Fatigue and correlation with disease-specific variables, spinal mobility measures, and health-related quality of life in ankylosing spondylitis

Alkan, Berat Meryem; Fidan, Fatma; Erten, Şükran; Aksekili, Hatice; Alemdar, Ayşenur; Eroğlu, Esra; Ardıçoğlu, Özge

doi:10.1007/s10165-012-0800-0

Cited by 13 publications

(11 citation statements)

References 15 publications

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“…Previous studies have shown that patients with ax-SpA report HRQOL scores that are similar to those reported for other inflammatory diseases [2,10], but lower than those in healthy controls [1,4,[11][12][13]. Women with the ax-SpA report lower HRQOL than men [14][15][16], and decreased HRQOL in patients with ax-SpA is associated with fatigue [17], increased disease activity, decreased daily activity and exercise [4,[18][19][20], pain, and adverse psychological factors such as body-image disturbance, anxiety and depression [21,22]. In the new millennium, effective new treatments have become available for Ax-SpA [e.g.…”

mentioning

confidence: 68%

“…Multivariable linear regression analysis, backward procedure (p = 0.20), was used to examine the demographic and disease-related variables at baseline that were associated with changes in HRQOL (delta SF-6D, 15D, SF-36 PCS and SF-36 MCS scores). The independent variables in the multiple analyses were chosen based on univariate associations with one of the delta HRQOL values (p < 0.10), clinical experience and factors found to be associated with HRQOL in previous studies [17,22,39]. These factors also resonate with the wider theory within the field [24,40].…”

Section: Statistical Analysesmentioning

confidence: 99%

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No deterioration in health-related quality of life in patients with axial spondyloarthritis followed for 5 years in ordinary outpatient clinics in the biological treatment era

et al. 2019

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Background Axial spondyloarthritis (ax-SpA) causes pain, fatigue, stiffness, loss of physical function and impaired healthrelated quality of life (HRQOL). Aims The study aimed to explore the changes in HRQOL over 5 years in patients with ax-SpA and to identify baseline predictors associated with changes in HRQOL assessed using three HRQOL measures. Methods Demographic, disease, medication and HRQOL data were collected at baseline and at 5-year follow-up. HRQOL was assessed using SF-6D, 15D and SF-36. Analyses involved McNemar, independent paired t tests and multiple regression. Results In the 240 (women 31%, men 69%) ax-SpA patients assessed (mean age 46 years), measures reflecting disease activity decreased and co-morbidities increased, and more patients were treated with biologic drugs during follow-up. No deterioration in HRQOL was observed between baseline and 5-year follow-up; indeed, there was a significant increase in SF-6D and SF-36 PCS scores. Improvement in HRQOL measured by SF-6D was associated with younger age, higher education, low Bath Ankylosing Spondylitis (BAS) Activity Index (BASDAI), high BAS Patient Global Score and high C-reactive protein; improvement in SF-36 PCS was associated with younger age, higher education, low BASDAI and no use of biological treatment at baseline. Conclusion Our ax-SpA outpatient clinic patients, with more patients treated with biologic drugs during the 5-year followup, did not deteriorate in HRQOL. In fact, the physical dimension in HRQOL improved over the years, as did measures reflecting disease activity. Our study adds evidence to the importance of suppressing inflammation to maintain and improve HRQOL in ax-SpA patients.

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mentioning

confidence: 68%

Section: Statistical Analysesmentioning

confidence: 99%

No deterioration in health-related quality of life in patients with axial spondyloarthritis followed for 5 years in ordinary outpatient clinics in the biological treatment era

et al. 2019

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“…Multiple linear regression analysis (general linear model (GLM) in SPSS) was used to examine the adjusted association between demographic- and disease-related variables and HRQoL (SF-36-PCS, SF-36-MCS, 15D and SF-6D scores). The independent variables in the multiple analyses were chosen based on univariate associations with HRQoL, clinical experience and factors associated with HRQoL in previous studies [ 6 , 15 , 37 ]. In the final multivariate model, we included the demographic variables, disease activity (assessed by BASDAI and MASES scores), health status (assessed by HAQ, BASFI and BAS-G scores), damage (assessed by BASMI score), co-morbidity and treatment centre as independent variables.…”

Section: Methodsmentioning

confidence: 99%

“…However, patients with ax-SpA report lower HRQoL than do healthy controls [ 3 , 12 ], and women with the disease report a lower HRQoL than do men [ 2 , 13 , 14 ]. Decreased HRQoL in patients with ax-SpA is associated with fatigue [ 15 ], increased disease activity, decreased daily activity and exercise [ 16 – 18 ], pain, and adverse psychological factors such as body image disturbance, anxiety and depression [ 6 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

