Fatal, complete splenic infarction and hepatic infection due to disseminated Trichosporon beigelii infection

Abstract

We report on a 56-year-old woman with acute lymphocytic leukemia who presented with right upper quadrant pain, fever, nausea, and vomiting. Laboratory studies confirmed fungemia with Trichosporum beigelii, and contrast-enhanced computed tomography of the abdomen demonstrated numerous low-attenuation liver lesions and a hypodense spleen with capsular enhancement suggestive of complete splenic infarction. Subsequent splenectomy confirmed that the spleen was completely infarcted and infiltrated with Trichosporum. The patient had a difficult postoperative course and died despite aggressive antifungal therapy.

Invasive Trichosporon Infection: a Systematic Review on a Re-emerging Fungal Pathogen

“…For comparison analysis, the cases were clustered according to the main underlying disease, e.g., homeopathy ( n = 79; Grauer et al, 1994 ; Higgins et al, 1994 ; Hsiao et al, 1994 ; Nasu et al, 1994 ; Hung et al, 1995 ; Spánik et al, 1995 ; Itoh et al, 1996 ; Fanci et al, 1997 ; Kataoka-Nishimura et al, 1998 ; Sklair-Levy et al, 1998 ; Krcmery et al, 1999 ; Takamura et al, 1999 ; Erer et al, 2000 ; Kim et al, 2001 ; Moretti-Branchini et al, 2001 ; Fournier et al, 2002 ; Hadley et al, 2002 ; Meyer et al, 2002 ; Chang et al, 2003 ; Marty et al, 2003 ; Bassetti et al, 2004 ; Chowdhary et al, 2004 ; Viscomi et al, 2004 ; Antachopoulos et al, 2005 ; Chan-Tack, 2005 ; Akagi et al, 2006 ; Ghiasian et al, 2006 ; Kendirli et al, 2006 ; Koyanagi et al, 2006 ; Matsue et al, 2006 ; Meguro-Hashimoto et al, 2006 ; Rodrigues et al, 2006 ; Hara et al, 2007 ; Miura et al, 2007 ; Rieger et al, 2007 ; Bayramoglu et al, 2008 ; Hosoki et al, 2008 ; Thibeault et al, 2008 ; Tsuji et al, 2008 ; Fekkar et al, 2009 ; Walia et al, 2009 ; Gabriel et al, 2011 ; Kudo et al, 2011 ; Hosokawa et al, 2012 ; Menezes et al, 2012 ; Chen et al, 2014 ; Issarachaikul et al, 2014 ; Karapinar et al, 2014 ; Capoor et al, 2015 ; Odero et al, 2015 ; Pérard et al, 2015 ; Tanyildiz et al, 2015 ), other immunodeficiency conditions ( n = 41; Canales et al, 1998 ; Lascaux et al, 1998 ; Anuradha et al, 2000 ; Piwoz et al,…”

Trichosporon mucoides fungemia in a liver transplant recipient: case report and review

“…Optimal therapy for invasive trichosporonosis is undefined and sparse data are available. Several antifungal agents, such as amphotericin B, fluconazole, and voriconazole, have been used either as monotherapy or in combination (3–14, 17–21, 23–27). Echinocandins do not seem to have activity against these yeasts and reports of breakthrough infections in patients receiving caspofungin or micafungin have emerged (7, 8, 18, 30, 31, 33, 34).…”

“…Trichosporon species are basiodiomycetous yeasts that predominantly cause superficial skin infections and scalp or pubic white piedra, but that can also cause invasive disease in immunocompromised individuals, especially those with hematological malignancies, profound neutropenia, or previous hematologic transplant (1–15). Trichosporonosis appears to be less common in other immunosuppressed states such as solid organ transplant recipients or in acquired immunodeficiency syndrome (16–22).…”

Acute Complete Splenic Infarction in a Patient with Hirschsprung’s Disease and Literature Review of Complete Splenic Infarction

“…commonly seen in sickle cell disease, but there are also reports in systemic lupus erythematosus in about 5% [9,10] , after bone marrow transplantation [11] and Rothmann-Makai syndrome (lipogranulomatosis subcutanea) [12] . Viscomi et al [13] described massive splenic infarction due to Trichosporon beigelii infiltration of the spleen. Another interesting complete splenic infarction was described in a patient with paroxysmal nocturnal hemoglobinuria due to thrombi in splenic veins by Tsatalas et al [14] .…”