Fe in biosynthesis, translocation, and signal transduction of NO: toward bioinorganic engineering of dinitrosyl iron complexes into NO-delivery scaffolds for tissue engineering

Hsiao, Hui‐Yi; Chung, Chieh-Wei; Santos, J. H. M.; Villaflores, Oliver B.; Lu, Tsai‐Te

doi:10.1039/c9dt00777f

Cited by 61 publications

(59 citation statements)

References 270 publications

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“…As the richest transition metal ion in humans, iron can cause a decrease in vasodilation by inhibiting the biosynthesis, transportation, transformation, and signal transduction of NO (76,77). Low ferritin and vitamin D levels have been found in adolescents with POTS (78).…”

Section: Iron Insufficiencymentioning

confidence: 99%

Postural Tachycardia Syndrome in Children and Adolescents: Pathophysiology and Clinical Management

Chen

Jin

et al. 2020

Front. Pediatr.

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Postural tachycardia syndrome (POTS), characterized by chronic (≥6 months) orthostatic intolerance symptoms with a sustained and excessive heart rate increase while standing without postural hypotension, is common in children and adolescents. Despite the unclear pathogenesis of POTS, the present opinion is that POTS is a heterogeneous and multifactorial disorder that includes altered central blood volume, abnormal autonomic reflexes, "hyperadrenergic" status, damaged skeletal muscle pump activity, abnormal local vascular tension and vasoactive factor release, mast cell activation, iron insufficiency, and autoimmune dysfunction. A number of pediatric POTS patients are affected by more than one of these pathophysiological mechanisms. Therefore, individualized treatment strategies are initiated in the management of POTS, including basal non-pharmacological approaches (e.g., health education, the avoidance of triggers, exercise, or supplementation with water and salt) and special pharmacological therapies (e.g., oral rehydration salts, midodrine hydrochloride, and metoprolol). As such, the recent progress in the pathogenesis, management strategies, and therapeutic response predictors of pediatric POTS are reviewed here.

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Section: Iron Insufficiencymentioning

confidence: 99%

Postural Tachycardia Syndrome in Children and Adolescents: Pathophysiology and Clinical Management

Chen

Jin

et al. 2020

Front. Pediatr.

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“…In addition to LiCl, several studies have suggested the neuroprotective properties of nitric oxide (NO) (21,22). To explore the protective functions of NO in the Drosophila model, a novel NO releasing compound, dinitrosyl iron complex [(NO)2Fe(µ-SCH2CH2OH)2Fe(NO)2] (DNIC-1), was supplemented in the food (23)(24)(25)(26). As shown in Fig.…”

Section: A Novel and Steady No-releasing Dinitrosyl Iron Complex (Dnimentioning

confidence: 99%

“…In that case, learning how these long-lived flies perform in the VBFD assay will allow us to substantiate and characterize the functional inter-connections between the peripheral tissue/organ and the central nervous system, such as the gut-brain communications (10,37,38). The design of DNIC-1 [(NO)2Fe(µ-SCH2CH2OH)Fe(NO)2], a novel NO-delivery reagent used in this study, is based on a natural motif, dinitrosyl iron unit [Fe(NO)2] for the delivery and storage of NO (23)(24)(25)(26). In comparison to the burst release of NO by the FDA-approved organic nitrates and wellstudied NONOates, DNIC-1 displays a steady kinetics for O2-triggered release of NO (half-life = 27.4 hrs at pH7.4, 22-25℃), providing a more stable source of ectopic NO under physiological conditions.…”

Section: Neural Circuits That Govern the Efficacy Of Vbfdmentioning

confidence: 99%

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Assessing the Cognitive Status of Drosophila by the Value-Based Feeding Decision

Kao

Chang

et al. 2020

Preprint

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Decision making is considered an important aspect of cognitive function. Impaired decision making is a consequence of cognitive decline caused by various physiological conditions, such as aging and neurodegenerative diseases. Here we exploited the value-based feeding decision (VBFD) assay, which is a simple sensory-motor task, to determine the cognitive status of Drosophila. Our results indicated the deterioration of VBFD is notably correlated with aging and neurodegenerative disorders. Restriction of the mushroom body (MB) neuronal activity partly blunted the proper VBFD. Furthermore, using the Drosophila polyQ disease model, we demonstrated the impaired VBFD is ameliorated by the dinitrosyl iron complex (DNIC-1), a novel and steady nitric oxide (NO)-releasing compound. Therefore we propose that the VBFD assay provides a robust assessment of Drosophila cognition and can be used to characterize additional neuroprotective interventions.

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“…DNICs chemistry is very important in the field of biology, as well as bioinorganic chemistry. In addition, some NO bound structures have also been reported in nitric oxide reductase [14][15][16].…”

Section: Introductionmentioning

confidence: 98%

Structures and Properties of Dinitrosyl Iron and Cobalt Complexes Ligated by Bis(3,5-diisopropyl-1-pyrazolyl)methane

2019

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Two dinitrosyl iron and cobalt complexes [Fe(NO)2(L1”)](BF4) and [Co(NO)2(L1”)](BF4) are synthesized and characterized, supported by a less hindered bidentate nitrogen ligand bis(3,5-diisopropyl-1-pyrazolyl)methane (denoted as L1”), are surprisingly stable under argon atmosphere. X-ray structural analysis shows a distorted tetrahedral geometry. Spectroscopic and structural parameters of the dinitrosyl iron and cobalt complexes are consistent with the previous reported {Fe(NO)2}9 and {Co(NO)2}10. Two N–O and M–N(O) stretching frequencies and their magnetic properties are also consistent with the above electronic structural assignments. We explored the dioxygen reactivities of the obtained dinitrosyl complexes. Moreover, the related [FeCl2(L1”)], [Co(NO3)2(L1”)], and [Co(NO2)2(L1”)] complexes are also characterized in detail.

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Fe in biosynthesis, translocation, and signal transduction of NO: toward bioinorganic engineering of dinitrosyl iron complexes into NO-delivery scaffolds for tissue engineering

Abstract: The ubiquitous physiology of nitric oxide enables the bioinorganic engineering of [Fe(NO)2]-containing and NO-delivery scaffolds for tissue engineering.

Cited by 61 publications

References 270 publications

Postural Tachycardia Syndrome in Children and Adolescents: Pathophysiology and Clinical Management

Postural Tachycardia Syndrome in Children and Adolescents: Pathophysiology and Clinical Management

Assessing the Cognitive Status of Drosophila by the Value-Based Feeding Decision

Structures and Properties of Dinitrosyl Iron and Cobalt Complexes Ligated by Bis(3,5-diisopropyl-1-pyrazolyl)methane

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