FDG Uptake in Gestational Sac

Alibazoglu, Haluk; Kim, R.; Ali, Arafat; Green, A.; Monica, G.

doi:10.1097/00003072-199708000-00011

Cited by 8 publications

(24 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Five pregnant patients referred to our PET center for oncologic 18 F-FDG PET scans were included in this retrospective study. All 5 patients had a biopsy-proven diagnosis of cancer, and all, except for 1, had established pregnancy at the time of 18 F-FDG PET.…”

Section: Methodsmentioning

confidence: 99%

“…Not only has the use rate of imaging in the general patient population grown dramatically over the past few decades, but radiologic imaging in pregnant patients has also increased (6). 18 F-FDG PET and PET/CT have now become the standard of care for evaluation and workup of many neoplasms, including most of the malignancies that can occur in pregnant patients. However, most of the literature addressing the safety of imaging during pregnancy omits PET and PET/CT modalities because of the lack of data regarding the safety and radiation exposure risks to the fetus (7,8).…”

mentioning

confidence: 99%

“…Lack of accurate, scientific data about the risks and benefits of 18 F-FDG PET in diseased pregnant patients combined with medical liability concerns may result in a conservative and potentially inappropriate choice to withhold necessary medical imaging in such situations. The purpose of this article is to document our successful experiences with 18 F-FDG PET in pregnant patients and to attempt to assess the fetal radiation exposure resulting from 18 F-FDG PET procedures.…”

mentioning

confidence: 99%

See 2 more Smart Citations

¹⁸F-FDG PET in Pregnancy and Fetal Radiation Dose Estimates

et al. 2011

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

¹⁸F-FDG PET in Pregnancy and Fetal Radiation Dose Estimates

et al. 2011

View full text Add to dashboard Cite

“…As a consequence, an ever-increasing number of pregnant women are injected with radiopharmaceuticals (2). Fetal radiation exposure may be accidental if the pregnancy is unknown at the time of the PET scan (3)(4)(5)(6) or may be the consequence of a diagnostic workup for cancer in the mother (7)(8)(9). In both cases, knowing the fetal absorbed dose is important for correctly assessing the risk to the fetus and for putting this risk in perspective against the clinical benefit for the mother.…”

mentioning

confidence: 99%

Fetal Radiation Dose from ¹⁸F-FDG in Pregnant Patients Imaged with PET, PET/CT, and PET/MR

2015

View full text Add to dashboard Cite

The fetal radiation dose from 18 F-FDG was estimated in a series of pregnant women who underwent a PET scan during a clinical workup for malignancies. Methods: Six pregnant patients were injected with 18 F-FDG (activity range, 296-385 MBq). Three patients were scanned during the first trimester (1 with PET and 2 with PET/CT), 2 were scanned during the second trimester (with PET/MR imaging), and 1 was scanned during the third trimester (with PET). The time-integrated activity coefficients were derived from the fetal radioactivity concentrations measured on the images for all but 1 patient (in early pregnancy [5 wk]), in whom the activity in the uterus was used as a proxy. The coefficients of the mother's organs were derived from standard values (from the International Commission on Radiological Protection). Results: Fetal doses ranged from 6.29E-03 to 2.46E-02 mGy/MBq. An earlier bladder voiding reduced these doses by 25%-45%. The 2 patients who underwent PET/MR imaging-in whom fetal contours could be accurately delineated-displayed the lowest fetal absorbed dose, likely because of more accurate region drawing, with the inclusion of areas of both low and high fetal uptake. Moreover, PET/MR imaging did not necessitate additional radiation for attenuation correction. The placenta, delineated on a PET/MR imaging scan, concentrated 0.27% of the injected activity. Conclusion: Fetal radiation doses are higher in early pregnancy than in late pregnancy, and there can be considerable intersubject variability. However, the total absorbed dose is always well below the threshold for noncancer health effects throughout pregnancy. PET/MR imaging is the optimal PET procedure for imaging pregnant women because it is not associated with radiation for attenuation correction and allows more accurate dosimetric calculations.

show abstract

“…Several million 18 F-FDG PET examinations are performed yearly worldwide. Reports of 18 F-FDG PET examinations accidentally performed during pregnancy are exceedingly rare (3). Estimates of the dose received by the embryo or fetus are thus essentially theoretic.…”

mentioning

confidence: 99%

Estimation of the β+ Dose to the Embryo Resulting from ¹⁸F-FDG Administration During Early Pregnancy: FIGURE 1.

