biomass by Microwave‐Assisted Treatment with Deep Eutectic Solvent

Efficient Cleavage of Lignin–Carbohydrate Complexes and Ultrafast Extraction of Lignin Oligomers from Wood Biomass by Microwave‐Assisted Treatment with Deep Eutectic Solvent

Development of deep eutectic solvents applied in extraction and separation

Deep eutectic solvent as a green solvent for enhanced extraction of narirutin, naringin, hesperidin and neohesperidin from Aurantii Fructus

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