Fatty acid profile of stinging nettle leaves: application of modern analytical procedures for sample preparation and analysis

Đurović, Saša; Zeković, Zoran; Šorgić, Saša; Popov, Saša; Vujanović, Milena; Radojković, Marija

doi:10.1039/c7ay02559a

Cited by 20 publications

(11 citation statements)

References 19 publications

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“…Although, the polyunsaturated fatty acids (PUFAs)/saturated fatty acids ratio was reported to be comparably contained, among PUFAs, fatty acids of n-3 and n-6 series were more abundant than monounsaturated fatty acids. This finding was in contrast with a recent investigation regarding fatty acids in U. dioica leaves which analyzed a rapid solid–liquid extraction (Soxtherm) using petroleum ether as the solvent, revealing a favorable outcome for saturated acids compared to unsaturated acids [11]. Among monounsaturated fatty acids, a small amount of C17:1 fatty acid was detected (0.13%).…”

Section: Introductioncontrasting

confidence: 84%

Therapeutic Perspectives of Molecules from Urtica dioica Extracts for Cancer Treatment

et al. 2019

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A large range of chronic and degenerative diseases can be prevented through the use of food products and food bioactives. This study reports the health benefits and biological activities of the Urtica dioica (U. dioica) edible plant, with particular focus on its cancer chemopreventive potential. Numerous studies have attempted to investigate the most efficient anti-cancer therapy with few side effects and high toxicity on cancer cells to overcome the chemoresistance of cancer cells and the adverse effects of current therapies. In this regard, natural products from edible plants have been assessed as sources of anti-cancer agents. In this article, we review current knowledge from studies that have examined the cytotoxic, anti-tumor and anti-metastatic effects of U. dioica plant on several human cancers. Special attention has been dedicated to the treatment of breast cancer, the most prevalent cancer among women and one of the main causes of death worldwide. The anti-proliferative and apoptotic effects of U. dioica have been demonstrated on different human cancers, investigating the properties of U. dioica at cellular and molecular levels. The potent cytotoxicity and anti-cancer activity of the U. dioica extracts are due to its bioactive natural products content, including polyphenols which reportedly possess anti-oxidant, anti-mutagenic and anti-proliferative properties. The efficacy of this edible plant to prevent or mitigate human cancers has been demonstrated in laboratory conditions as well as in experimental animal models, paving the way to the development of nutraceuticals for new anti-cancer therapies.

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Section: Introductioncontrasting

confidence: 84%

Therapeutic Perspectives of Molecules from Urtica dioica Extracts for Cancer Treatment

et al. 2019

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“…Among the most abundant fatty acids in nettle, palmitic acid and linoleic acid stand out [4,7,9,33,34]. It is a valuable source of vitamins A, B group vitamins, C, D, E, and K, and minerals [7,8,11,[13][14][15][16]31,32,[35][36][37][38], especially P, Ca, Mg, and Fe, the values of which are listed in Table 1 according to various authors. Table 2 lists the content of some SM in stinging nettle identified in various studies.…”

Section: Nutritional Aspects Of Nettlementioning

confidence: 99%

“…All parts of the plant (flowers, stems, leaves and roots) can be used in the food, cosmetic and pharmaceutical industries for their health-promoting properties [8,12,13], as nettle is rich in various biologically active compounds and specialized metabolites (SM) [10]. The phytochemical profile of nettle leaves can be divided into several categories: terpenoids, chlorophylls and carotenoids, fatty acids, polyphenolic acids and compounds, essential amino acids, vitamins, tannins, carbohydrates, sterols, polysaccharides, isolectins and minerals [10,14,15]. According to various studies [1][2][3]16,17], the presence of chemical components in plants is variable, of inconsistent quality and depends on many abiotic, biotic and anthropological factors as well as on the conditions of raw material storage.…”

Section: Introductionmentioning

confidence: 99%

Nettle Cultivation Practices—From Open Field to Modern Hydroponics: A Case Study of Specialized Metabolites

Opačić

Radman

Uher

et al. 2022

Plants

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Conventional agricultural production faces numerous challenges due to the pronounced effects of climate change, particularly global warming, and drought more than ever before in history, with the primary concern being to produce adequate yields and high-quality, nutritious plant material. Likewise, people are increasingly looking for new sources of food and are becoming aware of the importance of a varied diet and its connection to health. In this sense, stinging nettle (Urtica dioica L.) stands out as a valuable species that is neglected as a food source, as it has a significant content of specialized metabolites, and thus has an extremely high potential for use both nutritionally and pharmacologically, but is still traditionally collected from natural habitats, so it can be of questionable quality and undefined chemical composition. Therefore, sustainable agricultural practices are increasingly shifting to modern hydroponic cultivation methods in greenhouses. The advantage lies in the easier management and control of a number of factors during cultivation (air temperature and relative humidity, balanced and rational fertilization, minimization of nitrate uptake, etc.), ensuring better conditions for the growth and development of nettle according to its needs. The aim of this review is to give an overview of the technology of stinging nettle cultivation in the field and to show the possibilities of cultivation with modern hydroponic techniques to obtain a final product of consistent and uniform quality, high content of specialized metabolites and significant nutritional value. Research on this topic is still sparse but will certainly increase in the future. Therefore, this review provides all the necessary data for such future studies.

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“…Fatty acids pro le of SFE extracts was established applying previously described method [11][12][13] using GC-FID (Agilent 7890A) technique. Exact weight of extracts (0,50 g) was directly dissolved in n-hexane and 2M KOH solution in methanol was added (0.60 mL).…”

Section: Determination Of Fatty Acids Pro Lementioning

confidence: 99%

Recovery of biologically active compounds from stinging nettle leaves part I: supercritical fluid extraction

Đurović¹,

Šorgić²,

Popov³

et al. 2021

Preprint

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Stinging nettle (Urtica dioica L.) is annual plant from Urticaceae family growing wild all over the world. Throughout the history, this plant found its place as a both food and medicine. Due to the nonsufficient study, this work aimed to isolate the bioactive compounds from the stinging nettle leaves by supercritical fluid extraction. Extracts were analyzed and assessed for antioxidant and cytotoxic activities. Main fatty acids were α-linolenic, palmitic, and linoleic acids in all six samples. Beside fatty acids, chlorophylls and carotenoids were also found in all samples. Four empirical kinetic equations were effectively utilized for kinetic modeling of supercritical fluid extraction of stinging nettle leaves oil. As per proper statistical features, empirical models show good concurrence with experimental data. The numerical modeling of a process is gainful to foresee the process conduct and furthermore extend the methodology from laboratory to industrial scales. The principal component analysis was used to visualize the fatty acids profile and antioxidant capacity and cytotoxic activity of extract obtained from stinging nettle leaves. It was found that both composition and activity were strongly dependent on the parameters of the extraction process.

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Fatty acid profile of stinging nettle leaves: application of modern analytical procedures for sample preparation and analysis

Abstract: Stinging nettle is a perennial plant with significant biological activity and a long history of application in folk medicine and as food.

Cited by 20 publications

References 19 publications

Therapeutic Perspectives of Molecules from Urtica dioica Extracts for Cancer Treatment

Therapeutic Perspectives of Molecules from Urtica dioica Extracts for Cancer Treatment

Nettle Cultivation Practices—From Open Field to Modern Hydroponics: A Case Study of Specialized Metabolites

Recovery of biologically active compounds from stinging nettle leaves part I: supercritical fluid extraction

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