Fatty acid positional distribution (<i>sn</i>-2 fatty acids) and phospholipid composition in Chinese breast milk from colostrum to mature stage

Wu, Ke; Gao, Rui; Tian, Fang; Mao, Yingyi; Wang, Bei; Zhou, Lili; Shen, Lianju; Guan, Ying; Cai, Meiqin

doi:10.1017/s0007114518002994

Cited by 46 publications

(29 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The fatty acid methyl ethers were then separated in a capillary column (Supelco 2560, 100 m × 0•25 mm × 0•20 μm; Sigma-Aldrich) and quantified by Agilent 7890B GC with flame ionisation detector (Agilent Tech.) (26) . The carrier gas was He with a flow rate of 0•8 ml/min and a split ratio of 1:20.…”

Section: Fatty Acid Analysismentioning

confidence: 99%

Lactational changes of fatty acids and fat-soluble antioxidants in human milk from healthy Chinese mothers

Zhu

Zhou

et al. 2020

Br J Nutr

Self Cite

View full text Add to dashboard Cite

Human milk fat is specially tailored to supply the developing infant with adequate and balanced nutrients. The present study aimed to quantify the composition of fatty acids, tocopherols and carotenoids in human milk, with special emphasis on the lactational changes. Colostrum, transitional and mature milk samples were collected longitudinally from the same forty-two healthy, well-nourished Chinese mothers. Fatty acids were quantified by GC with carotenoids (carotenes and xanthophylls) and tocopherols (α-, γ-tocopherol) determined by HPLC. Total fatty acid (TFA) content increased from 15·09 g/l in colostrum to 32·57 g/l in mature milk with the percentages of DHA and arachidonic acid (ARA) decreased. The ratio of n-6:n-3 PUFA and ARA:DHA remained constant during lactation at about 11:1 and 1·3:1, respectively. Both α-tocopherol and γ-tocopherol decreased over lactation with the ratio of α-:γ-tocopherol declined significantly from 7·21:1 to 4·21:1 (P < 0·001). Carotenoids all dropped from colostrum to mature milk as the less polar carotenes dropped by 88·67 %, while xanthophylls only dropped by 35·92 %. Lutein was predominated in both transitional and mature milk carotenoids (51·64–52·49 %), while colostrum carotenoids were mainly composed of lycopene (32·83 %) and β-carotene (30·78 %). The concentrations of tocopherols and xanthophylls but not carotenes were positively associated with TFA content in milk. These results suggested that colostrum and mature milk contained divergent lipid profiles and selective transfer mechanisms related to polarity might be involved. The present outcomes provide new insights for future breast-feeding studies, which also add in scientific evidences for the design of both initial and follow-on infant formulas.

show abstract

Section: Fatty Acid Analysismentioning

confidence: 99%

Lactational changes of fatty acids and fat-soluble antioxidants in human milk from healthy Chinese mothers

Zhu

Zhou

et al. 2020

Br J Nutr

Self Cite

View full text Add to dashboard Cite

show abstract

“…After birth, infants continue to obtain NA from human milk. Several publications have indicated that the NA concentration in human milk markedly decreases as lactation stages progress [10,11,12]. NA concentrations in colostrum (≤1 week postpartum) have been found to range from two- to six-fold higher than those in mature milk (>2 weeks and ≤16 weeks) [13,14].…”

Section: Introductionmentioning

confidence: 99%

Quantification of Nervonic Acid in Human Milk in the First 30 Days of Lactation: Influence of Lactation Stages and Comparison with Infant Formulae

Yuan

Zhang

et al. 2019

Nutrients

View full text Add to dashboard Cite

Nervonic acid (24:1 n-9, NA) plays a crucial role in the development of white matter, and it occurs naturally in human milk. This study aims to quantify NA in human milk at different lactation stages and compare it with the NA measured in infant formulae. With this information, optimal nutritional interventions for infants, especially newborns, can be determined. In this study, an absolute detection method that uses experimentally derived standard curves and methyl tricosanoate as the internal standard was developed to quantitively analyze NA concentration. The method was applied to the analysis of 224 human milk samples, which were collected over a period of 3–30 days postpartum from eight healthy Chinese mothers. The results show that the NA concentration was highest in colostrum (0.76 ± 0.23 mg/g fat) and significantly decreased (p < 0.001) in mature milk (0.20 ± 0.03 mg/g fat). During the first 10 days of lactation, the change in NA concentration was the most pronounced, decreasing by about 65%. Next, the NA contents in 181 commercial infant formulae from the Chinese market were compared. The NA content in most formulae was <16% of that found in colostrum and less than that found in mature human milk (p < 0.05). No significant difference (p > 0.05) was observed among NA content in formulae with different fat sources. Special attention was given to the variety of n-9 fatty acids in human milk during lactation, and the results indicated that interindividual variation in NA content may be primarily due to endogenous factors, with less influence from the maternal diet.

