Fatal Pulmonary Failure Attributable to Viral Pneumonia With Human Herpes Virus 6 (HHV6) in a Young Immunocompetent Woman

Merk, Johannes; Schmid, Franz X.; Schwarz, Stephan; Lehane, Cornelius; Boehm, Stephan; Salzberger, Bernd; Birnbaum, Dietrich E.

doi:10.1177/0885066605279068

Cited by 22 publications

(16 citation statements)

References 4 publications

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“…The radiological findings were described only as progressive bilateral interstitial infiltrates on chest radiographs. Meanwhile, Merk et al [9] reported fatal pulmonary failure in a healthy 19-year-old woman. The chest radiographs showed developing pulmonary infiltration at the basal region of both lungs, with large amounts of pulmonary effusions; however, no previous reports have published CT images.…”

Section: Discussionmentioning

confidence: 99%

A case of pneumonitis and encephalitis associated with human herpesvirus 6 (HHV-6) infection after bone marrow transplantation

Nakayama

Okada²,

Ando³

et al. 2010

BJR

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ABSTRACT. Human herpesvirus 6 (HHV-6)-associated encephalitis or pneumonitis has been reported in immunocompetent and immunosuppressed individuals. Several MRI studies in patients with HHV-6-associated encephalitis have been presented. However, to the best of our knowledge, no studies describing thin-section CT imaging in patients with HHV-6-associated pneumonitis have been reported. Here we describe a case of HHV-6-associated encephalitis and pneumonitis that developed after bone marrow transplantation. Thin-section CT images of the chest revealed ground-glass attenuation, consolidation and centrilobular nodules in both lungs.

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Section: Discussionmentioning

confidence: 99%

A case of pneumonitis and encephalitis associated with human herpesvirus 6 (HHV-6) infection after bone marrow transplantation

Nakayama

Okada²,

Ando³

et al. 2010

BJR

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“…Herpes simplex virus, cytomegalovirus, varicella-zoster virus, Epstein-Barr virus, human herpesvirus 6, and Kaposi's sarcoma-associated herpesvirus (KSHV) have all been associated with respiratory diseases (7,10,30,33,42,46). Much of our understanding of immune responses to viral infection of the respiratory tract comes from experimental animal models.…”

mentioning

confidence: 99%

Type I Interferon Inhibition and Dendritic Cell Activation during Gammaherpesvirus Respiratory Infection

Weslow-Schmidt

Jewell

Mertz

et al. 2007

J Virol

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The respiratory tract is a major mucosal site for microorganism entry into the body, and type I interferon (IFN) and dendritic cells constitute a first line of defense against viral infections. We have analyzed the interaction between a model DNA virus, plasmacytoid dendritic cells, and type I IFN during lung infection of mice. Our data show that murine gammaherpesvirus 68 (␥HV68) inhibits type I IFN secretion by dendritic cells and that plasmacytoid dendritic cells are necessary for conventional dendritic cell maturation in response to ␥HV68. Following ␥HV68 intranasal inoculation, the local and systemic IFN-␣/␤ response is below detectable levels, and plasmacytoid dendritic cells are activated and recruited into the lung with a tissue distribution that differs from that of conventional dendritic cells. Our results suggest that plasmacytoid dendritic cells and type I IFN have important but independent roles during the early response to a respiratory ␥HV68 infection. ␥HV68 infection inhibits type I IFN production by dendritic cells and is a poor inducer of IFN-␣/␤ in vivo, which may serve as an immune evasion strategy.Respiratory viral infections are the leading cause of acute illnesses worldwide, and several members of the herpesvirus family are responsible for severe pneumonia in neonates and immunocompromised patients (52). Herpes simplex virus, cytomegalovirus, varicella-zoster virus, Epstein-Barr virus, human herpesvirus 6, and Kaposi's sarcoma-associated herpesvirus (KSHV) have all been associated with respiratory diseases (7,10,30,33,42,46). Much of our understanding of immune responses to viral infection of the respiratory tract comes from experimental animal models. Murine gammaherpesvirus 68 (␥HV68) is structurally and biologically similar to the human gammaherpesviruses Epstein-Barr virus and KSHV (16,49,50), and it has become a useful in vivo model of herpesvirus infection. Intranasal infection of mice with ␥HV68 causes an acute respiratory infection that is rapidly resolved and followed by the establishment of splenic latency mainly in the B-cell compartment (16, 34). Analogous to KSHV (35,38,41), ␥HV68 also infects dendritic cells, a process that may act as a mechanism of immune evasion (18,20).Plasmacytoid dendritic cells are professional type I interferon (IFN)-producing cells that quickly respond to most viruses by secreting large amounts of type I IFNs (28). Type I IFN signaling is important for the control of acute ␥HV68 infection (17, 51). In addition, plasmacytoid dendritic cells secrete cytokines and interact with conventional dendritic cells and T cells (28) and are critical for the defense against parenteral and mucosal infections (1,13,25,29). Although plasmacytoid dendritic cells have been detected in the lungs (12,14) and have been shown to prevent the development of allergic asthma, we have limited information regarding their role in the antiviral response of the respiratory tract. This is of special importance because the lung is the largest epithelial surface in the body and constit...

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“…Los microorganismos que se han asociado a hipoxemia severa y progresión a SDRA son el virus sincicial respiratorio, el infl uenza A H1N1 pandémica, Pneumocystis jirovecii, VHS-1, virus del herpes simplex tipo 6, virus de Epstein Barr, virus infl uenza A H5N1, Chlamydia pneumoniae y metaneumovirus humano, entre otros [16][17][18][19] . El diagnóstico de trabajo del caso reportado, fue una neumonía grave con hipoxemia severa y progresión a SDRA; aunque los estudios microbiológicos y serológicos fueron negativos para detectar el agente etiológico, la prescripción de los antibióticos empíricos obedeció probablemente a la rápida progresión y severidad del cuadro clínico, la no detección del agente etiológico y la pobre respuesta, en las primeras 24 a 48 horas, de los tratamientos instaurados.…”

Section: Discussionunclassified

Neumonía fatal en una niña inmunocompetente, asociada a herpes simple tipo 1

et al. 2011

Rev. chil. pediatr.

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Fatal Pulmonary Failure Attributable to Viral Pneumonia With Human Herpes Virus 6 (HHV6) in a Young Immunocompetent Woman

Cited by 22 publications

References 4 publications

A case of pneumonitis and encephalitis associated with human herpesvirus 6 (HHV-6) infection after bone marrow transplantation

A case of pneumonitis and encephalitis associated with human herpesvirus 6 (HHV-6) infection after bone marrow transplantation

Type I Interferon Inhibition and Dendritic Cell Activation during Gammaherpesvirus Respiratory Infection

Neumonía fatal en una niña inmunocompetente, asociada a herpes simple tipo 1

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