FastField: An open-source toolbox for efficient approximation of deep brain stimulation electric fields

Baniasadi, Mehri; Proverbio, Daniele; Gonçalves, Jorge; Hutter, Frank; Husch, Andreas

doi:10.1016/j.neuroimage.2020.117330

Cited by 39 publications

(25 citation statements)

References 41 publications

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“…For each lead, we calculated binarized stimulation volumes (or volumes of tissue activated, VTA) using the FastField algorithm as implemented in Lead-DBS with an electric-field threshold of 0.2 V/ mm and an isotropic conductivity of 0.1 S/m. 24,25 VTAs were calculated for each electrode on each lead with amplitudes ranging from 1 to 5 mA in 1 mA steps and a pulse width of 60 μsec. This resulted in 5 VTAs per electrode, 20 VTAs per lead, and 4000 VTAs over all 100 patients.…”

Section: Stimulation Volumesmentioning

confidence: 99%

Sweetspot Mapping in Deep Brain Stimulation: Strengths and Limitations of Current Approaches

Dembek

Baldermann

Petry‐Schmelzer

et al. 2022

Neuromodulation: Technology at the Neural Interface

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Section: Stimulation Volumesmentioning

confidence: 99%

Sweetspot Mapping in Deep Brain Stimulation: Strengths and Limitations of Current Approaches

Dembek

Baldermann

Petry‐Schmelzer

et al. 2022

Neuromodulation: Technology at the Neural Interface

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“…Finally, to determine anatomically accurate positioning of the directional electrodes, we used the sequential DiODe-algorithm to correct the lead orientation 30 . Stimulation volumes were estimated using the FastField approach as implemented in Lead-DBS 31 . For that purpose, each patient's volume of tissue activated (VTA) was calculated in the patient's native space and then transformed into MNI space based on the individual nonlinear normalisation.…”

Section: Imaging Electrode Reconstruction and Stimulation Modellingmentioning

confidence: 99%

Structural Connectivity of Subthalamic Nucleus Stimulation for Improving Freezing of Gait

Strelow

Baldermann

Dembek

et al. 2022

JPD

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Background: Freezing of gait (FOG) is among the most common and disabling symptoms of Parkinson’s disease (PD). Studies show that deep brain stimulation (DBS) of the subthalamic nucleus (STN) can reduce FOG severity. However, there is uncertainty about pathways that need to be modulated to improve FOG. Objective: To investigate whether STN-DBS effectively reduces FOG postoperatively and whether structural connectivity of the stimulated tissue explains variance of outcomes. Methods: We investigated 47 patients with PD and preoperative FOG. Freezing prevalence and severity was primarily assessed using the Freezing of Gait Questionnaire (FOG-Q). In a subset of 18 patients, provoked FOG during a standardized walking course was assessed. Using a publicly available model of basal-ganglia pathways we determined stimulation-dependent connectivity associated with postoperative changes in FOG. A region-of-interest analysis to a priori defined mesencephalic regions was performed using a disease-specific normative connectome. Results: Freezing of gait significantly improved six months postoperatively, marked by reduced frequency and duration of freezing episodes. Optimal stimulation volumes for improving FOG structurally connected to motor areas, the prefrontal cortex and to the globus pallidus. Stimulation of the lenticular fasciculus was associated with worsening of FOG. This connectivity profile was robust in a leave-one-out cross-validation. Subcortically, stimulation of fibers crossing the pedunculopontine nucleus and the substantia nigra correlated with postoperative improvement. Conclusion: STN-DBS can alleviate FOG severity by modulating specific pathways structurally connected to prefrontal and motor cortices. More differentiated FOG assessments may allow to differentiate pathways for specific FOG subtypes in the future.

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“… Comparison Archimedes’ of spirals, stimulation parameters and Volume of Tissue Activation (VTA) in red. Using preoperative MRI and postoperative CT imaging, the VTA was modeled from patient stimulation parameters and created with LeadDBS [ 21 ] and Fastfield [ 22 ], which does not take frequency into account. The VTA represents simulation meant to target the VIM, seen as time progresses.…”

Section: Case Descriptionmentioning

confidence: 99%

Deep Brain Stimulation of the Ventral Intermediate Nucleus of the Thalamus in Writer’s Cramp: A Case Report

Hirt

Grassia

Feuerstein

et al. 2021

Tremor and Other Hyperkinetic Movements

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FastField: An open-source toolbox for efficient approximation of deep brain stimulation electric fields

Cited by 39 publications

References 41 publications

Sweetspot Mapping in Deep Brain Stimulation: Strengths and Limitations of Current Approaches

Sweetspot Mapping in Deep Brain Stimulation: Strengths and Limitations of Current Approaches

Structural Connectivity of Subthalamic Nucleus Stimulation for Improving Freezing of Gait

Deep Brain Stimulation of the Ventral Intermediate Nucleus of the Thalamus in Writer’s Cramp: A Case Report

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