Favorable colorectal cancer mortality-to-incidence ratios in countries with high expenditures on health and development index

Wang, Chi‐Chih; Sung, Wen‐Wei; Yan, Pei-Yi; Ko, Po-Yun; Tsai, Ming‐Chang

doi:10.1097/md.0000000000027414

Cited by 9 publications

(11 citation statements)

References 34 publications

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“…Colorectal cancer (CRC) is the third most frequent cancer in the world and the second leading cause of death related to cancer. The highest rates of morbidity are in Australia and Europe (more than 40/100,000 among men), and the highest mortality rate is in Eastern Europe (more than 20/100,000 among men) [ 3 , 4 ]. It is likely that this situation will intensify in the upcoming decades, particularly in wealthy countries [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Health Behaviors in Quality of Life: A Longitudinal Study of Patients with Colorectal Cancer

Ocalewski

Jankowski

Zegarski

et al. 2023

IJERPH

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Colorectal cancer (CRC) is the third most common malignancy and the second most common cancer-related cause of death worldwide. CRC incidence depends, in part, on the health behaviors that make up an individual’s lifestyle. We aimed to assess the influence of health behaviors and quality of life (QoL) among patients with CRC receiving surgical treatment. In this single-center questionnaire study, 151 patients were surveyed 1 week before and 6 months after colorectal procedures (laparoscopic hemicolectomy, low rectal anterior resection, abdominoperineal resection, and others). This study demonstrated a significant decrease in alcohol consumption and physical activity following the execution of colorectal procedures. No statistically significant changes were observed in smoking or the consumption of healthy food. Global QoL did not change significantly; however, a decrease in physical and role-related functioning was observed. Significant improvements in emotional functioning were also observed. A detailed analysis showed that physical and social functioning were related to smoking, the consumption of healthy food, physical activity, and additional therapies. Emotional functioning was related to smoking, the consumption of healthy food, and complementary treatments. Six months following an operation, it was also dependent on alcohol intake. Physical functioning was the area that decreased the most in the six months after colorectal tumor surgery compared to the period before surgery. Health behaviors such as cessation of smoking, engagement in physical activity, and the consumption of healthy food contributed to a higher quality of life among patients prior to resecting colorectal cancer and six months after the procedure. Patients who received adjuvant/neoadjuvant therapy had a lower quality of life than patients who did not receive this type of therapy. The kind of surgery (laparoscopic hemicolectomy, lower anterior rectum resection, or abdominoperineal rectum resection) was not related to QoL six months after surgery.

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Section: Introductionmentioning

confidence: 99%

The Role of Health Behaviors in Quality of Life: A Longitudinal Study of Patients with Colorectal Cancer

Ocalewski

Jankowski

Zegarski

et al. 2023

IJERPH

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“…This finding is consistent with that of a study on BC epidemiology using MIR proxy from the Global Burden of Disease study data, which found that an inverse correlation was observed between the BC MIR and HDI values, with less developed countries having BC survival statistics ( 17 ). The concept of lower cancer MIR in more developed countries and regions has been examined for several malignancies like colorectal, gastric, prostate, oral cavity, kidney, and liver cancers, all of which indicated the impact of socioeconomic development on improving cancer outcomes from an epidemiological aspect ( 12 , 13 , 16 , 19 , 21 , 24 , 51 ). The findings of this study confirmed most of the studies that used MIR to study cancer care and evaluate healthcare disparities.…”

Section: Discussionmentioning

confidence: 99%

“…One of the well-known and validated proxies of the quality of care, especially for cancer causes, is the mortality-to-incidence ratio (MIR), which has been shown to be a beneficial indicator of global cancer screening and care ( 11 ). To date, MIR has been recruited on various aggregated databases to examine the cancer care status and disparities among different geographic and socioeconomic categories for several cancers, including colorectal ( 11 , 12 ), liver ( 13 ), pancreatic ( 14 ), gastric ( 15 , 16 ), breast ( 17 , 18 ), prostate ( 19 ), and kidney cancers ( 20 , 21 ), and the results have been encouraging.…”

Section: Introductionmentioning

confidence: 99%

“…The human development index (HDI) is one of the most successful measures of socioeconomic development deployed to compare health disparities in recent years ( 22 , 23 ). In addition, countries with high healthcare expenditure and government investments in healthcare have shown favorable cancer outcomes for various malignancies ( 12 , 16 , 20 , 24 ).…”

