Fatty acid binding to serum albumin: Molecular simulation approaches

Fujiwara, Sayaka; Amisaki, Takashi

doi:10.1016/j.bbagen.2013.03.032

Cited by 78 publications

(63 citation statements)

References 153 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in this study, lipids were found to inhibit the accumulation of PFOS and PFOA in roots. It is reported that free fatty acids could affect the bindings between endogenous or exogenous compounds and proteins (Fujiwara and Amisaki, 2013;Spector et al, 1973). The inhibitory ability depends on the binding strength of the particular compound to proteins.…”

Section: Relationships Between the Contents Of Protein And Lipid And mentioning

confidence: 99%

The roles of protein and lipid in the accumulation and distribution of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in plants grown in biosolids-amended soils

Wen

Zhang

et al. 2016

Environmental Pollution

159

View full text Add to dashboard Cite

a b s t r a c tThe roles of protein and lipid in the accumulation and distribution of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in seven species of plants from biosolids-amended soils were investigated. The PFOS and PFOA root concentration factors (C root /C soil ) ranged from 1.37 to 4.68 and 1.69 to 10.3 (ng/g root )/(ng/g soil ), respectively, while the translocation factors (C shoot /C root ) ranged from 0.055 to 0.16 and 0.093 to 1.8 (ng/g shoot )/(ng/g root ), respectively. The PFOS and PFOA accumulations in roots correlated positively with root protein contents (P < 0.05), while negatively with root lipid contents (P < 0.05). These suggested the promotion effects of protein and inhibition effects of lipid on root uptake. The translocation factors correlated positively with the ratios between protein contents in shoots to those in roots (P < 0.05), showing the importance of protein on PFOS and PFOA translocation. This study is the first to reveal the different roles of protein and lipid in the accumulation and distribution of PFOS and PFOA in plants.

show abstract

Section: Relationships Between the Contents Of Protein And Lipid And mentioning

confidence: 99%

The roles of protein and lipid in the accumulation and distribution of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in plants grown in biosolids-amended soils

Wen

Zhang

et al. 2016

Environmental Pollution

159

View full text Add to dashboard Cite

show abstract

“…The effect of TE dose is more marked in trained than in sedentary rats, but unfortunately, the observed changes in fluorescence are not statistically significant, probably due to large inter-individual variability. The effect of testosterone dosage may be connected with modification of fluorescence of albumin, the protein involved in transport of serum endogenous steroids, as well as transport of fatty acids in the circulation [21]. Fig.…”

Section: Effect Of Endurance Training and Testosterone Treatment On Smentioning

confidence: 99%

Effect of Endurance Training and Testosterone Treatment on the Fluorescence Spectra of Rat Serum

et al. 2016

View full text Add to dashboard Cite

The paper presents an investigation into the effects of endurance training and testosterone enanthate (TE) treatment on rat blood serum by fluorescence spectroscopy. Blood serum was collected from adolescent male Wistar rats randomized between the untrained controls and trained animals, either steroid untreated or receiving I.M. injections (8 or 80 mg/kgBW) of testosterone enanthate. Fluorescence measurements were performed for undiluted or 20-and 500-fold diluted serum and analysed separately in the ultraviolet and visible light regions. In both regions the impact of the TE administration was more pronounced than the effect of endurance training. Moreover, in the visible region of spectrum, originated from a number of fluorescent metabolites, the influence of studied factors was more noticeable. The opposite effect of endurance training and administration of TE on serum emission was found for a lower (8 mg/kgBW) dose of testosterone, whereas a high-dose TE (80 mg/kgBW) treatment resulted in a return of fluorescence intensity.

show abstract

“…Unfortunately, microscopic details concerning the dynamics of the lipid binding are currently not easily accessible to the experiment. Molecular dynamics (MD) 1 represents an interesting tool to tackle this issue [13,14] and has already been successfully employed in a few cases [15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Fatty acid binding into the highest affinity site of human serum albumin observed in molecular dynamics simulation

Rizzuti

Bartucci

Sportelli

et al. 2015

Archives of Biochemistry and Biophysics

View full text Add to dashboard Cite

Fatty acid binding to serum albumin: Molecular simulation approaches

Abstract: Molecular simulation approaches have great potentials to provide detailed biophysical insights into HSA as well as the effects of the binding of FAs or other ligands to HSA. This article is part of a Special Issue entitled Serum Albumin.

Cited by 78 publications

References 153 publications

The roles of protein and lipid in the accumulation and distribution of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in plants grown in biosolids-amended soils

The roles of protein and lipid in the accumulation and distribution of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in plants grown in biosolids-amended soils

Effect of Endurance Training and Testosterone Treatment on the Fluorescence Spectra of Rat Serum

Fatty acid binding into the highest affinity site of human serum albumin observed in molecular dynamics simulation

Contact Info

Product

Resources

About