Fc RIIa polymorphism: a susceptibility factor for immune complex-mediated lupus nephritis in Brazilian patients

Bazilio, Ana Paula; Viana, Vilma Santos Trindade; Toledo, Rui; Woronik, Viktoria; Bonfá, Eloísa; Monteiro, Renato C.

doi:10.1093/ndt/gfh121

Cited by 26 publications

(21 citation statements)

References 20 publications

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“…Genotyping for FcγRIIa H131R polymorphism (rs1801274) was performed as described by Bazilio and others. 31 In brief, a nested polymerase chain reaction (PCR) approach was used using two sets of primers, the outer primer pair and inner primer pair. The outer primer set consisted of forward primer P63-F (5′-CAAGCCTCTGGTCAAGGTC-3′) and reverse primer P63-R (5′-CAATGACCACAGCCACAATC-3′), which amplified a 1-kb segment of FcγRIIa gene that contained exon 4 and a portion of exon 5, with intronic sequence in between.…”

Section: Methodsmentioning

confidence: 99%

Association of FcγRIIa Polymorphism with Clinical Outcome of Dengue Infection: First Insight from Pakistan

Mohsin

Mahmood

Amar

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. Dengue illness has been a major health concern in Pakistan during the last decade. Dengue infection can result in a spectrum of clinically distinct outcomes, ranging from asymptomatic infection to potentially life-threatening forms of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). A single-nucleotide polymorphism in FcγRIIa (rs1801274) results in altered affinity of the receptor for different subclasses of immunoglobulin G, and is a key player in determining the susceptibility to or protection from severe clinical infection of dengue. In this study, we analyzed the allelic and genotypic distribution of rs1801274 in subjects of Pakistani origin with subclinical dengue infection (n = 40), dengue fever (DF) (n = 40), and DHF/DSS (n = 30). We found that HH homozygotes and heterozygotes were significantly more likely to develop clinical dengue (odds ratio [OR] = 3.21, 95% confidence interval [CI] = 1.29-7.97, P = 0.009), either DF (OR = 2.82, 95% CI = 1.00-7.97, P = 0.045) or DHF/DSS (OR = 3.90, 95% CI = 1.13-13.07, P = 0.024) than the asymptomatic dengue infection. Results of allelic distribution comparisons and logistic regression analysis also supported the same relationship. The results suggest complex nature of interacting factors in determining the course for severe dengue illness.

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Section: Methodsmentioning

confidence: 99%

Association of FcγRIIa Polymorphism with Clinical Outcome of Dengue Infection: First Insight from Pakistan

Mohsin

Mahmood

Amar

et al. 2015

The American Society of Tropical Medicine and Hygiene

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“…To determine the polymorphism associated to FcγRIIa, the protocol by Bazilio and others 16 was used. The polymerase chain reaction (PCR) was carried out to amplify the genetic region of interest using oligonucleotide primers previously published.…”

Section: Samplesmentioning

confidence: 99%

“…The polymerase chain reaction (PCR) was carried out to amplify the genetic region of interest using oligonucleotide primers previously published. 16 Specifically, a 1-kb portion of the FcγRIIa gene, containing exon 4 and part of exon 5 separated by an intron, was amplified by PCR using sense primer P63 (5'-CAAGCCTCTGGTCAAGGTC) and antisense primer FcγRII-30 (5¢-CAATGACCACAGCCACAA TC). Nested PCR was performed using the specific sense primers 494A and 494G (5¢-ATTCTCCC[A/G]TTTGGATC), respectively and P52 as an antisense primer (5¢-GAAGA GCTGCCCATGCTG).…”

Section: Samplesmentioning

confidence: 99%

Asymptomatic Dengue Infection in a Cuban Population Confirms the Protective Role of the RR Variant of the FcγRIIa Polymorphism

Garcı́a¹,

Sierra²,

Pérez³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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Abstract. The role of human Fcγ receptors (FcγR) has been recognized considerably over the last years. These receptors vary in their affinity for IgG subclasses and the intracellular signals elicited by them. Allelic variants of FcγR genes may influence the biological phagocyte activity, accounting for an inherited pre-disposition to disease. The specific FcγRIIa (CD32) contains a polymorphic variant (H/R131) that has been associated to a reduced risk for developing dengue hemorrhagic fever (DHF). Here, we investigated the role of this polymorphism in a very well-characterized group of Cuban individuals with antecedents of DHF, dengue fever (DF), or subclinical dengue infection. The HH131 genotype was significantly associated with dengue disease, either DF (* P = 0.016; odds ratio = 4.425; 95% confidence interval = 1.10-20.52) or DHF ( P = 0.00018; odds ratio = 10.56; 95% confidence interval = 2.33-54.64) with respect to the subclinical infection.

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“…In the majority of studies, however, the low-affinity alleles have been identified as risk factors for the development or severity of autoimmune disease. Several studies have found an association of the low-affinity FcγRIIIA 158F and the FcγRIIA 131R alleles with the incidence and severity of lupus nephritis and arthritis [71,[125][126][127][128][129][130][131][132][133][134][135][136][137]. In addition, the low-affinity allele of human FcγRIIIB (FcγRIIIB-NA2) has been associated with SLE [71,138,139].…”

Section: The Activating Fcrs In the Efferent Responsementioning

confidence: 99%

“…For example, studies in African-American, Brazilian, German, and Thai populations have found significant associations between the FcγRIIA 131R allele and SLE disease susceptibility or severity of nephritis [71,126,128,129,131,133,136,137,144]. Moreover, several studies in Caucasian, Dutch, and Korean populations have found associations between the FcγRIIIA 158F allele and disease susceptibility and severity [127,130,134,145].…”

Section: The Activating Fcrs In the Efferent Responsementioning

confidence: 99%

Activating and inhibitory FcγRs in autoimmune disorders

Nimmerjahn

2006

Springer Semin Immun

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Autoimmune disorders are characterized by the destruction of self-tissues by the immune system. Multiple checkpoints are in place to prevent autoreactivity under normal circumstances. Coexpression of activating and inhibitory Fc receptors (FcR) represents such a checkpoint by establishing a threshold for immune cell activation. In many human autoimmune diseases, however, balanced FcR expression is disturbed. Analysis of murine model systems provides strong evidence that aberrant FcR expression can result in uncontrolled immune responses and the initiation of autoimmune disease. This review will summarize this data and explain how this information might be used to better understand human autoimmune diseases and to develop novel therapeutic strategies.

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Fc RIIa polymorphism: a susceptibility factor for immune complex-mediated lupus nephritis in Brazilian patients

Abstract: The skewed distribution of Fc gamma RIIa genotypes with the predominance of homozygous R/R131 genotype observed in lupus nephritis emphasizes its importance as a heritable risk factor for IC-mediated renal injury in Brazilian lupus patients.

Cited by 26 publications

References 20 publications

Association of FcγRIIa Polymorphism with Clinical Outcome of Dengue Infection: First Insight from Pakistan

Association of FcγRIIa Polymorphism with Clinical Outcome of Dengue Infection: First Insight from Pakistan

Asymptomatic Dengue Infection in a Cuban Population Confirms the Protective Role of the RR Variant of the FcγRIIa Polymorphism

Activating and inhibitory FcγRs in autoimmune disorders

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