Fasting serum insulin levels and insulin resistance are associated with blood rheology in Japanese young adults without diabetes

Yoshida, Kan; Kimura, Takao; Aoki, Tomoyuki; Tsunekawa, Katsuhiko; Araki, Osamu; Shoho, Yoshifumi; Nara, Makoto; Sumino, Hiroyuki; Murakami, Masami

doi:10.1177/0300060515627561

Cited by 16 publications

(13 citation statements)

References 50 publications

(115 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies using MC-FAN indicated that mean WBPT values in patients without diabetes mellitus or healthy controls are approximately 40 s degree [ 23 , 24 ], whereas mean WBPT values in this study were 62.5 s. Thus, these results indicated that the impairment of hemorheology in patients with type 2 diabetes mellitus was progressive compared with that in nondiabetic or healthy controls. Furthermore, independent associations between WBPT and hs-cTnT levels suggest that the impairment of hemorheology is an important factor for the progression of subclinical myocardial injury or primary cardiovascular incidence in patients with type 2 diabetes mellitus.…”

Section: Discussioncontrasting

confidence: 55%

Association of Hemorheology With High-Sensitivity Cardiac Troponin T Levels in Patients With Type 2 Diabetes Mellitus Assessed by Microchannel Array Flow Analyzer

Hatori¹

2017

Cardiol Res

View full text Add to dashboard Cite

BackgroundRecent studies on high-sensitivity cardiac troponin T (hs-cTnT) and whole blood passage time (WBPT), estimated by hemorheology assessed with the microchannel array flow analyzer (MC-FAN), have revealed the significance of cardiovascular risk factors. However, there are no known reports on the relationship between these two clinical parameters. This cross-sectional study aimed to clarify the associations between WBPT and hs-cTnT levels in patients with type 2 diabetes mellitus from the perspective of subclinical myocardial injury or the primary prevention of cardiovascular events.MethodsA total of 301 outpatients (men, 116; women, 185; mean age, 65 ± 11 years), with no history of cardiovascular diseases, undergoing treatment for diabetes mellitus were enrolled. Hs-cTnT levels and WBPT were measured using a commercial device, and the relationship between hs-cTnT levels and various clinical parameters, including WBPT, was examined.ResultsHs-cTnT levels were detected in 261 (86.7%) patients. WBPT was significantly higher in patients with detectable hs-cTnT levels than in those with undetectable hs-cTnT levels (64 ± 18 s vs. 51 ± 13 s, P < 0.001). In patients with detectable hs-cTnT levels, there was a significantly positive correlation between WBPT and hs-cTnT levels (r = 0.40; P < 0.001). Furthermore, multiple regression analysis revealed that WBPT (β = 0.24; P < 0.001) was an independent variable when hs-cTnT was a subordinate factor. Conversely, patients with high (≥ 70 s; odds ratio, 5.3 (95% CI, 1.6 - 16.1); P < 0.01) and median (50.2 - 69.8 s; odds ratio, 3.8 (95% CI, 1.2 - 12.4); P < 0.05) WBPT had a significantly higher risk for high hs-cTnT levels (≥ 0.014 ng/mL) than those with low WBPT (≤ 50.0 s).ConclusionsThe results of this study indicated independent associations of hemorheology with hs-cTnT in patients with type 2 diabetes mellitus assessed by MC-FAN. We suggest that an increase in hs-cTnT levels can be prevented by maintaining WBPT at ≤ 50.0 s.

show abstract

Section: Discussioncontrasting

confidence: 55%

Association of Hemorheology With High-Sensitivity Cardiac Troponin T Levels in Patients With Type 2 Diabetes Mellitus Assessed by Microchannel Array Flow Analyzer

Hatori¹

2017

Cardiol Res

View full text Add to dashboard Cite

show abstract

“…A recent Japanese clinical study using MC-FAN indicated that the mean WBPT values in patients without diabetes mellitus and in healthy control subjects were 39.9 and 37.1 s, respectively [19,20]. The mean WBPT of the patients in the present study was 61.3 s, indicating that blood rheology was impaired in patients with type 2 diabetes mellitus.…”

Section: Discussionsupporting

confidence: 48%

Relationship between cardiovascular risk factors and hemorheology assessed by microchannel method in patients with type 2 diabetes mellitus

