Fatal Malignant Melanoma Associated With a Completely Regressed Primary Melanoma in a Patient With Cutaneous T-Cell Lymphoma

Mycosis fungoides associated with malignant melanoma and dysplastic nevus syndrome

“…In four of our cases (cases 1, 3, 4 and 5) and in two previously reported cases, 3,4 malignant melanoma was diagnosed before or at the time of MF diagnosis, although in some cases a history of an undiagnosed rash preceded the diagnosis of melanoma (case 3). It is unlikely that altered cellular immunity secondary to MF alone explains the association between MF and malignant melanoma in these patients.…”

“…Melanoma has also been reported in association with untreated MF 3 as well as with an undiagnosed rash (case 3) or premycotic condition such as poikiloderma vasculare atrophicans 4 which would later be diagnosed as MF. Carcinogenic or immunosuppressive effects of MF therapy cannot completely account for the development of melanoma in these patients.…”

Malignant Melanoma and Other Second Cutaneous Malignancies in Cutaneous T-Cell Lymphoma

“…23,30 Curative therapy for CTCL should not be withheld to pre¬ vent the occurrence of second skin cancers. However, the choice of additional, adjuvant or maintenance therapies may be modified to decrease the risk of second cutane¬ ous malignancies, especially in high-risk patients.…”

Cutaneous Malignant Melanoma Appearing during Photochemotherapy of Mycosis fungoides

“…Alteration of the immune response in this disease might favor the develop ment of second malignancies, perhaps including malignant melanoma. Nevertheless, only a few cases of malignant melanoma associated with mycosis fungoides or cutaneous T cell lymphoma have been reported [6][7][8], There is some evidence, including case reports, indicative of an increased frequency of malignant melanoma in situations that involve immunosuppression: renal-transplant recipients [9], HIVinfected patients [ 10-15J, neoplastic subjects 116],…”