Fast neutrons compared with megavoltage X-rays in the treatment of patients with supratentorial glioblastoma: A controlled pilot study

Design of a boron neutron capture enhanced fast neutron therapy assembly

“…The lead collimator has an outer dimension of 20x20x10 cm 3 and an inner dimension of 5x5x10 cm 3 . It was divided into 5 layers along the neutron beam direction.…”

“…However, the use of postoperative radiotherapy has shown to increase the median survival rate [2]. Studies reported by Catterall et al has shown that the anti-tumor effects for patients receiving fast neutron therapy are greater than for patients receiving megavoltage x-ray photon therapy [3].…”

Enhancement of Fast Neutron Beams with Boron Neutron Capture Therapy: A mechanism for achieving a selective, concomitant tumor boost

“…Fast neutron radiotherapy has been extensively studied in human trials with clear advantages demonstrated over conventional photon radiation for certain neoplasms, but only equivalent results in the majority of tumors (2)(3)(4)(5)(6)(7). BNCT has yet to develop 308 T. A. RUCHHOLZ ET AL into a clinically useful tool.…”

Radioresponse and Prognosis of Malignant Glioma.

“…The prognosis of malignant glioma is extremely poor, while various new approaches have been attempted (Catteral et al 1980;Maruyama et al 1982;Chang et al 1983;Matsutani et al 1984; Nelson et al 1986; Keim et al 1987; Deutsch et al 1989;Hercbergs et al 1989; Laramore et al 1989; Shapiro et al 1989; Goodman et al 1990; Greiner et al 1990; Brady et al 1992). Although the efficacy of radiotherapy for malignant glioma is proved by the improvement of survival rates (Sheline 1977;Walker et al 1978), tumor regression can be hardly seen.…”