Objective: to analyze the quality of life of women with breast cancer undergoing chemotherapy. Methods: a cross-sectional study with 76 women. We used the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire-30 and Supplementary Questionnaire Breast Cancer Module. Results: there was a low correlation between socio-demographic and clinical variables with the quality of life domains. The best scores corresponded to women from 49 to 51 years old, married, dark-skinned, better schooling and formal work. The least mentioned symptoms were: Swollen breast (84.2%), Vomiting (81.6%); Shortness of breath (80.3%). Conclusion: general health presented satisfactory average, which suggests a good quality of life according to the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire-30. However, the Functional and Symptoms domains, as measured by Supplementary Questionnaire Breast Cancer Module, were negatively influenced by old age and larger cycles of chemotherapy. Descriptors: Breast Neoplasms; Quality of Life; Drug Therapy; Nursing Care. Objetivo: analisar a qualidade de vida de mulheres com câncer mamário submetidas à quimioterapia. Métodos: estudo transversal com 76 mulheres. Foram utilizados os European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire-30 e Supplementary Questionnaire Breast Cancer Module. Resultados: houve fraca correlação entre variáveis sociodemográficas e clínicas com domínios de Qualidade de Vida. Os melhores escores foram mulheres de 49 a 51 anos, casadas, pardas, melhor escolaridade e trabalho formal. Os sintomas menos referidos foram: Inchaço no seio doente (84,2%), Vômitos (81,6%); Falta de ar (80,3%). Conclusão: a saúde geral apresentou média considerada satisfatória, o que sugere boa qualidade de vida no European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire-30. Entretanto, os domínios Funcional e de Sintomas, medidos pelo questionário Supplementary Questionnaire Breast Cancer Module, foram negativamente influenciados pela idade avançada e maiores ciclos de quimioterapia. Descritores: Neoplasias da Mama; Qualidade de Vida; Tratamento Farmacológico; Cuidados de Enfermagem.