Section: Introductionmentioning

confidence: 99%

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Patterns of better breast cancer care in countries with higher human development index and healthcare expenditure: Insights from GLOBOCAN 2020

Azadnajafabad

Moghaddam

Mohammadi

et al. 2023

Front. Public Health

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BackgroundThe huge burden of breast cancer (BC) necessitates the profound and accurate knowledge of the most recent cancer epidemiology and quality of care provided. We aimed to evaluate BC epidemiology and quality of care and examine the effects of socioeconomic development and healthcare expenditure on disparities in BC care.MethodsThe results from the GLOBOCAN 2020 study were utilized to extract data on female BC, including incidence and mortality numbers, crude rates, and age-standardized rates [age-standardized incidence rates (ASIRs) and age-standardized mortality rates (ASMRs)]. The mortality-to-incidence ratio (MIR) was calculated for different locations and socioeconomic stratifications to examine disparities in BC care, with higher values reflecting poor quality of care and vice versa. In both descriptive and analytic approaches, the human development index (HDI) and the proportion of current healthcare expenditure (CHE) to gross domestic product (CHE/GDP%) were used to evaluate the values of MIR.ResultsGlobally, 2,261,419 (95% uncertainty interval (UI): 2,244,260–2,278,710) new cases of female BC were diagnosed in 2020, with a crude rate of 58.5/100,000 population, and caused 684,996 (675,493–694,633) deaths, with a crude rate of 17.7. The WHO region with the highest BC ASIR (69.7) was Europe, and the WHO region with the highest ASMR (19.1) was Africa. The very high HDI category had the highest BC ASIR (75.6), and low HDI areas had the highest ASMR (20.1). The overall calculated value of female BC MIR in 2020 was 0.30, with Africa having the highest value (0.48) and the low HDI category (0.53). A strong statistically significant inverse correlation was observed between the MIR and HDI values for countries/territories (Pearson's coefficient = −0.850, p-value < 0.001). A significant moderate inverse correlation was observed between the MIR and CHE/GDP values (Pearson's coefficient = −0.431, p-value < 0.001).ConclusionsThis study highlighted that MIR of BC was higher in less developed areas and less wealthy countries. MIR as an indicator of the quality of care showed that locations with higher healthcare expenditure had better BC care. More focused interventions in developing regions and in those with limited resources are needed to alleviate the burden of BC and resolve disparities in BC care.

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“…Due to the expense of the current screening tests and treatment options, the prognosis of NPCs might be linked to economic status. However, compared with cancers with more established or feasible screening strategies and more therapeutic options, the correlations between MIR and healthcare expenditure on NPC are not as significant as correlations with lung cancer, colorectal cancer, gastric cancer, and lip and oral cancer [ 16 , 17 , 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Mortality-to-Incidence Ratio for Nasopharyngeal Carcinoma Is Associated with Health Expenditure

Chen

et al. 2022

Healthcare

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Geographic and gender-specific disparity can be observed in nasopharyngeal carcinoma (NPC). While screening and more effective therapies, such as induction chemotherapy, could improve survival rates, they are costly. This study aims to explore the correlation between healthcare expenditure and the mortality-to-incidence ratio (MIR) in NPC. Data were obtained from the World Health Organization and the Global Cancer Observatory. The correlation was evaluated by Spearman’s rank correlation coefficient. Most new cases and deaths occur in Asia, and more males are affected than females. Our study shows that countries with higher MIRs have lower levels of health expenditure regardless of the NPC’s gender-specific incidence. Correspondingly, MIRs are all significantly negatively associated with current health expenditure (CHE) per capita and CHE as a percentage of gross domestic product (CHE/GDP) in both genders. CHE per capita and CHE/GDP have a significant impact on NPC outcomes. Moreover, economic status is a potential major factor in MIR differences between countries.

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Favorable colorectal cancer mortality-to-incidence ratios in countries with high expenditures on health and development index

Cited by 9 publications

References 34 publications

The Role of Health Behaviors in Quality of Life: A Longitudinal Study of Patients with Colorectal Cancer

The Role of Health Behaviors in Quality of Life: A Longitudinal Study of Patients with Colorectal Cancer

Patterns of better breast cancer care in countries with higher human development index and healthcare expenditure: Insights from GLOBOCAN 2020

Mortality-to-Incidence Ratio for Nasopharyngeal Carcinoma Is Associated with Health Expenditure

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