Fasting Serum Ghrelin Levels Is Negatively Associated With Body Mass Index, Cholesterol, Triglyceride and C-Reactive Protein

Cebeci, Defne; Tülüceoğlu, Eda Evgen; Gonca, Taner; Calapoğlu, Nilüfer Şahin; Öztürk, Önder; Calapoğlu, Mustafa

doi:10.17343/sdutfd.422561

SDÜ Tıp Fakültesi Dergisi

2019

DOI: 10.17343/sdutfd.422561

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Fasting Serum Ghrelin Levels Is Negatively Associated With Body Mass Index, Cholesterol, Triglyceride and C-Reactive Protein

Defne Cebeci¹,

Eda Evgen Tülüceoğlu²,

Taner Gonca³

et al.

Abstract: Bu çalışmanın amacı, vücut kitle indeksi (VKİ) kriterlerine göre normal ağırlıktan morbid obeze kadar gruplandırılan erişkin erkek ve kadın kohortunda grelin hormonunun VKİ, serum lipitleri ve C-reaktif protein (CRP) ile ilişkisini değerlendirmektir. Gereç ve Yöntem Isparta Gülkent Devlet Hastanesi Göğüs Hastalıkları Uyku Laboratuvarı ve Süleyman Demirel Üniversitesi Tıp Fakültesi Uyku Hastalıkları Merkezine başvuran 20-59 yaş arası toplam iki yüz altmış erkek (n=151) ve kadın (n=109) çalışmaya dahil edildi. T… Show more

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2024

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Differences in the levels of the appetite peptides ghrelin, peptide tyrosine tyrosine, and glucagon-like peptide-1 between obesity classes and lean controls

Alyar,

Umudum

2024

Laboratory Medicine

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Objective This study was designed to compare basal concentrations of the gastrointestinal appetite modulators ghrelin, peptide tyrosine tyrosine (PYY), and glucagon-like peptide 1 (GLP-1) between obesity classes and obesity classes and controls. Methods The study included 49 healthy controls with body mass index (BMI) between 18.5 and 29.9 kg/m² and 62 individuals with obesity with BMI ≥30 kg/m². Basal ghrelin, PYY, and GLP-1 concentrations of the samples were analyzed by an enzyme-linked immunosorbent assay commercial kit (SunRed Human). Other biochemical parameters were measured by a clinical chemistry autoanalyzer (Beckman Coulter AU 5800) in the biochemistry laboratory. Results Compared with the control group, ghrelin, PYY, and GLP-1 levels were significantly lower in the obese group (P < .05). The PYY concentration was significantly different between obese groups (P < .05). The PYY and GLP-1 levels were significantly different between obesity class I and obesity class III. In addition, ghrelin levels were significantly different between obesity class II and obesity class III. Correlation analysis revealed a negative correlation between BMI and serum ghrelin, GLP-1, and PYY concentrations. Conclusion Low basal ghrelin, GLP-1, and PYY hormones in the obese group compared with the control group indicate impaired appetite regulation in this population. The significant difference in PYY levels between obese groups was associated with increasing obesity grade.

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Differences in the levels of the appetite peptides ghrelin, peptide tyrosine tyrosine, and glucagon-like peptide-1 between obesity classes and lean controls

Alyar,

Umudum

2024

Laboratory Medicine

View full text Add to dashboard Cite

show abstract

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Fasting Serum Ghrelin Levels Is Negatively Associated With Body Mass Index, Cholesterol, Triglyceride and C-Reactive Protein

Cited by 1 publication

References 31 publications

Differences in the levels of the appetite peptides ghrelin, peptide tyrosine tyrosine, and glucagon-like peptide-1 between obesity classes and lean controls

Differences in the levels of the appetite peptides ghrelin, peptide tyrosine tyrosine, and glucagon-like peptide-1 between obesity classes and lean controls

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