Fatty Acid Composition and Eicosanoid Levels (LTE<sub>4</sub>and PGE<sub>2</sub>) of Human Milk from Normal Weight and Overweight Mothers

García-Ravelo, Sara; Díaz-Gómez, N. Marta; Martín, M.V.; Dorta‐Guerra, Roberto; Murray, M; Escuder, Diana; Rodrı́guez, Covadonga

doi:10.1089/bfm.2017.0214

Cited by 21 publications

(15 citation statements)

References 47 publications

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“…In a similar article,n-3 LCPUFA (including EPA and DHA) were lower while n-6 LCPUFA and n-6/n-3 ratio were higher in overweight mothers at 6-7 months of lactation (20).…”

Section: Lipidsmentioning

confidence: 73%

“…Lipid composition of BM seems influenced by maternal BMI, influencing its inflammatory and oxidative profile (20).…”

Section: Lipidsmentioning

confidence: 99%

“…(96,(21)(22)(23)(24). LCFAs are less digestible by the neonatal gut; moreover, long-chain polyunsaturated fatty acids (LCPUFAs), such as eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA) are involved in several metabolic pathways, including a role as constituents of cells membranes, and in nervous system and retina development (20).…”

Section: Lipidsmentioning

confidence: 99%

“…Oleic acid was shown to reduce obesity risk and improve the metabolic and lipid profiles in adults (98). DGLA, other n-6 PUFAs such as AA, and bosseopentaenoic acid (20:5 n-6) are probably involved in the pathogenesis of obesity, promoting adipogenesis and inflammation (20). This group correlates with a greater increase in the weight for age (WFA) z-score, a smaller increase in the lengh for age z-score and of the CC between 2 weeks and 2 months of age.…”

Section: Lipidsmentioning

confidence: 99%

“…As result, we found and discussed a single article on untargeted metabolomics (15), a total of four articles on targeted metabolomics (16)(17)(18)(19), and 10 articles on lipidomics (20)(21)(22)(23)(24)(25)(26)(27)(28)(29) published since 2013-2020. Review articles were excluded.…”

Section: Introductionmentioning

confidence: 99%

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The Human Breast Milk Metabolome in Overweight and Obese Mothers

et al. 2020

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Pre-pregnancy body mass index (BMI) is a major relevance factor, since maternal overweight and obesity can impair the pregnancy outcome and represent risk factors for several neonatal, childhood, and adult conditions, including excessive weight gain, cardiovascular disease, diabetes mellitus, and even behavioral disorders. Currently, breast milk (BM) composition in such category of mothers was not completely defined. In this field, metabolomics represents the ideal technology, able to detect the whole profile of low molecular weight molecules in BM. Limited information is available on human BM metabolites differences in overweight or obese compared to lean mothers. Analyzing all the metabolomics studies published on Medline in English language, this review evaluated the effects that 8 specific types of metabolites found altered by maternal overweight and obesity (nucleotide derivatives, 5-methylthioadenosine, sugar-alcohols, acylcarnitine and amino acids, polyamines, mono-and oligosaccharides, lipids) can exert on the risk of offspring obesity development and other potentially associated health outcomes and complications. However, metabolites variations in samples collected from overweight and obese mothers and the potentially correlated effects highlighted below still need further investigations and should be confirmed in future metabolomics studies on larger samples. Finally, the positive or negative influence of maternal overweight and obesity on the offspring, potentially exerted by breastfeeding, should be analyzed in close correlation with maternal age, genetic and environmental factors, including diet, and taking into account the interactions occurring between BM metabolites and lactobiome. The evaluation of all the factors affecting BM metabolites in overweight and obese mothers can lead to the comprehensive description of such biofluid and the related effects on breastfed subjects, potentially highlighting personalized needs of BM supplementation or short-and long-term prevention strategies to optimize offspring health.

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“…In a similar article,n-3 LCPUFA (including EPA and DHA) were lower while n-6 LCPUFA and n-6/n-3 ratio were higher in overweight mothers at 6-7 months of lactation (20).…”

Section: Lipidsmentioning

confidence: 73%

“…Lipid composition of BM seems influenced by maternal BMI, influencing its inflammatory and oxidative profile (20).…”

Section: Lipidsmentioning

confidence: 99%