Fat Injection to Correct Contour Deformities in the Reconstructed Breast

Spear, Scott L.; Wilson, Henry B.; Lockwood, M.

doi:10.1097/01.prs.0000181509.67319.cf

Cited by 242 publications

(121 citation statements)

References 17 publications

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“…Risk of cancer development or cancer recurrence related to fat grafting has not been addressed in the recent clinical studies [3,34]. Breast cancer can recur years or even decades after the original treatment [35][36].…”

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confidence: 99%

Interaction of human adipose tissue-derived mesenchymal stromal cells with breast cancer cells

Kučerová¹,

Kovacovicova²,

Polák³

et al. 2011

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Human adipose tissue was shown to be a very attractive source of mesenchymal stromal cells that have a wide scale of potential applications in reconstructive plastic surgery and regenerative medicine. However, these cells were described to have profound effects on biological behaviour of tumour cells. The aim of this study was to analyze the influence of adipose tissue-derived human mesenchymal stromal cells (AT-MSC) on the proliferation of breast cancer cells. We have tested proliferation of three different human breast cancer cell lines under the influence of AT-MSC derived soluble factors as well as in the direct cocultures. These data were supplemented with the expression analysis of cytokines and their cognate receptors on the target cells. We have observed stimulation of proliferation in breast cancer cells MDA-MB-361, T47D and EGFP-MCF7. AT-MSC were found to secrete wide scale of cytokines, chemokines and growth factors, thus we concluded that this pro-proliferative effect was a result of their synergistic action. These data bring out a need to evaluate whether primary breast tumour derived human cells would respond to these type of stimuli in a similar manner in order to exclude any potential clinical risk related to the application of human mesenchymal stromal cells under the context of patient with history of breast cancer malignancy.

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confidence: 99%

Interaction of human adipose tissue-derived mesenchymal stromal cells with breast cancer cells

Kučerová¹,

Kovacovicova²,

Polák³

et al. 2011

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“…A review of the literature reveals there are a growing number of published reports on the use of fat grafting in breast reconstruction after surgery for breast cancer. While some of them are case reports (Del Vecchio 2009, Babovic 2010, Panettiere 2011, Fitoussi 2009), a considerable number describe their experience with 40 or more patients (Spear 2005, Serra-Renom 2010, Rietjens 2011, Losken 2011, Missana 2007, Delay 2008, Panettiere 2009, Kanchwala 2009). …”

Section: The Emerging Role Of Fat Grafting In Breast Reconstructionmentioning

confidence: 99%

Autologous Fat Transplantation – A Paradigm Shift in Breast Reconstruction

Vecchio¹,

Fichadia²

2012

Breast Reconstruction - Current Techniques

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“…Autologous fat transplantation (AFT) shows great potential in repairing soft tissue defects caused by trauma, tumor resection and congenital anomalies due to incisional scar-free and minimal complications (Spear et al 2005;Coleman and Saboeiro 2007). Furthermore, AFT has been considered as a promising alternative to artificial tissue implants Knippenberg et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Adipose Tissue-Derived Stem Cells Treated with Estradiol Enhance Survival of Autologous Fat Transplants

Luo

Hao

et al. 2013

Tohoku J. Exp. Med.

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Autologous fat transplantation (AFT) is a common and important operation in plastic surgery for soft tissue defects and adipose tissue-derived stem cells (ADSCs) are considered as a promising supplement to decrease absorption and subsequent side effects due to the ability of multiple differentiation and production of vascular endothelial growth factor (VEGF). The capacities of ADSCs can be further enhanced by treatment with 17-β estradiol (E2). Therefore, we hypothesized that E2 may promote the potential of ADSCs for AFT. In this study, ADSCs were extracted from three female patients by liposuction. In vitro studies showed that E2 supplementation at an optimal concentration of 10 -8 M resulted in enhanced proliferation, VEGF production, and adipogenic differentiation of human ADSCs, and reduced apoptosis rate in a serum-free environment. In addition, a nude mice model of fat transplantation was utilized to demonstrate the efficacy of ADSC for survival ratio in vivo. These results using the volume of fat tissues after 12 weeks compared original volume, revealed that the addition of E2-treated ADSCs induced a significantly higher tissue survival ratio (76.9 ± 1.9%) when compared with the ADSC-free system (55.5 ± 1.5%). Furthermore, increased capillary formation stained with hematoxylin-eosin (H&E) was observed in ADSCs systems after treatment with E2. Therefore, this study demonstrated E2 could promote the capacities of ADSCs about aspects of adipogenic differentiation, growth factor secretion and apoptosis reduction in vitro, vascularization improvement in vivo, and then enhanced the survival ratio of AFT.

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Fat Injection to Correct Contour Deformities in the Reconstructed Breast

Cited by 242 publications

References 17 publications

Interaction of human adipose tissue-derived mesenchymal stromal cells with breast cancer cells

Interaction of human adipose tissue-derived mesenchymal stromal cells with breast cancer cells

Autologous Fat Transplantation – A Paradigm Shift in Breast Reconstruction

Adipose Tissue-Derived Stem Cells Treated with Estradiol Enhance Survival of Autologous Fat Transplants

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