Fat Transplantation Using Fresh Versus Frozen Fat: A Side-by-Side Two-Hand Comparison Pilot Study

Butterwick, Kimberly J.; Bevin, Avery A.; Iyer, Srinivasan

doi:10.1111/j.1524-4725.2006.32135.x

Cited by 29 publications

(44 citation statements)

References 14 publications

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“…Until now the limited cosmetic use of HA in the hands has mainly been aimed at purely reproducing the volume effect previously created by procedures such as fat augmentation 1,6,11 . Micropuncture placement of HA aimed at restoring volume and changing skin physiology to reflect that of younger skin (skin revitalization) is a new concept and has not yet been formally evaluated on the backs of the hands.…”

Section: Discussionmentioning

confidence: 99%

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Changes in skin physiology and clinical appearance after microdroplet placement of hyaluronic acid in aging hands

Williams

Tamburić

Stensvik

et al. 2009

J of Cosmetic Dermatology

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Section: Discussionmentioning

confidence: 99%

“…Prominent superficial veins can be treated with sclerotherapy 9 . Studies looking at restoration of a more youthful fullness are limited and primarily involve autologous fat injections 6,9–11 …”

Section: Introductionmentioning

confidence: 99%

Changes in skin physiology and clinical appearance after microdroplet placement of hyaluronic acid in aging hands

Williams

Tamburić

Stensvik

et al. 2009

J of Cosmetic Dermatology

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“…Las células madre se emplean actualmente en medicina regenerativa y se espera que en un futuro más o menos próximo se puedan utilizar en el tratamiento de enfermedades como la diabetes, enfermedades cardiovasculares, lesiones medulares y enfermedades neuroló-gicas (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Todo parece indicar que la medicina del futuro estará ligada a la medicina regenerativa y a la utilización de células madre autólogas.…”

Section: Introductionunclassified

“…Además las células grasas de linaje específico (CD44++/45-/73+/90+) pueden ser conservadas a baja temperaturas durante largos periodos de tiempo, manteniendo todo su potencial (6,8,12,13) hasta el momento de ser reutilizadas en beneficio del paciente.…”

Section: Introductionunclassified

Obtención y criopreservación de células madre del tejido graso mediante liposucción

Ribo¹

2011

Cir. plást. iberolatinoam.

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ResumenExisten diferentes técnicas para la obtención directa de células madre embrionarias a través de embriones criopreservados en nitrógeno líquido (-196 °C), blastómeros individuales, activación de ovocitos por transferencia nuclear y células madre del líquido amniótico. También es posible obtener cé-lulas madre adultas hematopoyéticas y de la médula ósea, más conocidas y empleadas en la clínica desde hace tiempo, así como también de la sangre del cordón umbilical en recién nacidos y de la grasa corporal en adultos.La grasa autóloga corporal extraída mediante liposucción se reutiliza en ocasiones para injertar o infiltrar otras zonas corporales y faciales como material de relleno, pero en la mayoría de los casos es desechada. Por lo general, para obtener un resultado satisfactorio en el trasplante de grasa autóloga, son necesarios varios tiempos quirúrgicos por lo que sería muy útil contar con un banco de tejido adiposo personalizado. Existen diferentes estudios que demuestran que el tejido adiposo aspirado por liposucción convencional puede preservarse y almacenarse con éxito a baja temperatura (-85 °C) en banco de tejido para futuras aplicaciones.Las células madre mesenquimales (MSCs) poseen gran capacidad de proliferación y diferenciación con un alto valor terapéutico. El tejido graso es un reservorio importante de MSCs capaces de diferenciarse en tejido óseo, cartilaginoso, muscular, etc. Si reservamos una pequeña cantidad del tejido graso lipoaspirado, podemos obtener una cantidad suficiente de MSCs y conservarlas mediante un método óptimo de criopreservación.En 2007 realizamos un estudio de la grasa lipoaspirada en 36 pacientes para demostrar y validar el método de obtención de tejido graso con su posterior traslado, manipulación y criopreservación en banco de células madre. Los resultados fueron satisfactorios y en junio del 2010 se validó el método de recogida, procesamiento y almacenamiento de una mezcla enriquecida de células madre adultas de tejido graso aspirado. Dicho método permite a todas aquellas personas que no hayan tenido la oportunidad de almacenar su cordón umbilical al nacer, almacenar MSCs obtenidas de la grasa de liposucción.La criopreservación conservará las células durante años que, en el momento de ser requeridas por el paciente, se descongelarán, pudiéndose recuperar alrededor del 80% de las mismas.Palabras clave Células madre, Liposucción, Criopreservación. Código numérico 19-266 AbstractThere are different techniques to obtain embryonic stem cells directly through cryopreserved embryos in liquid nitrogen (-196ºC), individual blastomers, ovocyte activation by nuclear transfer and stem cells from amniotic fluid, among others. It is also possible to obtain hematopoietic adult stem cells and those from the bone marrow, better well-known and used in clinics for a long time; besides, from the blood of umbilical cord in newborns and body fat in adults.The autologous fat extracted from the body using liposuction, is sometimes reused to inject or infiltrate other body and facial areas as ...

