Fasting plasma glucose levels in healthy preschool children: effects of weight and lifestyle

Ludvigsson, Johnny; Huus, Karina; Eklöv, Kristina; Klintström, Rebecka; Lahdenperä, Anne

doi:10.1111/j.1651-2227.2007.00253.x

Cited by 10 publications

(14 citation statements)

References 26 publications

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“…Breastfeeding and the later introduction of weaning foods have been found to contribute to faster growth during the first few months, followed by a slowing of growth and a lower BMI and in most studies also a lower length at 1 year of age (13,25,26). Breastfeeding also protects against early overweight (26), whereas smoking in pregnancy increases the risk for overweight (25–27). For the Danish children in this study, Greve also found that smoking during pregnancy and maternal and paternal overweight increased the risk of overweight at age 7.4 years, whereas children of mothers working fulltime had decreased risks if the children had earlier attended institutional day care.…”

Section: Discussionmentioning

confidence: 99%

New Danish reference values for height, weight and body mass index of children aged 0–5 years

2010

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Section: Discussionmentioning

confidence: 99%

New Danish reference values for height, weight and body mass index of children aged 0–5 years

2010

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“…3A, p < 0.001). More moderate reductions in blood glucose levels to 4 m m (approximately 40%), which represent a plausible fasting level (Ludvigsson et al., 2007), also significantly increased the frequency of SWDs by approximately twofold in these mice (Fig. 3B, p < 0.001).…”

Section: Resultsmentioning

confidence: 85%

Low blood glucose precipitates spike-and-wave activity in genetically predisposed animals

et al. 2010

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SUMMARYPurpose: Absence epilepsies are common, with a major genetic contribution to etiology. Certain environmental factors can influence absence occurrence but a complete understanding of absence precipitation is lacking. Herein we investigate if lowering blood glucose increases spikewave activity in mouse models with varying seizure susceptibility. Methods: Three mouse models were used: an absence seizure model based on the knockin of a human GABA A c2(R43Q) mutation (DBA(R43Q)), the spike-wave discharge (SWD)-prone DBA/2J strain, and the seizure resistant C57Bl/6 strain. Electrocorticography (ECoG) studies were recorded to determine SWDs during hypoglycemia induced by insulin or overnight fasting. Key Findings: An insulin-mediated reduction in blood glucose levels to 4 mM (c.a. 40% reduction) was sufficient to double SWD occurrence in the DBA(R43Q) model and in the SWD-prone DBA/2J mouse strain. Larger reductions in blood glucose further increased SWDs in both these models. However, even with large reductions in blood glucose, no discharges were observed in the seizure-resistant C57Bl/6 mouse strain. Injection of glucose reversed the impact of insulin on SWDs in the DBA(R43Q) model, supporting a reduction in blood glucose as the modulating influence. Overnight fasting reduced blood glucose levels to 4.5 mM (c.a. 35% reduction) and, like insulin, caused a doubling in occurrence of SWDs. Significance: Low blood glucose can precipitate SWDs in genetically predisposed animal models and should be considered as a potential environmental risk factor in patients with absence epilepsy.

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“…All 16 studies reported that outdoor time was positively related to physical activity. Physical activity was assessed in a variety of ways in these studies including pedometer steps counts [ 28 , 29 ], accelerometer readings of total physical activity [ 30 , 31 ] and MVPA [ 31 , 32 , 33 , 34 , 35 , 36 ], parent- and self-reported leisure time physical activity [ 37 , 38 ], and observed total physical activity and MVPA [ 39 , 40 , 41 , 42 , 43 , 44 ]. The results were consistent across sexes and different age groups.…”

Section: Resultsmentioning

confidence: 99%

What Is the Relationship between Outdoor Time and Physical Activity, Sedentary Behaviour, and Physical Fitness in Children? A Systematic Review

Gray

Gibbons

Larouche

et al. 2015

IJERPH

327

239

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The objective of this systematic review was to examine the relationship between outdoor time and: (1) physical activity, (2) cardiorespiratory fitness, (3) musculoskeletal fitness, (4) sedentary behaviour; or (5) motor skill development in children aged 3–12 years. We identified 28 relevant studies that were assessed for quality using the GRADE framework. The systematic review revealed overall positive effects of outdoor time on physical activity, sedentary behaviour, and cardiorespiratory fitness, although causality could not be assumed due to a lack of RCTs. Motor skill development was unrelated to outdoor time; however, this relationship was only examined in a single study of preschool children. No studies were found that examined associations between outdoor time and musculoskeletal fitness.

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Fasting plasma glucose levels in healthy preschool children: effects of weight and lifestyle

Abstract: A modern lifestyle, with low levels of exercise and high-energy consumption, may explain the increasing weight and even obesity of otherwise healthy, preschool children, but does not influence their fasting plasma glucose levels.

Cited by 10 publications

References 26 publications

New Danish reference values for height, weight and body mass index of children aged 0–5 years

New Danish reference values for height, weight and body mass index of children aged 0–5 years

Low blood glucose precipitates spike-and-wave activity in genetically predisposed animals

What Is the Relationship between Outdoor Time and Physical Activity, Sedentary Behaviour, and Physical Fitness in Children? A Systematic Review

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