Fast magnetic resonance diffusion‐weighted imaging of acute human stroke

Abstract

Rapid MRI of the molecular diffusion of water demonstrated cerebral infarcts in 32 patients. We studied these patients at various times following the onset of ischemic symptoms and found that diffusion-weighted imaging revealed the infarcts sooner than conventional T2-weighted spin-echo imaging did; four hyperacute infarcts were shown only by diffusion-weighted imaging. Acute infarcts had lower apparent diffusion coefficients (ADCs) than noninfarcted regions did. This relative difference in ADC reached a nadir in the first 24 hours and rose progressively thereafter. Chronic infarcts showed a relative increase in diffusion and were readily distinguishable from acute infarcts. The technique takes less than 2 minutes to apply using a standard 1.5-tesla scanner in the clinical setting. Diffusion-weighted imaging has the potential to play a role in improving the early anatomic diagnosis of stroke and therefore in the development and implementation of early stroke interventions.

The magnetic resonance revolution in brain imaging: impact on neonatal intensive care

“…So far, diffusion weighted imaging has not been proven to be effective as a prognostic tool in NE. 14 This is surprising, as diffusion weighted imaging in the adult brain 15 and experimental models 16 of stroke has revolutionised the possibility of early diagnosis and intervention, often revealing image abnormalities on water diffusion maps well before CT or conventional MR. 31 P and 1 H MR spectroscopy (giving quantitative information on brain energetics, intracellular pH (pH i ) and lactate) can give early prognostic information on brain injury severity. However, for logistical reasons it is almost impossible to transport sick infants with NE to an MR system and perform an MR study within six hours of birth.…”

An echo-shifted gradient-echo MRI method for efficient diffusion weighting

“…For example, DW-MRI allows the detection of cerebral ischemia at a very early stage (1,2). Following studies on animal models of stroke (1-10), DW-MRI has been successfully applied in the clinic (11)(12)(13)(14)(15). Nevertheless, in vivo DW-MRI remains technically challenging because of motion problems, since DW-MRI methods are typically sensitized to diffusion displacements of only a few micrometers.…”

The Role of Diffusion Weighted MR for Differentiation Between Benign and Malign Pancreatic Masses

“…[3][4][5] EPI gibi hızlı MRG sekanslarının geliştirilmesi ile diğer vücut bölümlerinde de uygulama alanı bulunmuştur. İlk olarak 1994 yılında Müller ve ark.…”