Fasting but not changes of plasma metabolome during oral glucose tolerance tests improves the diagnosis of severe coronary arterial stenosis

Hung, Chi Sheng; Li, Hung Yuan; Kuo, Ching‐Hua; Lin, Mao Shin; Kuo, Tsun-Cheng; Tsai, Sung Jeng; Liu, Pi-Hua; Lin, Cheng Hsin; Yang, C. Y.; Chuang, Lee‐Ming; Chen, Ming Fong; Tseng, Yufeng J.; Kao, Hsien‐Li

doi:10.1111/cen.12713

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…From 2008 to 2009, we conducted a cross-sectional study at National Taiwan University Hospital. 39 Subjects who were suspected to have CAD based on positive results of noninvasive stress tests and who received selective coronary angiography were invited to participate in this study. All subjects were evaluated by cardiologists.…”

Section: Patientsmentioning

confidence: 99%

Inhibition of semicarbazide-sensitive amine oxidase reduces atherosclerosis in apolipoprotein E-deficient mice

Wang

Tsai

et al. 2018

Translational Research

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Inflammation, oxidative stress, and formation of advanced glycated end products (AGEs) and advanced lipoxidation end products (ALEs) are important for atherosclerosis. Vascular adhesion protein-1 (VAP-1) participates in inflammation and has semicarbazide-sensitive amine oxidase (SSAO) activity, which catalyzes oxidative deamination to produce hydrogen peroxide and aldehydes, leading to generation of AGEs and ALEs. However, the effect of VAP-1/SSAO inhibition on atherosclerosis remains controversial, and no studies used coronary angiography to evaluate if plasma VAP-1/SSAO is a biomarker for coronary artery disease (CAD). Here, we examined if plasma VAP-1/SSAO is a biomarker for CAD diagnosed by coronary angiography in humans and investigated the effect of VAP-1/SSAO inhibition by a specific inhibitor PXS-4728A on atherosclerosis in cell and animal models. In the study, VAP-1/SSAO expression was increased in plaques in humans and in apolipoprotein E (ApoE)-deficient mice, and colocalized with vascular endothelial cells and smooth muscle cells (SMCs). Patients with CAD had higher plasma VAP-1/SSAO than those without CAD. Plasma VAP-1/SSAO was positively associated with the extent of CAD. In ApoE-deficient mice, VAP-1/SSAO inhibition reduced atheroma and decreased oxidative stress. VAP-1/SSAO inhibition attenuated the expression of adhesion molecules, chemoattractant proteins, and proinflammatory cytokines in the aorta, and suppressed monocyte adhesion and transmigration across human umbilical vein endothelial cells. Consequently, the expression of markers for macrophage recruitment and activation in plaques was decreased by VAP-1/SSAO inhibition. Besides, VAP-1/SSAO inhibition suppressed proliferation and migration of A7r5 SMC. Our data suggest that plasma VAP-1/SSAO is a novel biomarker for the presence and the extent of CAD in humans. VAP-1/SSAO inhibition by PXS-4728A is a potential treatment for atherosclerosis.

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Section: Patientsmentioning

confidence: 99%

Inhibition of semicarbazide-sensitive amine oxidase reduces atherosclerosis in apolipoprotein E-deficient mice

Wang

Tsai

et al. 2018

Translational Research

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“…2008; Hung et al. 2015). The onset of CHD is often characterized by coronary atherosclerosis (AS) and it is widely believed that AS results from the interaction of various risk factors (Duncan et al.…”

Section: Introductionmentioning

confidence: 99%

Effects of huoxin formula on the arterial functions of patients with coronary heart disease

et al. 2019

Pharmaceutical Biology

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Context: Huoxin formula is a Traditional Chinese Medicine for coronary heart disease (CHD) treatment. Objective: To explore the therapeutic mechanism of the Huoxin formula on arterial functions in CHD patients. Materials and methods: Fifty-eight CHD patients receiving cardiovascular drugs including β-receptor blocker, statins, and antiplatelet medications or others were randomized into intervention [additionally 13.5 g Huoxin formula granules dissolved in 150 mL warm water per time, twice a day ( n = 30)] and control [only cardiovascular drugs ( n = 28)] groups. Serum biomarkers (hs-CRP, IL-18, IL-17, TNF-α, MMP-9), and cardiovascular indicators of the common and internal carotid arteries (ICAs) were monitored before and after the treatments. Results: After 3 months of treatment, the increases of intima-media thicknesses (IMT) of the left and right common carotid arteries (CCAs) as well as of the left and right ICAs and the increases of the left and right cardio-ankle vascular index were all significantly (all p < 0.001) less in the intervention than in control group (all p < 0.001). Serum concentrations reductions of hs-CRP, IL-18, IL-17 and MMP9 (all p < 0.001) levels were higher in the intervention compared to the control group, which correlated with the changes of left ICA (hs-CRP: r = 0.581, p = 0.009; IL-18: r = 0.594, p = 0.007; IL-17: r = 0.575, p = 0.006). Discussion and conclusion: Since the Huoxin formula improved arterial functions and reduced inflammatory factor activities in CHD patients, a large-scale clinical trial is warranted.

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Metabolomics, a promising approach to translational research in cardiology

Deidda

Piras

Bassareo

et al. 2015

IJC Metabolic & Endocrine

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The metabolome is the complete set of metabolites found in a biological cell, tissue, organ or organism, representing the end products of cellular processes. Metabolomics is the systematic study of small-molecule metabolite profiles produced by specific cellular processes. mRNA gene expression data and proteomic analyses do not show the complexity of physiopathological processes that occur in a cell, tissue or organism. Metabolic profiling, in contrast, represents a paradigm shift in medical research from approaches that focus on a limited number of enzymatic reactions or single pathways, with the goal of capturing the complexity of metabolic networks. In this article, we will provide a description of metabolomics in comparison with other, better known "omics" disciplines such as genomics and proteomics. In addition, we will review the current rationale for the implementation of metabolomics in cardiology, its basic methodology and the available data from human studies in this discipline. The topics covered will delineate the importance of being able to use the metabolomic information to understand the mechanisms of diseases from the perspective of systems biology, and as a non-invasive approach to the diagnosis, grading and treatment of cardiovascular diseases

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Fasting but not changes of plasma metabolome during oral glucose tolerance tests improves the diagnosis of severe coronary arterial stenosis

Abstract: Fasting plasma metabolome, but not change of plasma metabolome during OGTT, can improve the diagnosis of significant stenosis in patients with positive noninvasive stress test results.

Cited by 3 publications

References 23 publications

Inhibition of semicarbazide-sensitive amine oxidase reduces atherosclerosis in apolipoprotein E-deficient mice

Inhibition of semicarbazide-sensitive amine oxidase reduces atherosclerosis in apolipoprotein E-deficient mice

Effects of huoxin formula on the arterial functions of patients with coronary heart disease

Metabolomics, a promising approach to translational research in cardiology

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