Favouring a Dignified End to Human Life: Common Cause v. Union of India

Abstract

An improved synthesis of the title compound, C12HI0-N20, via the reaction of 6-(4-methylphenyl)-4-methylthio-2-oxo-2H-pyran-3-carbonitrile and hydroxylamine hydrochloride in pyridine is reported. The isoxazole ring is planar and is inclined at an angle of 34.2 (1) ° with respect to the aromatic ring. All bond lengths and angles are unexceptional. CommentIsoxazoles are known to possess a range of biological activities, a particularly important example being antispasmodic activity (Naruto et al., 1982, 1983). In this context, an interesting reaction has recently been reported (Ram, Hussaini, Singh & Shoeb, 1993) in which three different compounds [(II)-(IV)] having an isoxazole moiety are obtained in one stepby the treatment of 6-(4-methylphenyl)-4-methylthio-Acta Crystallographica Section C