Fast left prefrontal rTMS acutely suppresses analgesic effects of perceived controllability on the emotional component of pain experience

Borckardt, Jeffrey J.; Reeves, Scott; Frohman, Heather; Madan, Alok; Jensen, Mark P.; Patterson, David R.; Barth, Kelly S.; Smith, Anthony; Gracely, Richard H.; George, Mark S.

doi:10.1016/j.pain.2010.10.018

Cited by 38 publications

(53 citation statements)

References 57 publications

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“…There was some indication of increased coupling between the dorsal ACC and insula and/or SI for the uncontrollable warm condition. Although this indicates that the role of the mPFC in the context of stimulus uncontrollability might not be specific to pain, it should be noted that the dorsal ACC does not belong to the mPFC regions previously implicated in pain facilitation by negative emotions (Ploghaus et al, 2001;Schweinhardt et al, 2008;Berna et al, 2010). Consistent with this, we observed behavioral conse- Figure 5.…”

Section: Discussionsupporting

confidence: 85%

“…Because of the yoked design, uncontrollable trials had to be preceded by controllable trials (see below). In the controllable task, subjects performed a temperature regulation task (Kleinböhl et al, 1999;Hölzl et al, 2005;Becker et al, 2011). After the thermode had reached the target temperature, the subject had to keep his/her sensation constant by antagonizing any perceived temperature change using a response unit.…”

Section: Experimental Designmentioning

confidence: 99%

“…Third-level analyses were performed using a mixed-effects model implemented in FLAME (Beckmann et al, 2003). Statistical inference was based on a voxel-based threshold of Z ϭ 2.3 cluster corrected across the whole brain at p Ͻ 0.05.…”

Section: Statistical Analysis Of Fmri Datamentioning

confidence: 99%

“…Candidate regions for such a facilitation are the pain-modulatory regions medial PFC (mPFC), amygdala, and PAG, which show increased activation when pain is uncontrollable (Salomons et al, 2004;Mohr et al, 2005;Wiech et al, 2006). The mPFC, including the cingulofrontal cortex, is a pain-modulatory area that has been shown to facilitate pain in different contexts (Ploghaus et al, 2001;Mayer et al, 2005;Schweinhardt et al, 2008;Berna et al, 2010). The PAG plays an important role in descending pain-modulatory pathways, including facilitation (Porreca et al, 2002;Gwilym et al, 2009;Yoshida et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Different Brain Circuitries Mediating Controllable and Uncontrollable Pain

et al. 2016

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Uncontrollable, compared with controllable, painful stimulation can lead to increased pain perception and activation in pain-processing brain regions, but it is currently unknown which brain areas mediate this effect. When pain is controllable, the lateral prefrontal cortex (PFC) seems to inhibit pain processing, although it is unclear how this is achieved. Using fMRI in healthy volunteers, we examined brain activation during controllable and uncontrollable stimulation to answer these questions. In the controllable task, participants selfadjusted temperatures applied to their hand of pain or warm intensities to provoke a constant sensation. In the uncontrollable task, the temperature time courses of the controllable task were replayed (yoked control) and participants rated their sensation continuously. During controllable pain trials, participants significantly downregulated the temperature to keep their sensation constant. Despite receiving the identical nociceptive input, intensity ratings increased during the uncontrollable pain trials. This additional sensitization was mirrored in increased activation of pain-processing regions such as insula, anterior cingulate cortex, and thalamus. Further, increased connectivity between the anterior insula and medial PFC (mPFC) in the uncontrollable and increased negative connectivity between dorsolateral PFC (dlPFC) and insula in the controllable task were observed. This suggests a pain-facilitating role of the mPFC during uncontrollable pain and a pain-inhibiting role of the dlPFC during controllable pain, both exerting their respective effects via the anterior insula. These results elucidate neural mechanisms of context-dependent pain modulation and their relation to subjective perception.

