Fatty acid composition, enzyme inhibitory effect, antioxidant and anticancer activity of extract from Saponaria prostrata WILLD. subsp. anatolica HEDGE

Erdoğan, Mehmet Kadir; Geçibesler, İbrahim Halil; Yapar, Yakup; Gündoğdu, Ramazan; Kırıcı, Mahinur; Behçet, Lütfi; Taslimi, Parham

doi:10.1016/j.bioorg.2021.105032

Cited by 15 publications

(6 citation statements)

References 52 publications

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“…Mihaylova et al [70] have concluded that even low-containing polyphenolic fractions exhibit an effect on AChE, which is in concordance with our finding and can be explained by the positive effect of BAO on the inhibitory activity of acetylcholinesterase despite their low content of polyphenols and flavonoids. In the present study, concerning the GC-MS content analysis, it might be considered that oleic, linoleic, palmitoleic, and other fatty acids identified in BAO could have an inhibitory effect on AChE [53].…”

Section: Anticholinesterase Inhibitory Activitymentioning

confidence: 84%

“…In this regard, the tested oil could be regarded as a good source of this acid. Potential health benefits attributed to linoleic acid include cardioprotective effects, modulation of the inflammatory response, and a positive effect on both central nervous system function and behavior [53]. Considering the valuable fatty acid content found in BAO, it could be suggested as a dietary agent for providing these fatty acids to the human body.…”

Section: Fatty Acid Compositionmentioning

confidence: 99%

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Prunus amygdalus var. amara (bitter almond) seed oil: fatty acid composition, physicochemical parameters, enzyme inhibitory activity, antioxidant and anti-inflammatory potential

et al. 2022

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Oil seeds are a natural source of phytochemicals with high nutritional value. The present study aims to evaluate for the first time the antioxidant, enzyme inhibitory, and anti-inflammatory activities in vitro and in vivo, as well as the physicochemical properties, fatty acid compositions, total polyphenol, flavonoid, and tocopherol contents of Algerian Prunus amygdalus var. amara cold-pressed oil. Bitter almond produces seeds that yield 35.5% of oil. It was characterized by a high saponification index of 215.94 mg KOH g −1 of oil, a peroxide value of 7.74 meq O 2 kg of oil, a K 232 of 2.612, and a K 270 of 0.39. This oil represented a valuable source of healthy fatty acids. GC-MS analysis revealed oleic (68.27%) and linoleic (16.14%) as the main fatty acids. α-Tocopherol (85.77 mg/kg) was found to be the major component. The total phenolic and flavonoid contents were 21.94 ± 0.29 and 21.52 ± 0.14 µg/mL, respectively. The oil showed good antioxidant activity (A 0.50 = 34 ± 0.44 μg/ mL) using the CUPRAC assay and modest activity with DPPH, ABTS, FRAP, and β-carotene assays, respectively. BAO (bitter almond oil) displayed the most promising α-glucosidase and α-amylase activities compared to acarbose as a reference molecule and moderate acetylcholinesterase (AChE) inhibitory activity. Moreover, BAO demonstrated in vitro and in vivo anti-inflammatory efficacy in a dose-dependent manner, comparable to that of diclofenac sodium. These effects were confirmed by histological examinations. Overall, our results showed that BAO has a strong potential to design new industrial preparations with nutritional, pharmaceutical, and cosmeceutical applications.

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Section: Anticholinesterase Inhibitory Activitymentioning

confidence: 84%

Section: Fatty Acid Compositionmentioning

confidence: 99%

Prunus amygdalus var. amara (bitter almond) seed oil: fatty acid composition, physicochemical parameters, enzyme inhibitory activity, antioxidant and anti-inflammatory potential

et al. 2022

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“…When these results were compared with some medicinal plant extracts in the literature, it was seen that H. linarioides extracts show similar inhibitory activity on AChE with close IC 50 values. [79]…”

