2006
DOI: 10.1016/j.ijrobp.2006.03.012
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Fatal pneumonitis associated with intensity-modulated radiation therapy for mesothelioma

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Cited by 328 publications
(226 citation statements)
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“…Modern conformal radiation technologies, such as IMRT, open new possibilities in the treatment of complex‐shaped targets like MPM. However, Allen et al (11) point out how essential the reduction of mean lung dose in the radiotherapy of MPM is with severe pneumonitis seen after a mean dose of 15 Gy. Sterzing et al (12) compared tomotherapy and IMRT plans, and reported that, regarding the PTV, the biggest differences in plan comparison were seen in target coverage homogeneity.…”
Section: Discussionmentioning
confidence: 99%
“…Modern conformal radiation technologies, such as IMRT, open new possibilities in the treatment of complex‐shaped targets like MPM. However, Allen et al (11) point out how essential the reduction of mean lung dose in the radiotherapy of MPM is with severe pneumonitis seen after a mean dose of 15 Gy. Sterzing et al (12) compared tomotherapy and IMRT plans, and reported that, regarding the PTV, the biggest differences in plan comparison were seen in target coverage homogeneity.…”
Section: Discussionmentioning
confidence: 99%
“…Harvard reported that in patients treated after EPP with IMRT, there was a 46% rate of grade 5 (fatal) RP (8). Subsequently, there were concerns about the use of IMRT after pneumonectomy.…”
Section: Radiation After Eppmentioning
confidence: 99%
“…The combined use of postoperative IMRT and EPP has been suggested to improve overall survival and reduce recurrence. Recently, it has been reported that standard-dose IMRT after EPP and adjuvant chemotherapy resulted in a high rate (46%) of fatal pneumonitis [38]. Thereafter, a new system for calculating thoracic IMRT doses was established in the MD Anderson Cancer Center [39].…”
Section: Radiotherapy For Malignant Pleural Mesotheliomamentioning
confidence: 99%