FDG-PET SUV can distinguish between spinal sarcoidosis and myelopathy with canal stenosis

“…There are several case reports and research studies of spinal cord sarcoidosis on MR imaging; however, most of these articles have been reported in Western countries. There have been only a few research reports describing the initial MR findings in Japanese patients with spinal cord sarcoidosis (7)(8)(9). Therefore, further exploration and accumulation of cases of spinal cord sarcoidosis is necessary due to the rarity of this condition.…”

Section: Introductionmentioning

confidence: 99%

Spinal Magnetic Resonance Imaging Manifestations at Neurological Onset in Japanese Patients with Spinal Cord Sarcoidosis

2013

View full text Add to dashboard Cite

Objective We retrospectively investigated spinal magnetic resonance imaging (MRI) manifestations at neurological onset in Japanese patients with spinal cord sarcoidosis. Methods Between July 2000 and April 2012, we reviewed our database and recruited patients with spinal cord sarcoidosis. On spinal MRI performed at neurological onset, the following items were evaluated: the vertebral-segment distribution and length of intramedullay T2-elongated lesions, abnormal enhancement patterns and distributions and the concomitant presence of spondylosis and associated extraspinal lesions. If available, brain MRI scans were concomitantly assessed. Results Nine patients were enrolled (four men and five women; median, 49 years). Reflecting Japanese epidemiological backgrounds, a predilection for occurrence was observed in young men and middle-aged women. Intramedullary T2-elongated lesions were present in eight patients, peaking at the C5 level, with a mean length of 3.7±2.6 vertebral segments. Spondylosis coexisted in the middle-aged patients. Abnormal intramedullary enhancement with concomitantly involved the nerve roots was observed in six patients, comprised of two types reflecting the disease progression: linear-and/or nodular enhancement along the surface of the spinal cord and intramedullary enhancement consisting of patchy, broad-based enhancement adjacent to the cord surface. Five patients had associated extraspinal lesions, including lymphadenopathy in four patients and brain involvement in four patients. Conclusion Spinal cord sarcoidosis exhibits a predilection for young men and middle-aged women among Japanese individuals and is characterized by intramedullary T2-elongated lesions spreading more than three vertebral segments peaking at the C5 level, two types of abnormal intramedullary enhancement reflecting disease progression, frequent nerve root involvement and lymphadenopathy.

show abstract

“…Therapy such as radiation therapy, chemotherapy, or surgery might affect FDG uptake in the spinal cord 8-12. Also, many diseases, including spinal metastasis,13,14 spinal sarcoidosis,15,16 and myelopathy,17-19 can increase FDG uptake in the spinal cord. In addition, knowledge about possible variations of FDG uptake in the spinal cord of a normal population is fundamental for monitoring the spinal cord in various clinical settings.…”

Section: Introductionmentioning

confidence: 99%

Changes in¹⁸F-Fluorodeoxyglucose Uptake in the Spinal Cord in a Healthy Population on Serial Positron Emission Tomography/Computed Tomography

et al. 2013

View full text Add to dashboard Cite

We aimed to determine the changes in 18F-fluorodeoxyglucose (FDG) uptake in the spinal cord on two serial positron emission tomography/computed tomography (PET/CT) scans in a healthy population. We retrospectively enrolled healthy people who underwent PET/CT twice for cancer screening. We excluded those who had degenerative vertebral disease, neurologic disease, or a history of a vertebral operation. The standardized uptake value (SUVmax) of the spinal cord of each mid-vertebral body was obtained by drawing a region of interest on an axial image of PET/CT. For analysis, the cord-to-background ratio (CTB) was used (CTB=SUVmax of each level/SUVmax of L5 level). Differences in pattern, sex, age, and intervals of the two serial PET/CT scans were analyzed. A total of 60 PET/CT images of 30 people were analyzed. The mean interval between the two PET/CT imaging studies was 2.80±0.94 years. On the follow-up PET/CT, significant change was shown only at the level of the C6 and T10 vertebrae (p<0.005). Mean CTB showed a decreasing pattern from cervical to lumbar vertebrae. There were two peaks at the lower cervical level (C4-6) and at the lower thoracic level (T12). Neither sex nor age significantly affected CTB. The FDG uptake of the spinal cord changed significantly on follow-up PET/CT only at the level of the C6 and T10 vertebrae. This finding is valuable as a baseline reference in the follow-up of metabolic changes in the spinal cord.

show abstract

FDG-PET SUV can distinguish between spinal sarcoidosis and myelopathy with canal stenosis

Abstract: 242 wordsText: 1047 words Running head:Standard uptake value in the spinal cord sarcoidosis Key words:FDG-PET, standard uptake value, spinal cord sarcoidosis, myelopathy, canal stenosis

Cited by 26 publications

References 8 publications

Clinical features of spinal cord sarcoidosis: analysis of 17 neurosarcoidosis patients

Clinical features of spinal cord sarcoidosis: analysis of 17 neurosarcoidosis patients

Spinal Magnetic Resonance Imaging Manifestations at Neurological Onset in Japanese Patients with Spinal Cord Sarcoidosis

Changes in¹⁸F-Fluorodeoxyglucose Uptake in the Spinal Cord in a Healthy Population on Serial Positron Emission Tomography/Computed Tomography

Contact Info

Product

Resources

About

FDG-PET SUV can distinguish between spinal sarcoidosis and myelopathy with canal stenosis

Abstract: 242 wordsText: 1047 words Running head:Standard uptake value in the spinal cord sarcoidosis Key words:FDG-PET, standard uptake value, spinal cord sarcoidosis, myelopathy, canal stenosis

Cited by 26 publications

References 8 publications

Clinical features of spinal cord sarcoidosis: analysis of 17 neurosarcoidosis patients

Clinical features of spinal cord sarcoidosis: analysis of 17 neurosarcoidosis patients

Spinal Magnetic Resonance Imaging Manifestations at Neurological Onset in Japanese Patients with Spinal Cord Sarcoidosis

Changes in18F-Fluorodeoxyglucose Uptake in the Spinal Cord in a Healthy Population on Serial Positron Emission Tomography/Computed Tomography

Contact Info

Product

Resources

About

Changes in¹⁸F-Fluorodeoxyglucose Uptake in the Spinal Cord in a Healthy Population on Serial Positron Emission Tomography/Computed Tomography