Fatigue and Physical Activity Patterns in Children With Inflammatory Bowel Disease

Bevers, Nanja; Van de Vijver, Els; Hanssen, Adrienne; Aliu, Arta; Vande Velde, Saskia; Roelant, Ella; Rezazadeh Ardabili, Ashkan; Rosias, Philippe; Stapelbroek, Janneke; Maartens, Imke Bertrams; van de Feen, Cathelijne; Escher, Johanna; Oudshoorn, Annemarie; Teklenburg-Roord, Sarah; Vreugdenhil, Anita; Pierik, Marie; van Rheenen, Patrick

doi:10.1097/mpg.0000000000003905

Cited by 3 publications

(12 citation statements)

References 25 publications

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“…In the 14 included studies, five indices were utilized to measure fatigue: PROMIS‐pediatric, 19,21,22,36 PedsQL MFL, 24,33 IMPACT‐III 34 and KIDSCREEN‐7, 39 none of which were originally intended to solely measure fatigue in PIBD (Table 2). Two of the studies used an objective measures, SenseWearPro2 activity accelerometer, which measures physical activity 1 and the Actigraph wGT3X‐BT triaxial accelerometer 24 . The PROMIS‐pediatric (version 2.0) is a generic index with a stand‐alone fatigue domain but it is not disease‐specific for PIBD.…”

Section: Resultsmentioning

confidence: 99%

“…Only half of those with improved disease activity over time reported improvement in fatigue. The second study excluded children younger than 12 years 24 . They used the Z ‐scores data of the generic PedsQL TM , where fatigue was defined as >−2 standard deviations, reporting rate of 23% in a cohort of 104 PIBD patients 24 …”

Section: Resultsmentioning

confidence: 99%

“…In our updated search from 2017 to July 2023, 118 potential manuscripts were identified and nine were selected for full text review based on relevance of the abstract. Three of the nine were excluded: one did not report on fatigue, one was a randomized controlled trial (RCT) that reported data included in a separate publication with more details 19 and one was the aforementioned systematic review, resulting in six additional studies being retained, 3,5,20–24 in addition to the eight manuscripts identified as of 2017. Thus, 14 studies reporting on fatigue in PIBD were eventually included, of which the primary outcome was fatigue in 10 studies 3,5,20–27 .…”

Section: Resultsmentioning

confidence: 99%

“…Thus, 14 studies reporting on fatigue in PIBD were eventually included, of which the primary outcome was fatigue in 10 studies. 3,5,[20][21][22][23][24][25][26][27] Nine of the studies used PROs completed by patients, [19][20][21][22][25][26][27][28][29][30] while four used a combination of PRO and parent proxy-reported outcome 3,5,23,31 (Table 2). No study reported fatigue rates in children younger than 6 years of age.…”

Section: Literature Review In Childrenmentioning

confidence: 99%

“…The second study excluded children younger than 12 years. 24 They used the Z-scores data of the generic PedsQL TM , where fatigue was defined as >−2 standard deviations, reporting rate of 23% in a cohort of 104 PIBD patients. 24 Most of the 14 included studies demonstrated a positive correlation between fatigue and disease activity in both CD and UC.…”

Section: Literature Review In Childrenmentioning

confidence: 99%

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Fatigue in pediatric inflammatory bowel diseases: A systematic review and a single center experience

Turner,

Focht,

Orlanski‐Meyer

et al. 2023

J. pediatr. gastroenterol. nutr.

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ObjectivesWe aimed to review the literature on fatigue in pediatric inflammatory bowel diseases (PIBD), to explore how it is measured, and approximate its rate in an inception pediatric cohort.MethodsStudies on fatigue were systematically reviewed and selected by two authors. Next, we retrieved the two fatigue‐related questions of the IMPACT‐III questionnaire at 4 and 12 months after diagnosis from a prospectively maintained cohort of PIBD patients, each scoring 0‐100 (lower scores imply more fatigue), and 44 healthy controls.ResultsThe systematic review identified 14 studies reporting fatigue in children, of which nine had fatigue as the primary outcome and only two provided rates of fatigue. No standalone index was identified for measuring fatigue specifically for PIBD. Of 80 children included in the inception cohort, 62 (78%) scored an average of ≤75 on the two IMPACT‐III questions (approximating at least mild fatigue), 26 (33%) scored ≤50 (at least moderate fatigue) and nine (11%) scored ≤25 (severe fatigue). In comparison, only four (9%) healthy children scored at least moderate fatigue (p = 0.007). Fatigue rates at 12 months were only slightly and nonsignificantly lower. Fatigue of any severity was reported in 92% children with active disease versus 63% of those in clinical remission (p = 0.01).ConclusionLiterature reporting on fatigue in PIBD is scarce, and no PIBD‐specific tool is available to measure fatigue. In our cohort, fatigue‐related questions were frequently scored low in children with IBD, mainly among children with active disease but also during clinical remission.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Literature Review In Childrenmentioning

confidence: 99%

Section: Literature Review In Childrenmentioning

confidence: 99%

See 3 more Smart Citations

Fatigue in pediatric inflammatory bowel diseases: A systematic review and a single center experience