Zanotti‐Fregonara¹,

Champion²,

Trébossen³

et al. 2008

J Nucl Med

View full text Add to dashboard Cite

Although 18 F-FDG examinations are widely used, data are lacking on the dose to human embryo tissues in cases of exposure in early pregnancy. Although the photon component can easily be estimated from available data on the pharmacokinetics of 18 F-FDG in female organs and from phantom measurements (considering the uterus as the target organ), the intensity of embryo tissue uptake, which is essential for deriving the b1 dose, is not known. We report the case of a patient who underwent 18 F-FDG PET/CT for tumor surveillance and who was later found to have been pregnant at the time of the examination (embryo age, 8 wk). Methods: The patient received 320 MBq of 18 F-FDG. Imaging started with an unenhanced CT scan 1 h after the injection, followed by PET acquisition. PET images were used to compute the total number of b1 emissions in embryo tissues per unit of injected activity, from standardized uptake value (SUV) measurements corrected for partial-volume effects. A Monte Carlo track structure code was then used to derive the b1 self-dose and the b1 cross-dose from amniotic fluid. The photon and CT doses were added to obtain the final dose received by the embryo. Results: The mean SUV in embryo tissues was 2.7, after correction for the partial-volume effect. The mean corrected SUV of amniotic fluid was 1.1. Monte Carlo simulation showed that the b1 dose to the embryo (self-dose plus crossdose from amniotic fluid) was 1.8E22 mGy per MBq of injected 18 F-FDG. Based on MIRD data for the photon dose to the uterus, the estimated photon dose to the embryo was 1.5E22 mGy/ MBq. Thus, the specific 18 F-FDG dose to the embryo was 3.3E22 mGy/MBq (10.6 mGy in this patient). The CT scan added a further 8.3 mGy. Conclusion: The dose to the embryo is 3.3E22 mGy/MBq of 18 F-FDG. The b1 dose contributes 55% of the total dose. This value is higher than previous estimates in late nonhuman-primate pregnancies.

show abstract

FDG Uptake in Gestational Sac

Cited by 8 publications

References 0 publications

¹⁸F-FDG PET in Pregnancy and Fetal Radiation Dose Estimates

¹⁸F-FDG PET in Pregnancy and Fetal Radiation Dose Estimates

Fetal Radiation Dose from ¹⁸F-FDG in Pregnant Patients Imaged with PET, PET/CT, and PET/MR

Estimation of the β+ Dose to the Embryo Resulting from ¹⁸F-FDG Administration During Early Pregnancy: FIGURE 1.

Contact Info

Product

Resources

About

FDG Uptake in Gestational Sac

Cited by 8 publications

References 0 publications

18F-FDG PET in Pregnancy and Fetal Radiation Dose Estimates

18F-FDG PET in Pregnancy and Fetal Radiation Dose Estimates

Fetal Radiation Dose from 18F-FDG in Pregnant Patients Imaged with PET, PET/CT, and PET/MR

Estimation of the β+ Dose to the Embryo Resulting from 18F-FDG Administration During Early Pregnancy: FIGURE 1.

Contact Info

Product

Resources

About

¹⁸F-FDG PET in Pregnancy and Fetal Radiation Dose Estimates

¹⁸F-FDG PET in Pregnancy and Fetal Radiation Dose Estimates

Fetal Radiation Dose from ¹⁸F-FDG in Pregnant Patients Imaged with PET, PET/CT, and PET/MR

Estimation of the β+ Dose to the Embryo Resulting from ¹⁸F-FDG Administration During Early Pregnancy: FIGURE 1.