The relationship between demographic- and disease-related variables and health-related quality of life in patients with axial spondyloarthritis

Rohde

Berg

Prøven

et al. 2017

BMC Musculoskelet Disord

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BackgroundAxial spondyloarthritis (ax-SpA) is a chronic inflammatory disease of the spine causing pain, stiffness, loss in physical function, and fatigue. Therefore, the physical and psychological burden of having this chronic disease can reduce the quality of life. We aimed to explore the relationship between demographic- and disease-related variables and health-related quality of life (HRQoL) in patients with ax-SpA.MethodsDemographic- and disease-related, HRQoL-related and treatment data were collected. Disease measures included the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the BAS Functional Index (BASFI), the BAS Global (BAS-G) score, the Maastricht Ankylosing Spondylitis Enthesitis Score (MASES), the Health Assessment Questionnaire (HAQ) and co-morbidity. HRQoL was assessed using the SF-36 and the utility measures SF-6D and 15D. Variables associated with HRQoL were identified in unadjusted and adjusted analyses.ResultsWe examined 380 patients with ax-SpA (67% men) with a mean age of 46 years. Among them, 86% reported exercising >1 h per week. Mean values were as follows: BASDAI, 3.17; MASES, 3.19; BASFI, 2.71; BAS-G. 3.88; and HAQ, 0.56. The percentage of current users of NSAIDs was 44%, and of DMARDs 23%. In multivariate analyses, exercising 1–3 h per week (B = 2.73, p = 0.022) and exercising >3 h per week (B = 2.71, p = 0.020), lower HAQ scores (B = −4.61, p = 0.001), lower BASFI scores (B = −1.05, p = 0.010) and lower BAS-G scores (B = −0.91, p = 0.001) were independently associated with higher SF-36-PCS scores, whereas modest alcohol consumption (B = 4.63, p = 0.018) and a lower BAS-G score (B = −1.73, p < 0.001) were independently associated with higher SF-36-MCS scores. Exercising 1–3 h per week (B = 0.032, p = 0.004) and exercising >3 h per week (B = 0.036, p = 0.001), lower HAQ scores (B = −0.051, p < 0.001), lower BAS-G scores (B = −0.010, p < 0.001) and co-morbidity (B = −0.014, p = 0.004) were independently associated with higher 15D scores. Finally, exercising 1–3 h per week (B = 0.045, p = 0.001) and exercising > 3 h per week (B = 0.053, p < 0.001), lower HAQ scores (B = −0.054, p = 0.001) and lower BAS-G scores (B = −0.020, p < 0.001) were associated with higher SF-6D scores.ConclusionsIn patients with ax-SpA, a low level of physical activity, impaired physical function and impaired general well-being were independently and consistently associated with a decreased HRQoL across all applied measures.

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“…This in turn will result in loss of work productivity and increased socioeconomic burden (2,3). Studies have also shown that patients with axial SpA report a lower HRQoL than do healthy controls and this reduction in HRQoL is associated with fatigue, pain, increased disease activity, and decreased daily activity and exercise (7)(8)(9). In addition, a lower HRQoL in SpA patients is associated with adverse psychological outcomes and a higher prevalence of anxiety and depression (10,11).…”

Section: Introductionmentioning

confidence: 99%

Responsiveness of the EuroQoL 5-Dimension (EQ-5D) questionnaire in patients with spondyloarthritis

Tsang

Wong

Cheung

et al. 2020

Preprint

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Fatigue and correlation with disease-specific variables, spinal mobility measures, and health-related quality of life in ankylosing spondylitis

Abstract: Patients with AS defined significantly more fatigue when compared with healthy persons. MAF was related to clinical and functional status and HR-QoL of patients with AS. We assume that MAF can be used as a sensitive fatigue measure in patients with AS.

Cited by 13 publications

References 15 publications

No deterioration in health-related quality of life in patients with axial spondyloarthritis followed for 5 years in ordinary outpatient clinics in the biological treatment era

No deterioration in health-related quality of life in patients with axial spondyloarthritis followed for 5 years in ordinary outpatient clinics in the biological treatment era

The relationship between demographic- and disease-related variables and health-related quality of life in patients with axial spondyloarthritis

Responsiveness of the EuroQoL 5-Dimension (EQ-5D) questionnaire in patients with spondyloarthritis

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