Fast neutron radiotherapy for primary mucosal melanomas of the head and neck

Liao, Jay J.; Parvathaneni, Upendra; Laramore, George E.; Thompson, John A.; Bhatia, Shailender; Futran, Neal D.; Bhrany, Amit D.; Hawes, Stephen E.; Ladra, Matthew M.

doi:10.1002/hed.23428

Cited by 23 publications

(28 citation statements)

References 33 publications

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“…This classification, missing T1 and T2 stages, can be attributed to the aggressive local growth pattern of this tumor entity with irregular borders, melanosis, and in-transit metastases [9]. conventional chemotherapies have not so far shown any significant benefit [10][11][12].…”

Section: Introductionmentioning

confidence: 97%

Identification and clinical relevance of PD-L1 expression in primary mucosal malignant melanoma of the head and neck

Thierauf¹,

Veit²,

Affolter

et al. 2015

Melanoma Research

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Mucosal melanoma of the head and neck is a rare and aggressive tumor entity with a poor prognosis. The standard treatment is radical tumor resection, with or without adjuvant radiation, where conventional chemotherapies in advanced stage or recurrent diseases have shown little benefit. Overexpression of the programmed cell death ligand 1 (PD-L1) is a common feature in human cancer. Although PD-L1 is an acknowledged prognostic biomarker for dismal prognosis in other tumors of the head and neck, expression and clinical relevance of PD-L1 in mucosal melanoma have not been addressed so far. We assessed PD-L1 expression using immunohistochemical staining in 23 tumor samples from patients with primary mucosal melanoma and correlated expression status with clinicopathological and outcome data. Tumors were derived from the nasal cavity (43.5%), nasal sinuses (43.5%), and the conjunctiva (13%). All patients had undergone surgery; 39% of all patients received adjuvant radiation and 13% were administered systemic interferon therapy. The probability of 1- and 5-year overall survival was 87 and 34.8%, respectively. The mean overall survival was 51 months and the mean recurrence-free survival was 23 months. Immunohistochemical staining showed PD-L1 expression in 13% (3/23) of mucosal melanoma. In contrast, prominent PD-L1 staining was detected in 100% of tissue sections from a control group of cutaneous melanoma (n=9). PD-L1 expression in mucosal melanoma was not correlated with age, sex, nor anatomical localization of the tumor. Interestingly, patients with PD-L1-positive mucosal melanoma had a significantly longer recurrence-free survival (P=0.026). In contrast to cutaneous melanoma and some other malignancies, a relevant PD-L1 overexpression in mucosal melanoma could not be confirmed.

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Section: Introductionmentioning

confidence: 97%

Identification and clinical relevance of PD-L1 expression in primary mucosal malignant melanoma of the head and neck

Thierauf¹,

Veit²,

Affolter

et al. 2015

Melanoma Research

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“…[7] Conventional radiotherapy as a primary modality of treatment has been shown to achieve a 5-year local control rate of 13%, while postoperative radiotherapy achieves a rate of 30%. [20] Liao JJ et al studied the effects of fast neutron radiotherapy on primary mucosal melanoma and found an overall local control rate of 79%. [20] Other modalities of radiotherapy like intensity modulated radiotherapy, proton therapy and carbon ion therapy have shown promising results in clinical trials.…”

Section: Discussionmentioning

confidence: 99%

“…[20] Liao JJ et al studied the effects of fast neutron radiotherapy on primary mucosal melanoma and found an overall local control rate of 79%. [20] Other modalities of radiotherapy like intensity modulated radiotherapy, proton therapy and carbon ion therapy have shown promising results in clinical trials. [7] Further validation with a large sample size is required to assess the effectiveness of these modalities.…”

Section: Discussionmentioning

confidence: 99%

Sinonasal Mucosal Melanoma: A Clinicopathological Review

Das¹,

Mukherjee²

2016

jemds

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Melanomas are malignant tumours, which originate from melanocytes. Melanocytes originate from the neural crest cells and then migrate to various tissues in the body during the course of development. Sinonasal melanoma are rare tumours and the aetiopathogenesis, treatment and staging of the tumours are still an area of debate. There remains paucity of studies dealing exclusively with sinonasal melanoma. We attempt to make a comprehensive study of the disease by reviewing the existing literature on sinonasal melanoma. METHODOLOGYReview of existing literature on the melanoma of nose and paranasal sinus. RESULTS AND DISCUSSIONThe melanoma of the sinonasal tract are rare and account for 1% of all melanoma. The aetiology of the tumour is still debated and the behaviour of the tumour remains conspicuously different both genetically and clinically from its cutaneous counterpart. Surgery remains the mainstay of treatment, though newer modalities are being explored. The prognosis of these tumours remain grim with a 5-year survival rate of about 25%. CONCLUSIONEarly diagnosis, histopathological confirmation and aggressive control of the primary tumour is the standard modality of treatment. The molecular biology and genetics of the tumour are an interesting field of research and targeted therapy may hold the key to improve the outcome in the future.

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“…Por otro lado recientes estudios indican igual efectividad a nivel de control local del uso de altas dosis de radioterapia fraccionada en comparación con la cirugía curativa; en nuestro caso se decide radioquimioterapia para lograr control local y a distancia, coincidiendo con la literatura consultada 10,11 . Recientemente altas tasas de control locorregional se logra según algunos estudios con radioterapia de neutrones rápidos, con una tasa de supervivencia a 5 años de 66% según Liao y cols 12,13 . El pronóstico de esta enfermedad es sombrío y depende de múltiples factores, en una revisión retrospectiva de 65 pacientes entre 1976 y 2005 realizada por Sun y cols, se encontró diferencias en los tratados con cirugía o no, y en los tratados o no con bioterapia, presentando mejores tasas de supervivencia los que se operaron y aún mayor, los que realizaron bioterapia.…”

Section: Discussionunclassified

Tumoración endonasal y fractura de cadera derecha como cuadro clínico de un caso de melanoma mucoso nasosinusal

et al. 2015

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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Fast neutron radiotherapy for primary mucosal melanomas of the head and neck

Abstract: High rates of locoregional control were achieved with neutrons, despite the presence of gross disease. Survival was limited by early distant metastases.

Cited by 23 publications

References 33 publications

Identification and clinical relevance of PD-L1 expression in primary mucosal malignant melanoma of the head and neck

Identification and clinical relevance of PD-L1 expression in primary mucosal malignant melanoma of the head and neck

Sinonasal Mucosal Melanoma: A Clinicopathological Review

Tumoración endonasal y fractura de cadera derecha como cuadro clínico de un caso de melanoma mucoso nasosinusal

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