Fe3O4 Nanoparticles for Complex Targeted Delivery and Boron Neutron Capture Therapy

Dukenbayev, Kanat; Korolkov, Ilya V.; Тишкевич, Д.И.; Kozlovskiy, Artem L.; Труханов, С. В.; Gorin, Yevgeniy G.; Shumskaya, Elena; Kaniukov, Egor; Винник, Д.А.; Zdorovets, Maxim V.; Анисович, М. В.; Труханов, А.В.; Tosi, Daniele; Molardi, Carlo

doi:10.3390/nano9040494

Cited by 147 publications

(51 citation statements)

References 80 publications

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“…Materials in nanoform are very important at the moment, because they can have electronic properties that are more attractive than their bulk counterparts. Lately, many works have been devoted to obtaining and studying the properties of ferrites in nanoform [10][11][12][13][14]. In addition, magnetic materials are also of interest in nanoscale magnetic phase separation.…”

Section: Introductionmentioning

confidence: 99%

Peculiarities of the Crystal Structure Evolution of BiFeO3–BaTiO3 Ceramics across Structural Phase Transitions

et al. 2020

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Evolution of the crystal structure of ceramics BiFeO3–BaTiO3 across the morphotropic phase boundary was analyzed using the results of macroscopic measuring techniques such as X-ray diffraction, differential scanning calorimetry, and differential thermal analysis, as well as the data obtained by local scale methods of scanning probe microscopy. The obtained results allowed to specify the concentration and temperature regions of the single phase and phase coexistent regions as well as to clarify a modification of the structural parameters across the rhombohedral–cubic phase boundary. The structural data show unexpected strengthening of structural distortion specific for the rhombohedral phase, which occurs upon dopant concentration and temperature-driven phase transitions to the cubic phase. The obtained results point to the non-monotonous character of the phase evolution, which is specific for metastable phases. The compounds with metastable structural state are characterized by enhanced sensitivity to external stimuli, which significantly expands the perspectives of their particular use.

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Section: Introductionmentioning

confidence: 99%

Peculiarities of the Crystal Structure Evolution of BiFeO3–BaTiO3 Ceramics across Structural Phase Transitions

et al. 2020

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“…Nonetheless, the principal focus is on enhancing the dielectric and magnetic properties. Within the recent past, however, the developments of the three-phase dielectric, dielectric and magnetic polymer polymers offer further choices on the design and expansion of the material application, like those utilized within the sensors and inductor capacitors [33][34][35][36][37][38].The weather-shed of out of doors insulators and cable terminators is typically employed by polymeric insulation materials like epoxy and polyethene. Additionally, to their other uses in modern technology, epoxy resins are commonly used as suitable matrices, as they supply flexibility, low shrinking, additives, high dielectric properties, and excellent adhesion.…”

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confidence: 99%

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confidence: 99%

Investigation of AC-Measurements of Epoxy/Ferrite Composites

et al. 2020

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A pure ferrite and epoxy samples as well as the epoxy/ferrite composites with different 20 wt.%, 30 wt.%, 40 wt.%, and 50 wt.% weight ferrite contents have been prepared by the chemical co-precipitation method. AC-conductivity and dielectric properties such as the dielectric constant and dielectric loss of the prepared samples have been studied. The obtained results showed that the samples had a semiconductor behavior. The dielectric constant of the composites has been calculated theoretically using several models. For the composite sample that contains 20 wt.% of ferrites, these models give satisfactory compliance, while for the composite samples with a higher percentage of nanofillers, more than 30 wt.% theoretical results do not coincide with experimental data. The investigated polymer has very low conductivity, so this type of polymer can be useful for high-frequency applications, which can reduce the losses caused by eddy current. Thus, the prepared samples are promising materials for practical use as elements of microwave devices.Nanomaterials 2020, 10, 492 2 of 16 Nanotechnology can be an excellent tool in the study, preparation, research, and use of new perspective materials, as well as in solving the problem of particles sizes in the range of 1-100 nm, where unusual phenomena allow new applications [2][3][4]. Tiny nanoparticles with diameters of some nanometers usually look like molecules. Therefore, the atomic and electronic structures of such small nanoparticles possess different features, certainly not the same as those of the bulk materials. The size-dependent abilities of nanoparticles include electronic, magnetic, optical, and chemical substance characteristics. Nanoparticles can be crystalline or amorphous [5].Nanosized ferrites could be prepared by many methods, including mechanized milling, ultrasonic cavitation method, radio rate of recurrence plasma, hydrothermal technique, reverse micelle method, sol-gel technique, citrate precursor, and co-precipitation technique [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. It is advisable to possess a synthesis method that allows for governor on the nanoparticle dimension and produces nanoparticles having a significant size distribution [2]. The chemical substance co-precipitation method is the most excellent ideal for the formation of nanoparticles due to its ease and much-improved handle over the crystallite dimension and other qualities of the components [22]. Also, lately, magnetic composites comprising magnetic materials alongside polymers comprise a new era of multifunctional components that mix the properties from the constituents; these components are known as magneto-polymeric components [23].The characteristics of ferrites are highly susceptible to methodical handling, sintering conditions, and impurity. Nickel-zinc ferrite is one of the first widely used ferrite produced for an open range of applications that recognizes to high saturation magnetization, high resistance, high Curie temperature, high chemical stability, low coerciv...