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Section: Discussionsupporting

confidence: 85%

Section: Experimental Designmentioning

confidence: 99%

Section: Statistical Analysis Of Fmri Datamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Different Brain Circuitries Mediating Controllable and Uncontrollable Pain

et al. 2016

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“…pain intensity, whereas focusing attention on painful events appears to be related to a lowered pain perception threshold (14).…”

Section: Discussionmentioning

confidence: 96%

Depressive Attribution Style and Stressor Uncontrollability Increase Perceived Pain Intensity after Electrical Skin Stimuli in Healthy Young Men

Müller

2013

Pain Research and Management

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Many patients with major depression report painful physical complaints (1). In addition, a large proportion of patients with chronic pain suffer from depression. Fibromyalgia is a disorder sharing common features of both depression and pain disorders (2,3). Recent studies have shown that higher perceived pain intensities and negative pain-related cognitions were associated with depression in chronic pain patients (4) and with lower quality of life in patients with major depression and pain complaints (5). However, it remains unclear whether specific depression-related cognitive schemata and states predispose to intensified pain perception and the development of chronic pain, or whether acute and chronic pain may worsen or even cause depression. The great impact of persistent painful states and pain treatment on depressive symptoms and related cognitions has been demonstrated (6). Accordingly, situational dysfunctional cognitions have been linked to lower thresholds and higher intensity ratings after experimentally induced pain, whereas dispositional measurements have not (7). The predictive properties of cognitive schemata associated with depression as risk factors for the development of painful states have, thus, been questioned.Basic research has revealed specific cognitive and emotionalaffective components of neurobiological pain processing (8-10), which likely contribute to the clinically relevant overlap between depressive and pain disorders. Specifically, uncontrollability and unpredictability of painful stressors have been demonstrated to be extremely important modifiers of pain perception (11-13). Unpleasantness and helplessness of potentially painful stimuli appear to be associated with increased BackgRounD: Depressive and pain symptoms often occur concurrently in patients with psychiatric disorders or somatic diseases, but the contribution of pre-existing dysfunctional cognitive schemata to pain perception remains unclear. oBJective: To investigate the relationship between depression-related attribution styles and perceived pain intensity (PPI) after controllable versus uncontrollable electrical skin stimulation in healthy male individuals. MethoDs: Causal attributions for negative events were measured using the attribution style questionnaire (ASQ) on the dimensions internal versus external (INT), global versus specific (GLO) and stable versus unstable (STA) in 50 men (20 to 31 years of age). Additionally, symptoms of anxiety and depression (measured using the Depression Scale) as well as baseline helplessness were assessed. Participants were randomly assigned to receive self-administered (controllable) or experimenter-administered (uncontrollable) painful skin stimuli. PPI was assessed after stress exposure using a visual analogue scale (0 to 100). Relationships between PPI and depression-related cognitions were calculated using correlation and multiple regression analyses. Results: Correlation analyses revealed a moderate correlation between PPI and ASQ-INT scores (r=0.46). Following uncontrollable ...

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Perception of repeated pain relief with controllable and uncontrollable pain

Becker

Schakib‐Ekbatan

Wroblewski

et al. 2021

European Journal of Pain

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Significance statement: When in pain, pain relief can become an all-dominate goal. The perception of such pain relief can vary depending on external and internal characteristics and thus modulate, for example, requests for pain killers in clinical settings. Here, we show that perceived intensity and pleasantness of pain relief changes with repetitions and whether the preceding pain is perceived as uncontrollable. Such mechanistic knowledge needs to be considered to maximize the effects of pain relief as a rewarding and reinforcing stimulus.

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Fast left prefrontal rTMS acutely suppresses analgesic effects of perceived controllability on the emotional component of pain experience

Cited by 38 publications

References 57 publications

Different Brain Circuitries Mediating Controllable and Uncontrollable Pain

Different Brain Circuitries Mediating Controllable and Uncontrollable Pain

Depressive Attribution Style and Stressor Uncontrollability Increase Perceived Pain Intensity after Electrical Skin Stimuli in Healthy Young Men

Perception of repeated pain relief with controllable and uncontrollable pain

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