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“…Skin normally contains the highest concentration of hyaluronic acid within the body. However, with time, there is a progressive depletion of endogenous HA [11]. HA has been implicated in a number of processes during early wound healing, including cell migration and proliferation [12], organization of granulation tissue, stimulating angiogenesis, and moderating the inflammatory response [12,13].…”

mentioning

confidence: 99%

Nonanimal Stabilized Hyaluronic Acid for Tissue Augmentation of the Dorsal Hands: A Prospective Study on 38 Patients

et al. 2012

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Background Often ignored, hands are one of the most telltale signs of aging. This prospective study was initiated to evaluate the effect of subcutaneous hyaluronic acid (HA) injections in aging hands, with special attention to complications and long-term outcomes. Methods Between January 2010 and December 2010, a total of 38 patients with skin phototypes II-IV and between 58 and 76 years old were treated with HA injection for aging hands. The quantity of injection never exceeded 1.0-1.5 ml HA per hand. A clinical follow-up was performed at 2 weeks, 4 weeks, 3 months, and 6 months after injection. Complications were reviewed for the whole series. At the first follow-up, 2 weeks after the procedure, ultrasound was carried out to determine if additional filling material was required. At each follow-up, patients were asked to fill out a satisfaction questionnaire. Results Nine patients developed slight ecchymosis that disappeared after 1 week. No other complications were seen in the series. Pain during the injection and discomfort after the procedure were minimal. At the 2-week follow-up, after ultrasound control, nine patients received a complementary injection. At each follow-up, overall patient satisfaction was high and was validated by clearance of rhytids, veins, bony prominences, and dermal and subcutaneous atrophy. Conclusion Skin revitalization with injectable HA can improve the clinical appearance of the back of the hands. However, this therapy requires knowledge of the possible complications and their remediation as well as knowledge and respect of injected doses. Moreover, despite excellent results at each follow-up, the results of our series are not as good after 6 months, and a longer follow-up would be needed to determine if this procedure provides long-lasting benefit.

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Fat Transplantation Using Fresh Versus Frozen Fat: A Side-by-Side Two-Hand Comparison Pilot Study

Abstract: This pilot study supports the use of autologous frozen fat for equivalent to improved results regarding longevity and aesthetic appearance versus fresh fat at 1, 3, and 5 months for fat augmentation of aging hands.

Cited by 29 publications

References 14 publications

Changes in skin physiology and clinical appearance after microdroplet placement of hyaluronic acid in aging hands

Changes in skin physiology and clinical appearance after microdroplet placement of hyaluronic acid in aging hands

Obtención y criopreservación de células madre del tejido graso mediante liposucción

Nonanimal Stabilized Hyaluronic Acid for Tissue Augmentation of the Dorsal Hands: A Prospective Study on 38 Patients

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