show abstract

“…Lingkar kepala bayi pada penelitian ini dikategorikan berdasarkan Kemenkes 25 dimana sebagian besar bayi (89,9%) memiliki ukuran lingkar kepala normal (Tabel 1). Rata-rata ukuran lingkar kepala bayi pada penelitian adalah 34,35 ± 1,41 cm yang tidak jauh berbeda dengan lingkar kepala bayi di Cina (34,5 ± 1 cm) 39 , India (34,5 ± 1,8 cm) 40 , dan Jepang (34,0 ± 2 cm) 41 .…”

Section: Hasil Dan Pembahasanunclassified

Hubungan antara Asupan Asam Lemak Tidak Jenuh Ganda pada Ibu Menyusui, Kandungannya dalam ASI dan Lingkar Kepala Bayi: Studi pada Periode Awal Postpartum

Syahadah¹,

Dewi²,

Rimbawan³

2021

AMNT

View full text Add to dashboard Cite

Latar Belakang: Tercukupinya kebutuhan akan asupan asam lemak tidak jenuh ganda (polyunsaturated fatty acids, PUFA) dan status gizi ibu hamil yang optimal diketahui memiliki peran penting dalam mendukung pertumbuhan dan perkembangan otak janin dan bayi. Studi menunjukkan bahwa asupan PUFA ibu hamil di beberapa daerah di Indonesia sangat rendah dan juga masih banyak ibu hamil yang memiliki status gizi kurang. Kedua masalah gizi pada ibu hamil tersebut diduga berpengaruh terhadap pertumbuhan otak janin yang dalam penelitian ini diestimasi dengan ukuran lingkar kepala.Tujuan: Penelitian ini bertujuan menganalisis hubungan asupan PUFA ibu hamil dan status gizi pra-hamil dengan lingkar kepala bayi baru lahir.Metode: Analisis data sekunder menggunakan data hasil penelitian hibah BASF South East Asia yang telah dilakukan pada bulan April-Oktober tahun 2018 di Kota Bogor oleh tim SEAFAST CENTER IPB. Subyek merupakan ibu hamil dengan usia kehamilan trimester 3 dan merupakan kehamilan tunggal. Total terdapat 79 data ibu dan bayinya yang meliputi data asupan PUFA saat hamil, lingkar kepala bayi, karakteristik ibu, kondisi sosial-ekonomi ibu, dan IMT pra-hamil. Analisis data dilakukan menggunakan uji korelasi Spearman.Hasil: Rata-rata asupan PUFA ibu saat hamil tergolong rendah (< 80% tingkat kecukupan) serta belum memenuhi rekomendasi asupan PUFA. Asupan PUFA ibu saat hamil berhubungan positif dengan lingkar kepala bayi namun tidak signifikan (p > 0,05). Lingkar kepala bayi secara signifikan memiliki hubungan positif dengan IMT pra-hamil (p = 0,010).Kesimpulan: Lingkar kepala bayi pada penelitian ini tidak memiliki hubungan signifikan dengan asupan PUFA ibu saat hamil, namun berhubungan signifikan dengan IMT pra-hamil.

show abstract

Fatty acid positional distribution (sn-2 fatty acids) and phospholipid composition in Chinese breast milk from colostrum to mature stage

Cited by 46 publications

References 42 publications

Lactational changes of fatty acids and fat-soluble antioxidants in human milk from healthy Chinese mothers

Lactational changes of fatty acids and fat-soluble antioxidants in human milk from healthy Chinese mothers

Quantification of Nervonic Acid in Human Milk in the First 30 Days of Lactation: Influence of Lactation Stages and Comparison with Infant Formulae

Hubungan antara Asupan Asam Lemak Tidak Jenuh Ganda pada Ibu Menyusui, Kandungannya dalam ASI dan Lingkar Kepala Bayi: Studi pada Periode Awal Postpartum

Contact Info

Product

Resources

About