Turner,

Focht,

Orlanski‐Meyer

et al. 2023

J. pediatr. gastroenterol. nutr.

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Considerations in Paediatric and Adolescent Inflammatory Bowel Disease

Vuijk,

Camman,

de Ridder

2024

Journal of Crohn's and Colitis

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The incidence of inflammatory bowel disease [IBD] is rising most rapidly among children and adolescents. Paediatric-onset IBD is associated with a more extensive and severe disease course compared to adult-onset IBD. At a young age, screening for underlying genetic and immunological disorders is important and may impact treatment management. Early and effective treatment is crucial to reach disease remission and prevent complications of ongoing active disease. In children with Crohn’s disease, exclusive enteral nutrition is an effective induction therapy. Other promising dietary therapies, such as the Crohn’s disease exclusion diet, are emerging. Within paediatric IBD, anti-tumour necrosis factor therapy is the only approved biological thus far and additional treatment options are crucially needed. Other biological therapies, such as vedolizumab and ustekinumab, are currently prescribed off-label in this population. A specific challenge in paediatric IBD is the unacceptable and major delay in approval of drugs for children with IBD. A guided transfer period of paediatric patients to adult care is associated with improved disease outcomes and is required. Major knowledge gaps and challenges within paediatric IBD include the aetiology, diagnostics, and monitoring of disease, tailoring of treatment, and both understanding and coping with the physical and psychological consequences of living with IBD. Challenges and research gaps in paediatrics should be addressed without any delay in comparison with the adult field, in order to ensure a high quality of care for all patients with IBD, irrespective of the age of onset.

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Self-Compassion in Adolescents and Young Adults With Inflammatory Bowel Disease: Relationship of Self-Compassion to Psychosocial and Physical Outcomes

Neiman,

Boothroyd,

Anjur

et al. 2024

Inflammatory Bowel Diseases

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Background Adolescents and young adults (AYAs) diagnosed with inflammatory bowel disease (IBD) are at an increased risk for poor physical and mental health due to the complexity of pediatric onset IBD and the unique developmental challenges of this period of life. Self-compassion is increasingly recognized as having an important role in explaining health outcomes and well-being across a range of populations. This study examines the relationship between self-compassion and psychosocial and physical health outcomes in AYAs with IBD. Methods In this cross-sectional study, AYAs with IBD aged 15 to 25 years completed an online survey between February 2020 and October 2021. Questionnaires included the Self-Compassion Scale—Short Form, Patient-Reported Outcomes Measurement Information System (PROMIS) measures for psychosocial, physical and global health outcomes, and IBD disease activity indices. Results AYAs with higher levels of self-compassion were found to have better psychosocial (ie, anxiety, depressive symptoms, psychological stress, physical stress, peer relationships), physical (ie, fatigue), and global health outcomes. Self-compassion was a significant independent predictor of anxiety (β = −5.80, P = < .001), depressive symptoms (β = −7.09, P = < .001), psychological stress (β = −4.66, P = < .001), physical stress (β = −3.19, P = < .001), peer relationships (β = 3.39, P = .003), fatigue (β = −2.05, P = .019), and improved global health (β = 5.15, P = < .001). Conclusions This study offers preliminary support for the importance of self-compassion in AYAs with IBD and demonstrates the need for further research in this area.

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Fatigue and Physical Activity Patterns in Children With Inflammatory Bowel Disease

Cited by 3 publications

References 25 publications

Fatigue in pediatric inflammatory bowel diseases: A systematic review and a single center experience

Fatigue in pediatric inflammatory bowel diseases: A systematic review and a single center experience

Considerations in Paediatric and Adolescent Inflammatory Bowel Disease

Self-Compassion in Adolescents and Young Adults With Inflammatory Bowel Disease: Relationship of Self-Compassion to Psychosocial and Physical Outcomes

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