Hatori¹

2017

Diabetol Int

View full text Add to dashboard Cite

Aim In addition to atherosclerosis, impairment of blood rheology is an important factor in cardiovascular events. The present study attempted to clarify the relationship between hemorheology and cardiovascular risk factors in patients with type 2 diabetes mellitus assessed by a microchannel method. Methods We enrolled 294 patients with type 2 diabetes mellitus (109 males and 185 females; mean age, 69 ± 11 years) with no history of cardiovascular events. Hemorheology was evaluated with a microchannel array flow analyzer, and the relationship between whole-blood passage time (WBPT) and various clinical parameters was examined. Results WBPT was significantly correlated with advanced glycation end-product (AGE) levels at the skin (r = 0.49, p \ 0.001), serum reactive oxygen metabolite concentrations (oxidative stress markers) (r = 0.25, p \ 0.001), the cardio-ankle vascular index (CAVI, arterial function marker) (r = 0.32, p \ 0.001), and a number of classical cardiovascular risk factors in an individual (r = 0.45, p \ 0.001). Multiple regression analysis revealed that these factors were selected as independent variables for WBPT as a subordinate factor. Conclusion Hemorheology is significantly associated with novel cardiovascular risk factors, such as AGEs, in vivo oxidative stress, and CAVI, and clustering of classical cardiovascular risk factors in patients with type 2 diabetes mellitus.

show abstract

“…Several cross-sectional studies have assessed WBPT in healthy populations or in patients with cardiovascular risk factors, with the results suggesting that the cut-off value for cardiovascular risk is 50 - 70 s [ 10 , 16 - 18 ]. Based on these previous results, the present study prospectively divided the participants into three groups according to two simple cut-off levels of 50 s and 70 s. The results showed that participants with WBPT > 70 s were a population at high risk of primary cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

“…MC-FAN can be used to measure the whole blood passage time (WBPT). Cross-sectional studies have reported significant relationships between an increase in WBPT and cardiovascular risk factors or cardiovascular disease [ 7 - 10 ]. However, there have been no prospective studies of the clinical usefulness of WBPT as a predictor of cardiovascular events.…”

Section: Introductionmentioning

confidence: 99%

Usefulness of the Whole Blood Passage Time as a Predictor of Primary Cardiovascular Events in Patients With Traditional Cardiovascular Risk Factors

Hatori¹

2018

Cardiol Res

View full text Add to dashboard Cite

BackgroundRecent clinical studies have reported that impaired hemorheology is a significant cardiovascular risk factor, but there has been no prospective study of its relationship with cardiovascular events. The aim of this prospective study was to assess the efficacy of whole blood passage time (WBPT), measured by a microchannel array flow analyzer (MC-FAN), as a predictor of primary cardiovascular events in patients with traditional cardiovascular risk factors.MethodsThe study enrolled 1,134 outpatients with traditional cardiovascular risk factors but no history of cardiovascular events (438 men and 696 women; mean ± standard deviation age, 67 ± 11 years). Based on the value of WBPT, the patients were assigned to one of three groups: L (low, WBPT < 50 s; n = 499), M (medium, WBPT 50 - 70 s; n = 295), or H (high, WBPT > 70 s; n = 340). The utility of the WBPT as a predictor of primary cardiovascular events was evaluated.ResultsDuring the follow-up period (median 81.9 months), major adverse cardiovascular events (MACE) occurred in 95 cases (L, 21 cases (4.2%); M, 24 cases (8.1%); H, 50 cases (14.7%); P < 0.001, log-rank test). In multivariate Cox regression analyses, the risk for MACE was significantly higher in group H than in group L (hazard ratio, 2.32; 95% confidence interval, 1.31 - 3.20; P < 0.01). A WBPT cut-off of 72.4 s yielded the largest area under the curve of 0.705 (95% confidence interval: 0.678 - 0.732), with a sensitivity of 51.7% and specificity of 85.4% for discriminating between those who did and did not experience MACE during the follow-up period.ConclusionThis study showed that WBPT evaluated by a MC-FAN was a predictor of primary cardiovascular events in patients with traditional cardiovascular risk factors.

show abstract

Fasting serum insulin levels and insulin resistance are associated with blood rheology in Japanese young adults without diabetes

Cited by 16 publications

References 50 publications

Association of Hemorheology With High-Sensitivity Cardiac Troponin T Levels in Patients With Type 2 Diabetes Mellitus Assessed by Microchannel Array Flow Analyzer

Association of Hemorheology With High-Sensitivity Cardiac Troponin T Levels in Patients With Type 2 Diabetes Mellitus Assessed by Microchannel Array Flow Analyzer

Relationship between cardiovascular risk factors and hemorheology assessed by microchannel method in patients with type 2 diabetes mellitus

Usefulness of the Whole Blood Passage Time as a Predictor of Primary Cardiovascular Events in Patients With Traditional Cardiovascular Risk Factors

Contact Info

Product

Resources

About