Section: Enzyme Activityα-glycosidase and Acetylcholinesterase Resultsmentioning

confidence: 99%

Phytochemical Analysis and Biological Evaluation of Hypericum linarioides Bosse: in Vitro and in Silico Studies

et al. 2022

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The aim of this study is to determine the phenolic composition of Hypericum linarioides Bosse, to assess its various biological properties, and finally to confirm the experimental data of enzyme inhibitions via docking studies. LC-MS/MS analysis performed over methanol extract (ME) revealed the presence of 27 phytochemicals. Antioxidant activity results indicated that ME had the strongest DPPH radical scavenging and ferric ion reducing capacity than water and hexane extracts. XTT assays revealed the strongest anti-proliferative activity of ME against MCF-7 and HT-29 cancer cells. Flow cytometry results also confirmed the notable apoptotic effect of ME on MCF-7 cells through mitochondria-dependent pathway. Enzyme activity results exhibited the most promising acetylcholinesterase and α-glycosidase inhibitory activities of the ME. Molecular docking calculations of α-glycosidase with the major compounds (1, 15, 17 and 19) indicated that 17 (isoquercitrin) had the best docking binding energy (À 10.92 kcal/mol) with appropriate binding interactions.

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“…4-hydroxyphenylethyl group 1a-e was determined according to the reported method by Tao et al [78] and this method was based on previous studies. [79,80] The absorbance was spectrophotometrically measured at 405 nm.…”

Section: Synthesis Of Dibromo{1-[(4-hydroxyphenyl)mentioning

confidence: 99%

New PEPPSI‐Pd‐NHC complexes bearing 4‐hydroxyphenylethyl group: Synthesis, characterization, molecular docking, and bioactivity properties

Behçet

Taslimi

Gök

et al. 2022

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Five 4‐hydroxyphenylethyl substituted pyridine enhanced, precatalyst, preparation, stabilization, and initiation‐Pd‐N‐heterocyclic carbene (PEPPSI‐Pd‐NHC) complexes are synthesized in a straightforward way. All PEPPSI‐Pd‐NHC complexes were prepared by mixing 4‐hydroxyphenylethyl substituted NHC precursors, palladium chloride, potassium carbonate, and potassium bromide in pyridine. All complexes were screened for human carbonic anhydrase I (hCA I) and hCA II, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α‐glucosidase (α‐Glu) inhibitory activities. The ChE inhibitory activities of the new PEPPSI‐Pd‐NHC complexes bearing the 4‐hydroxyphenylethyl group (1a–e) against α‐Glu, AChE, and BChE were determined by the Tao and Ellman methods. The results indicated that all the synthetic complexes exhibited potent inhibitory activities against all targets as compared to the standard inhibitors, revealed by IC50 values. The Ki values of the new PEPPSI‐Pd‐NHC complexes 1a–e for hCA I, hCA II, AChE, BChE, and α‐Glu were obtained in the ranges of 18.98–32.65, 22.95–38.13, 3.67–11.65, 4.09–9.36, 186.92–287.45 µM, respectively. Among the synthesized complexes, the most potent complexes were 1c toward hCA I and II with Ki values 18.98 and 22.95 µM, and 1d toward AChE and BChE with Ki = 3.67 and 4.09 µM, respectively.

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Fatty acid composition, enzyme inhibitory effect, antioxidant and anticancer activity of extract from Saponaria prostrata WILLD. subsp. anatolica HEDGE

Cited by 15 publications

References 52 publications

Prunus amygdalus var. amara (bitter almond) seed oil: fatty acid composition, physicochemical parameters, enzyme inhibitory activity, antioxidant and anti-inflammatory potential

Prunus amygdalus var. amara (bitter almond) seed oil: fatty acid composition, physicochemical parameters, enzyme inhibitory activity, antioxidant and anti-inflammatory potential

Phytochemical Analysis and Biological Evaluation of Hypericum linarioides Bosse: in Vitro and in Silico Studies

New PEPPSI‐Pd‐NHC complexes bearing 4‐hydroxyphenylethyl group: Synthesis, characterization, molecular docking, and bioactivity properties

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