Fasting Serum Glucose Level and Cancer Risk in Korean Men and Women

doi:10.1001/jama.293.18.2210-b

Cited by 6 publications

(6 citation statements)

References 19 publications

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“…Moreover, it also has been reported that higher levels of fasting plasma glucose have been associated with an increased breast cancer risk [47, 48]. However, some studies presented a different perspective that no significant association was found between serum glucose levels and breast cancer[49, 50]. A meta-analysis conducted by Boyle et al[51] also revealed that the risk of breast cancer associated with fasting serum glucose levels seems to be small.…”

Section: Discussionmentioning

confidence: 99%

Elevated Serum Levels of Retinol-Binding Protein 4 Are Associated with Breast Cancer Risk: A Case-Control Study

Jiao

Cui

et al. 2016

PLoS ONE

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BackgroundRetinol binding protein 4 (RBP4) is a recently identified adipokine that is elevated in patients with obesity or type 2 diabetes. A growing body of research has shown that RBP4 is associated with several types of cancer. However, no studies have investigated the relationship between serum RBP4 levels and breast cancer risk. We performed a case-control study to evaluate the association between serum RBP4 levels and the risk of breast cancer.MethodsFrom August 2012 to December 2013, four-hundred subjects including 200 patients diagnosed with primary breast cancer and 200 matched healthy women were consecutively enrolled from Affiliated Hospital of Qingdao University Medical College. Blood samples were collected from healthy controls and breast cancer patients before commencement of treatment. Enzyme-linked immunosorbent assay was used to evaluate the serum RBP4 levels in separated serum samples. Meanwhile, the characteristics of breast cancer cases and controls were collected from medical records and pathological data.ResultsThe serum levels of RBP4 were significantly higher in patients with breast cancer than that in the healthy control group (33.77±9.92 vs. 28.77±6.47μg/ml, P < 0.05). Compared to the subjects in the lowest quartile of serum RBP4 level, the adjusted ORs (95% CIs) is 2.16(1.01–4.61) and 2.07 (1.07–4.00) for women in the second and highest RBP4 tertile, respectively. For breast cancer patients, patients with PR or ER negative displayed significantly higher serum RBP4 levels than those with PR or ER positive.ConclusionOur results for the first time suggested serum RBP4 levels could be associated with the risk of breast cancer. However, further prospective studies are essential to confirm these observed results.

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Section: Discussionmentioning

confidence: 99%

Elevated Serum Levels of Retinol-Binding Protein 4 Are Associated with Breast Cancer Risk: A Case-Control Study

Jiao

Cui

et al. 2016

PLoS ONE

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“…The association between T2DM and cancer was reported more than 100 years ago [ 10 ]. Most epidemiological studies have suggested that cancers, particularly hepatic, pancreatic, colorectal, bladder, endometrial, and breast cancers, appear to be associated with T2DM, increasing the risk and mortality rates [ 1 , 3 , 6 , 11 – 20 ]. Each value of the estimated risk may differ because of the impact of variable and intermingling factors, such as ethnic differences—including genetic susceptibility, life-style behavior, and environmental exposure—across populations [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

The Association between Type 2 Diabetes Mellitus and Women Cancer: The Epidemiological Evidences and Putative Mechanisms

Joung

Jeong

2015

BioMed Research International

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Type 2 diabetes mellitus (T2DM), a chronic disease increasing rapidly worldwide, is well established as an important risk factor for various types of cancer. Although many factors impact the development of T2DM and cancer including sex, age, ethnicity, obesity, diet, physical activity levels, and environmental exposure, many epidemiological and experimental studies are gradually contributing to knowledge regarding the interrelationship between DM and cancer. The insulin resistance, hyperinsulinemia, and chronic inflammation associated with diabetes mellitus are all associated strongly with cancer. The changes in bioavailable ovarian steroid hormone that occur in diabetes mellitus (the increasing levels of estrogen and androgen and the decreasing level of progesterone) are also considered potentially carcinogenic conditions for the breast, endometrium, and ovaries in women. In addition, the interaction among insulin, insulin-like growth factors (IGFs), and ovarian steroid hormones, such as estrogen and progesterone, could act synergistically during cancer development. Here, we review the cancer-related mechanisms in T2DM, the epidemiological evidence linking T2DM and cancers in women, and the role of antidiabetic medication in these cancers.

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“…[17] A study conducted in Korea demonstrated a strong association between high levels of FBG and risk of liver cancer in males (HR = 1.7, 95% CI: 1.5–1.8) and females (HR = 1.2, 95% CI: 1.0–1.4) after adjustments were made for age, smoking, and alcohol use. [18] However, studies concerning 578,700 Europeans and 2903 male Taiwanese failed to find such a relationship. [19,20] Even an inverse relationship between FBG and HCC had been reported in 2 studies, neither of which reached statistical significance though.…”

Section: Discussionmentioning

confidence: 99%

Elevated fasting serum glucose levels increase the risk of hepatocellular carcinoma

et al. 2019

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Fasting Serum Glucose Level and Cancer Risk in Korean Men and Women

Abstract: For editorial comment see p 235.

Cited by 6 publications

References 19 publications

Elevated Serum Levels of Retinol-Binding Protein 4 Are Associated with Breast Cancer Risk: A Case-Control Study

Elevated Serum Levels of Retinol-Binding Protein 4 Are Associated with Breast Cancer Risk: A Case-Control Study

The Association between Type 2 Diabetes Mellitus and Women Cancer: The Epidemiological Evidences and Putative Mechanisms

Elevated fasting serum glucose levels increase the risk of hepatocellular carcinoma

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