Fatty acids as suitable biomarkers to assess pesticide impacts in freshwater biological scales – A review

Gonçalves, Ana M.M.; Rocha, Carolina P.; Marques, João Carlos; Gonçalves, Fernando

doi:10.1016/j.ecolind.2020.107299

Cited by 38 publications

(18 citation statements)

References 50 publications

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“…The increase of long-chain fatty acids has been positively correlated with an elevated abundance of Lactobacillus in a rodent model of neonatal maternal separation characterized by accelerated colonic motility and gut dysbiosis, suggesting a relevant role of these molecules on host-microbiota interplay and potentially affecting host metabolism (Zhao et al, 2018). Fatty acid profiles in aquatic ecosystems have been proposed as biomarkers of pesticide exposure (Gonçalves et al, 2021). Short-term exposure to glyphosate or Roundup in the sea cucumber Holothuria forskali perturbed fatty acid composition, including some essential fatty acids (Telahigue et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Alterations in infant gut microbiome composition and metabolism after exposure to glyphosate and Roundup and/or a spore-based formulation using the SHIME technology

et al. 2022

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Despite extensive research into the toxicology of the herbicide glyphosate, there are still major unknowns regarding its effects on the human gut microbiome. We describe the effects of glyphosate and a Roundup glyphosate-based herbicide on infant gut microbiota using SHIME technology. SHIME® microbiota culture was undertaken in the presence of a concentration of 100 mg/L glyphosate and the same glyphosate equivalent concentration of Roundup. Roundup and to a lesser extent glyphosate caused an increase in fermentation activity, resulting in acidification of the microbial environment. This was also reflected by an increase in lactate and acetate production concomitant to a decrease in the levels of propionate, valerate, caproate and butyrate. Ammonium production reflecting proteolytic activities was increased by Roundup exposure. Global metabolomics revealed large scale disturbances, including an increased abundance of long chain polyunsaturated fatty acids. Changes in bacterial composition measured by qPCR and 16S rRNA suggested that lactobacilli had their growth stimulated as a result of microenvironment acidification. Cotreatment with the spore-based probiotic formulation MegaSporeBiotic reverted some of the

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Section: Discussionmentioning

confidence: 99%

Alterations in infant gut microbiome composition and metabolism after exposure to glyphosate and Roundup and/or a spore-based formulation using the SHIME technology

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The increase of long-chain fatty acids has been positively correlated with an elevated abundance of Lactobacillus in a rodent model of neonatal maternal separation characterized by accelerated colonic motility and gut dysbiosis, suggesting a relevant role of these molecules on host-microbiota interplay and potentially affecting host metabolism (Zhao et al 2018). Fatty acid profiles in aquatic ecosystems have been proposed as biomarkers of pesticide exposure (Gonçalves et al 2021). Short-term exposure to glyphosate or Roundup in the sea cucumber Holothuria forskali perturbed fatty acid composition, including some essential fatty acids (Telahigue et al 2021).…”

Section: Discussionmentioning

confidence: 99%

Alterations in human gut microbiome composition and metabolism after exposure to glyphosate and Roundup and/or a spore-based formulation using the SHIME® technology

Mesnage

Calatayud

Duysburgh

et al. 2021

Preprint

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Despite extensive research into the toxicology of the herbicide glyphosate, there are still major unknowns regarding its effects on the human gut microbiome. As a step in addressing this knowledge gap, we describe for the first time the effects of glyphosate and a Roundup glyphosate-based herbicide on infant gut microbiota using SHIME technology, which mimics the entire gastrointestinal tract. SHIME® microbiota culture was undertaken in the presence of a concentration of 100 mg/L (corresponding to a dose of 1.6 mg/kg/day) glyphosate and the same glyphosate equivalent concentration of Roundup, which is in the range of the US chronic reference dose, and subjected to molecular profiling techniques to assess outcomes. Roundup and to a lesser extent glyphosate caused an increase in fermentation activity, resulting in acidification of the microbial environment. This was also reflected by an increase in lactate and acetate production concomitant to a decrease in the levels of propionate, valerate, caproate and butyrate. Ammonium production reflecting proteolytic activities was increased by Roundup exposure. Global metabolomics revealed large scale disturbances in metabolite profiles, including an increased abundance of long chain polyunsaturated fatty acids (n3 and n6). Although changes in bacterial composition measured by qPCR and 16S rRNA sequencing were less clear, our results suggested that lactobacilli had their growth stimulated as a result of microenvironment acidification. Co-treatment with the spore-based probiotic formulation MegaSporeBiotic reverted some of the changes in short-chain fatty acid levels. Altogether, our results suggest that glyphosate can exert effects on human gut microbiota at permitted regulatory levels of exposure, highlighting the need for epidemiological studies aimed at evaluating the effects of glyphosate herbicides on human gut microbiome function.

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“…In addition to these toxicological risks, the use of plant protection products can significantly affect the chemical composition of soybeans [ 12 ]. Recently, it has been shown that fatty acid composition is a candidate indicator to determine the response to pesticides [ 15 ]. Nowadays, the “quick, easy, cheap, effective, rugged, and safe” (QuEChERS) method is an accepted analysis and extraction of pesticides in plant materials [ 16 ], especially in different plant extracts, such as vegetables containing high amounts of oils [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, it has been shown that fatty acid composition is a candidate indicator to determine the response to pesticides [ 15 ]. Nowadays, the “quick, easy, cheap, effective, rugged, and safe” (QuEChERS) method is an accepted analysis and extraction of pesticides in plant materials [ 16 ], especially in different plant extracts, such as vegetables containing high amounts of oils [ 15 ]. In 2022, Tong et al combined the advantages of QuEChERS and gas and liquid chromatography high-resolution mass spectrometry to analyze fatty acid compositions and levels of pesticide residues [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Assessing the Quality of Burkina Faso Soybeans Based on Fatty Acid Composition and Pesticide Residue Contamination

et al. 2022

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Soybean is widely used in the food industry because of its high fatty acid and protein content. However, the increased use of pesticides to control pests during cultivation, in addition to being a public health concern, may influence the nutritional quality of soybeans. This study aimed to assess the nutritional quality of soybeans with respect to fatty acid profile and pesticide residue contamination. The levels of fatty acids and pesticides in soybean varieties G196 and G197 were determined by gas chromatography and by the QuEChERS method, respectively. The results showed a significant variation in the quantitative and qualitative fatty acid composition of the two varieties, with 18.03 g/100 g and 4 fatty acids detected for the G196 variety and 21.35 g/100 g and 7 fatty acids for the G197 variety, respectively. In addition, 12 active pesticide compounds were found, and among them, imazalil, quintozene, cyfluthrin and lindane exceeded their maximum limits. The G197 variety had a better nutritional profile compared to G196. The profile of fatty acids and the content of pesticide residues were used as important determinants for soybean utilization in human nutrition.

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Fatty acids as suitable biomarkers to assess pesticide impacts in freshwater biological scales – A review

Cited by 38 publications

References 50 publications

Alterations in infant gut microbiome composition and metabolism after exposure to glyphosate and Roundup and/or a spore-based formulation using the SHIME technology

Alterations in infant gut microbiome composition and metabolism after exposure to glyphosate and Roundup and/or a spore-based formulation using the SHIME technology

Alterations in human gut microbiome composition and metabolism after exposure to glyphosate and Roundup and/or a spore-based formulation using the SHIME® technology

Assessing the Quality of Burkina Faso Soybeans Based on Fatty Acid Composition and Pesticide Residue Contamination

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