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“…E: carboranyl nucleosides [42]. F: boron-containing nanoparticles [44] compounds indicated above, third-generation agents including one or more polyhedral anions of borane or carboranes have been investigated [30]. The stable boron delivery agents with low and high molecular weight connected with a tumor-targeting component or moiety via a hydrolytically stable linkage (boron carriers) belong to this group of compounds ( Figure 2).…”

Section: Third-generation Boron Compoundsmentioning

confidence: 99%

“…The stable boron delivery agents with low and high molecular weight connected with a tumor-targeting component or moiety via a hydrolytically stable linkage (boron carriers) belong to this group of compounds ( Figure 2). In particular, these thirdgeneration boron compounds include boronated DNA intercalators [30], boronated amino acids [31], boronated lipopeptides [32], boronated peptides [33], boronated folate receptor [34], boronated epidermal growth factor (EGF) or epidermal growth factor receptor (EGFR) monoclonal antibodies (MAbs) [35], boron-containing immunoliposomes [36] and liposomes [37,38], BSH-loaded polymeric micelles [39], transferrin-polyethylene glycol liposomes [40], maleimide-functionalized closo-dodecaborate albumin conjugates [41], carboranyl nucleosides [42], boronated porphyrins [43], boron-containing nanoparticles [44] coupled with cationic microbubble-assisted focused ultrasound (MB+FUS) treatment [45], pentanuclear porphyrazine complexes [46], boronated cyclic peptides [47], and boron nitride nanotubes [48].…”

Section: Third-generation Boron Compoundsmentioning

confidence: 99%

Boron neutron capture therapy: Current status and future perspectives

Дымова

Taskaev

Richter

et al. 2020

Cancer Communications

188

173

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The development of new accelerators has given a new impetus to the development of new drugs and treatment technologies using boron neutron capture therapy (BNCT). We analyzed the current status and future directions of BNCT for cancer treatment, as well as the main issues related to its introduction. This review highlights the principles of BNCT and the key milestones in its development: new boron delivery drugs and different types of charged particle accelerators are described; several important aspects of BNCT implementation are discussed. BCNT could be used alone or in combination with chemotherapy and radiotherapy, and it is evaluated in light of the outlined issues. For the speedy implementation of BCNT in medical practice, it is necessary to develop more selective boron delivery agents and to generate an epithermal neutron beam with definite characteristics. Pharmacological companies and research laboratories should have access to accelerators for large‐scale screening of new, more specific boron delivery agents.

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Fe3O4 Nanoparticles for Complex Targeted Delivery and Boron Neutron Capture Therapy

Cited by 147 publications

References 80 publications

Peculiarities of the Crystal Structure Evolution of BiFeO3–BaTiO3 Ceramics across Structural Phase Transitions

Peculiarities of the Crystal Structure Evolution of BiFeO3–BaTiO3 Ceramics across Structural Phase Transitions

Investigation of AC-Measurements of Epoxy/Ferrite Composites

Boron neutron capture therapy: Current status and future perspectives

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